TNFSF9 Proteine (TNFSF9)

Bezeichnung:
Tumor Necrosis Factor (Ligand) Superfamily, Member 9 Proteine (TNFSF9)
Auf www.antikoerper-online.de finden Sie aktuell 47 Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9) Proteine von 15 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen TNFSF9 Antikörper (226) und TNFSF9 Kits (8) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 290 TNFSF9 Produkte verfügbar.
Synonyme:
4-1BB-L, 4-1BBL, AI848817, CD137L, Ly63l, TNFSF9
alle Proteine anzeigen Gen GeneID UniProt
TNFSF9 353218  
TNFSF9 21950 P41274
TNFSF9 8744 P41273

Weitere Synonyme anzeigen

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Am meisten referenzierte TNFSF9 Proteine

  1. Human TNFSF9 Protein expressed in HEK-293 - ABIN2666577 : Locatelli: Tolerance: pregnancy matters. in Blood 2009 (PubMed)
    Zeige alle 7 Referenzen für 2666577

  2. Human TNFSF9 Protein expressed in Escherichia coli (E. coli) - ABIN1046588 : Alderson, Smith, Tough, Davis-Smith, Armitage, Falk, Roux, Baker, Sutherland, Din: Molecular and biological characterization of human 4-1BB and its ligand. in European journal of immunology 1994 (PubMed)
    Zeige alle 2 Referenzen für 1046588

  3. Mouse (Murine) TNFSF9 Protein expressed in Human Cells - ABIN2007262 : Goodwin, Din, Davis-Smith, Anderson, Gimpel, Sato, Maliszewski, Brannan, Copeland, Jenkins: Molecular cloning of a ligand for the inducible T cell gene 4-1BB: a member of an emerging family of cytokines with homology to tumor necrosis factor. in European journal of immunology 1993 (PubMed)
    Zeige alle 2 Referenzen für 2007262

  4. Human TNFSF9 Protein expressed in Escherichia coli (E. coli) - ABIN667100 : Lee, Park, So, Kwon, Cheroutre, Mittler, Croft: Identification of regulatory functions for 4-1BB and 4-1BBL in myelopoiesis and the development of dendritic cells. in Nature immunology 2008 (PubMed)
    Zeige alle 2 Referenzen für 667100

Weitere Proteine zu TNFSF9 Interaktionspartnern

Mouse (Murine) Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9) Interaktionspartner

  1. Constitutive interaction between 4-1BB (zeige TNFRSF9 Proteine) and 4-1BBL on murine LPS (zeige TLR4 Proteine)-activated bone marrow dendritic cells masks detection of 4-1BBL by TKS (zeige PTK6 Proteine)-1 but not 19H3 antibody.

  2. 4-1BBL can restrain effector T cell development, creating a more favorable regulatory T cell to effector cell balance under tolerogenic conditions, and this may be particularly active in mucosal barrier tissues

  3. These results demonstrate that 4-1BBL-engineered DCs can improve CIKs (zeige TRAF3IP2 Proteine) cytotoxicity against prostate cancer cells.

  4. these observations suggest that inhibition of the TLR/4 (zeige TLR4 Proteine)-1BBL complex formation may be highly efficient in protecting against continued inflammation

  5. 4-1BB (zeige TNFRSF9 Proteine) mediates the inflammatory responses in obese skeletal muscle by interacting with its ligand 4-1BBL on macrophages.

  6. CD137 (zeige TNFRSF9 Proteine)-CD137L interactions mediated via regulation of CyPA (zeige PPIA Proteine) contribute to the progression of atherosclerosis.

  7. Data indicate that CD137L deficient mice displayed a variety of immunological dysfunctions.

  8. monocytes interact with iNKT cells to increase expression of 4-1BBL and 4-1BB (zeige TNFRSF9 Proteine), and in conjunction with this pathway, maintain their numbers at baseline.

  9. CD137 (zeige TNFRSF9 Proteine)-expressing CD4 (zeige CD4 Proteine)+ T cells in the bone marrow engage CD137L on hematopoietic progenitor cells, and this CD137L signaling biases hematopoiesis towards myelopoiesis during aging.

  10. TIRAP (zeige TIRAP Proteine) and IRAK2 (zeige IRAK2 Proteine) are critical for the sustained inflammatory response that is mediated by late-phase signaling by the TLR-4 (zeige TLR4 Proteine)-1BBL complex.

Human Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9) Interaktionspartner

  1. blocking of both OX-40L (zeige TNFSF4 Proteine) and 4-1BBL reversed radiation-enhanced T-cell killing of human tumor targets as well as T-cell survival and activation.

  2. CD137L is overexpressed in non-small cell lung cancer specimens and positive expression of CD137L was associated with better overall survival.

  3. In vitro immunotherapy is described for anti-prostate cancer effects of cytotoxic T lymphocytes induction by recombinant adenovirus mediated PSMA/4 (zeige PSMA4 Proteine)-1BBL dendritic cells.

  4. vaccination with recombinant attenuated Salmonella harboring the CEACAM6 and 4-1BBL gene efficiently increased the number of CD3 (zeige CD3 Proteine)+CD8 (zeige CD8A Proteine)+ TIL (zeige TLR1 Proteine) and NK cells, decreased the number of FOXP3 (zeige FOXP3 Proteine) cells and inhibited the development of DMH (zeige DST Proteine)-induced colorectal cancer

  5. Elevated plasma levels and monocyte-associated expression of CD137 (zeige TNFRSF9 Proteine) ligand in patients with acute atherothrombotic stroke

  6. Hence, the targeted combination of IL-15 (zeige IL15 Proteine) and 4-BBL (zeige TP53 Proteine) in the form of a trifunctional antibody-fusion protein is a promising new approach for cancer immunotherapy.

  7. monocytes interact with iNKT cells to increase expression of 4-1BBL and 4-1BB (zeige TNFRSF9 Proteine), and in conjunction with this pathway, maintain their numbers at baseline.

  8. TIRAP (zeige TIRAP Proteine) and IRAK2 (zeige IRAK2 Proteine) are critical for the sustained inflammatory response that is mediated by late-phase signaling by the TLR-4 (zeige TLR4 Proteine)-1BBL complex.

  9. this is the first study to indicate that this member of the TNF (zeige TNF Proteine) superfamily, CD137 (zeige TNFRSF9 Proteine), is modulated by SAHA treatment in breast

  10. Data show that TNFR1 (zeige TNFRSF1A Proteine) associates with CD137L and is required for CD137L reverse signaling.

TNFSF9 Protein Überblick

Protein Überblick

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.

Alternative names and synonyms associated with TNFSF9

  • tumor necrosis factor (ligand) superfamily, member 9 (Tnfsf9)
  • tumor necrosis factor (ligand) superfamily, member 9 (TNFSF9)
  • 4-1BB-L Protein
  • 4-1BBL Protein
  • AI848817 Protein
  • CD137L Protein
  • Ly63l Protein
  • TNFSF9 Protein

Bezeichner auf Proteinebene für TNFSF9

costimulatory molecule , tumor necrosis factor (ligand) superfamily, member 9 , 4-1BB ligand , tumor necrosis factor ligand superfamily member 9 , 4-1BBL , homolog of mouse 4-1BB-L , receptor 4-1BB ligand

GENE ID SPEZIES
353218 Rattus norvegicus
476729 Canis lupus familiaris
521748 Bos taurus
21950 Mus musculus
8744 Homo sapiens
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