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anti-Human Cathepsin B Antikörper:
anti-Mouse (Murine) Cathepsin B Antikörper:
anti-Rat (Rattus) Cathepsin B Antikörper:
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Human Polyclonal Cathepsin B Primary Antibody für FACS, IHC - ABIN222979
Rybicka, Balce, Chaudhuri, Allan, Yates: Phagosomal proteolysis in dendritic cells is modulated by NADPH oxidase in a pH-independent manner. in The EMBO journal 2012
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Human Polyclonal Cathepsin B Primary Antibody für WB - ABIN3042773
Zhang, Mai, Yang, Dong, Zheng, Yang: CTSB promotes porcine preadipocytes differentiation by degrading fibronectin and attenuating the Wnt/β-catenin signaling pathway. in Molecular and cellular biochemistry 2014
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Human Polyclonal Cathepsin B Primary Antibody für ICC, IF - ABIN4288227
Wang, Chen, Fernandez-Del Castillo, Yilmaz, Deshpande: Heterogeneity in signaling pathways of gastroenteropancreatic neuroendocrine tumors: a critical look at notch signaling pathway. in Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2013
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Human Polyclonal Cathepsin B Primary Antibody für IF (p), IHC (p) - ABIN687412
Liu, Tang, Zhang, Li, Yuan, Wang: Autophagy activation aggravates neuronal injury in the hippocampus of vascular dementia rats. in Neural regeneration research 2014
Human Polyclonal Cathepsin B Primary Antibody für IHC (p), IP - ABIN1996943
Gogiel, Wola?ska, Galewska, Kinalski, Sobolewski, Romanowicz: Cathepsin B in human myometrium and in uterine leiomyomas at various stages of tumour growth. in European journal of obstetrics, gynecology, and reproductive biology 2015
Human Polyclonal Cathepsin B Primary Antibody für ID, WB - ABIN2477930
Martin, Moffitt, McDowell, Greenan, Bright-Thomas, Jones, Webb, Elborn: Association of airway cathepsin B and S with inflammation in cystic fibrosis. in Pediatric pulmonology 2010
Cathepsin B is involved in the programmed cell death of the fat body during B. mori metamorphosis, and that cathepsin B and cathepsin B contribute to B (zeige TDO2 Antikörper). mori metamorphosis.
in CTSB knockout (KO) mice, running did not enhance adult hippocampal neurogenesis and spatial memory function. Interestingly, in Rhesus monkeys and humans, treadmill exercise elevated CTSB in plasma.
Increasing cystatin C (zeige CST3 Antikörper) and cathepsin B reported in serum of colorectal cancer patients.
Interruption of either CCL2 (zeige CCL2 Antikörper)-CCR2 (zeige CCR2 Antikörper) signaling or cathepsin B function significantly impaired perineural invasion (PNI (zeige SERPINE2 Antikörper)).
Expression of CSTA (zeige CSTA Antikörper) was detected in some tumor tissues and many tumor-infiltrating immune cells. Cathepsin B expression was also observed in most tumor tissues and tumor-infiltrating immune cells
Data suggest that expression of CTSB in human glioblastoma cell line can be modulated by dietary factors; here, caffeine decreases tumor size and CTSB expression in mouse xenograft model of glioblastoma; note that caffeine, normally a dietary component, was administered via intraperitoneal injection in these studies.
These results indicate that CST1 (zeige CST1 Antikörper)-mediated extracellular CatB activity enhances tumor development by preventing cellular senescence.
SNPs in NLRP3 (zeige NLRP3 Antikörper) and CTSB, associated with an increased NLRP3 (zeige NLRP3 Antikörper)-inflammasome activation, are protective against the development of active pulmonary tuberculosis.
cathepsin B activity assays identified secreted cathepsin B as responsible for apoA-I (zeige APOA1 Antikörper) cleavage at Ser (zeige SIGLEC1 Antikörper)(228) Importantly
ctsB enhanced neutrophil migration though a putative effect on pseudopod retraction rates.
We have shown that keratolytic winter erythema in South African and Norwegian families is caused by two different tandem duplications in a non-coding genomic region upstream of CTSB.
CtsB/L as major regulators of lysosomal function and demonstrate that CtsB/L may play an important role in intracellular cholesterol trafficking and in degradation of the key AD proteins
Using quenched activity-based probes, we identified mouse cathepsin B (CtsB), which is expressed in the lower regions of the hair follicle, as an additional target of mouse Cst6 (zeige CST6 Antikörper)
After phagocytosis, particles can disrupt lysosomes, and inhibitor studies have suggested that the resulting release of a lysosomal protease-cathepsin B-into the cytosol somehow activates NLRP3 (zeige NLRP3 Antikörper).
the roles of CTSB/S and SIRT1 (zeige SIRT1 Antikörper) in the regulation of hepatic inflammation using primary parenchymal and non-parenchymal hepatic cell types and cell lines.
Mice and macrophages lacking cathepsin B activity had increased resistance to the cytosolic bacterial pathogen Francisella novicida Genetic deletion.
Exposure of J774A.1 cells to HOCl or HOSCN resulted in a significant decrease in the activity of the Cys (zeige DNAJC5 Antikörper)-dependent cathepsins B and L, but not the Asp (zeige C3 Antikörper)-dependent cathepsin D (zeige CTSD Antikörper).
cathepsin B (CTSB) inhibition or expression of a CTSB-resistant Dab2 (zeige DAB2 Antikörper) mutant maintains Dab2 (zeige DAB2 Antikörper) expression and shifts long-term TGF-beta (zeige TGFB1 Antikörper)-treated cells from autophagy to apoptosis
study brings forth a yet unappreciated role for Cathepsin B in regulating T cell responses during Leishmania major infection
Our results suggest that the Mucopolysaccharidosis type I mice have progressive heart failure and valve disease, which may be caused by cathepsin B overexpression.
The cathepsin B deserves further evaluation as therapeutic targets to develop disease modifying drugs to treat Alzheimer's disease.
evidence shows cathepsin B activity may not be redox regulated; however, the stability of the enzyme at neutral pH is dependent on redox potential, and on the presence of oxidising agents.
Overexpressing cathepsin B reduced the Vascular Endothelial Growth Factor-dependent tube response
The peptides, all of which contain a C-terminal free acid, were tested as inactivators of bovine cathepsin B, in an attempt at exploiting the known and, amongst the cysteine proteinases, unique carboxy dipeptidyl peptidase (zeige ACE Antikörper) activity of the protease.
Findings showed that CTSB facilitates adipogenesis, and its effect is associated with fibronectin degradation and Wnt/b-catenin signaling pathway.
CTSB may be required to remodel endometrial and placental tissues for close apposition between maternal and fetal vasculatures and to facilitate transplacental transport of gases, micronutrients (amino acids, glucose), and macromolecules (proteins).
The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the encoded protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene.
, cathepsin B-2744
, cathepsin B-1674
, cathepsin B-84
, cathepsin B-3098
, cathepsin B-16D2
, cathepsin B-1874
, cathepsin B-3483
, cathepsin B-10270
, APP secretase
, amyloid precursor protein secretase
, cathepsin B1
, cysteine protease