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The abnormal phenotype of the cnx1 crt1 crt2 crt3 quadruple mutants was completely rescued by either the CNX1 or CNX2 cDNA under the control of the CNX1 promoter, suggesting functional redundancy between CNX1 and CNX2. Taken together, these results provide genetic evidence that CNX (zeige CANX ELISA Kits) and CRT (zeige CALR ELISA Kits) play essential and overlapping roles during vegetative growth and male gametophyte development in Arabidopsis
A triple knockout mutant, t123, which lacks CRT1, CRT2 and CRT3 was generated to examine the roles of calreticulins in abiotic stress tolerance.
Arabidopsis CRT2 is a pathogen-responsive gene with a potential role in disease resistance. Over-expression of CRT2 results in pleiotropic phenotypes with increased salicylic acid levels.
POD1 (zeige TCF21 ELISA Kits) is a novel ER luminal protein involved in ER protein retention and interacts with CALRETICULIN3.
ADAM2, CALR3 and SAGE1 cancer/testis antigens are not promising targets for immunotherapy of breast and lung cancer.
Calreticulin-2 is localized in the lumen of the endoplasmic reticulum but is not a Ca2 (zeige CA2 ELISA Kits)+ -binding protein.
CRT2 is a novel cancer-testis antigen frequently expressed in various cancers
Calsperin is a testis-specific (zeige AIF1 ELISA Kits) chaperone required for sperm fertility.
The protein encoded by this gene belongs to the calreticulin family, members of which are calcium-binding chaperones localized mainly in the endoplasmic reticulum. This protein is also localized to the endoplasmic reticulum lumen, however, its capacity for calcium-binding may be absent or much lower than other family members. This gene is specifically expressed in the testis, and may be required for sperm fertility. Mutation in this gene has been associated with familial hypertrophic cardiomyopathy.
, calreticulin 3
, cancer/testis antigen 93