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The objective of this study was to characterize the profiles of Ang-(1-7), MAS receptor, ACE(2), NEP and PEP during the ovulatory process in cattle.
Here, we review the role and effects of ACE2 (zeige ACE2 Proteine), ACE2 (zeige ACE2 Proteine) activators, Ang-(1 (zeige ANGPT1 Proteine)-7) and synthetic Mas receptor agonists in the control of inflammation and fibrosis in cardiovascular and renal diseases and as counter-regulators of the ACE (zeige ACE Proteine)-Ang II (zeige AGT Proteine)-AT1 (zeige AGTR1 Proteine) axis.
Downregulation of ACE2 (zeige ACE2 Proteine)/Ang-(1 (zeige ANGPT1 Proteine)-7)/Mas axis stimulates breast cancer metastasis through the activation of store-operated calcium entry and PAK1 (zeige PAK1 Proteine)/NF-kappaB (zeige NFKB1 Proteine)/Snail1 (zeige SNAI1 Proteine) pathways.
These results indicated that angiotensin-(1-7)/ACE2 (zeige ACE2 Proteine)/Mas axis may reduce liver lipid accumulation partly by regulating lipid-metabolizing genes through ATP/P2 receptor/CaM (zeige CALM1 Proteine) signaling pathway.
Ang-(1 (zeige ANGPT1 Proteine)-7) downregulated AT1R (zeige AGTR1 Proteine) mRNA, upregulated mRNA levels of Ang II (zeige AGT Proteine) type 2 receptor (AT2R (zeige AGTR2 Proteine)) and Mas receptor (MasR) and p38-MAPK (zeige MAPK14 Proteine) phosphorylation and suppressed H22 cell-endothelial cell communication
MAS1 might act as an inhibitory regulator of breast cancer.
Data show that MAS receptor exhibited constitutive activity that was inhibited by the non-peptide inverse agonist.
Data suggest that angiotensin converting enzyme 2 (zeige ACE2 Proteine)/angiotensin II-(1-7)/MAS1 axis regulates leukocyte recruitment/activation, cell proliferation, and inflammation/fibrosis; main topic here is kidney/inflammatory renal disease. [REVIEW]
Up-regulation of the ACE2 (zeige ACE2 Proteine)/Ang-(1 (zeige ANGPT1 Proteine)-7)/Mas axis protected against pulmonary fibrosis by inhibiting the MAPK (zeige MAPK1 Proteine)/NF-kappaB (zeige NFKB1 Proteine) pathway.
A proximal promoter construct for the MAS gene was repressed by the SOX (zeige PIPOX Proteine) [SRY (zeige SRY Proteine) (sex-determining region on the Y chromosome) box] proteins SRY (zeige SRY Proteine), SOX2 (zeige SOX2 Proteine), SOX3 (zeige SOX3 Proteine) and SOX14 (zeige SOX14 Proteine), of which SRY (zeige SRY Proteine) is known to interact with the KRAB domain.
Mas appears to be a critical component required for NO-mediated vasodilatation induced by renin angiotensin system-dependent and RAS-independent agonists and therefore arises as a key pharmacological target to modulate endothelial function
MasR deficiency abolishes protection of female mice from obesity-induced hypertension
Results suggest that angiotensin converting enzyme 2 (zeige ACE2 Proteine) may reduce anxiety-like behavior by activating central Mas receptor that facilitate GABA release onto pyramidal neurons within the basolateral amygdala.
impairment of the ANG-(1 (zeige ANGPT1 Proteine)-7)/Mas receptor pathway may lead to worsening of the pathophysiological changes of asthma.
The data indicate a significant function of Ang-(1 (zeige ANGPT1 Proteine)-7) in the regulation of insulin (zeige INS Proteine) secretion from mouse islets in vitro and in vivo, mainly, but not exclusively, by Mas-dependent signaling, modulating the accessory pathway of insulin (zeige INS Proteine) secretion via increase in cAMP.
This study suggests that deletion of AT2R decreases the expression of the beneficial ACE2/Ang-(1-7)/MasR.
Ang-(1 (zeige ANGPT1 Proteine)-7)/Mas axis seems more important in autonomic modulation of arterial pressure than heart rate.
Mas receptor mediates cardioprotection of angiotensin-(1-7) against Ang II (zeige AGT Proteine)-induced cardiomyocyte autophagy and cardiac remodelling through inhibition of oxidative stress.
MAS receptors mediate vasoprotective and atheroprotective effects of candesartan upon the recovery of vascular ACE2 (zeige ACE2 Proteine)-angiotensin-(1-7)-MAS axis functionality
Mas receptor deficiency results in exacerbated inflammation in LPS (zeige TLR4 Proteine)-challenged mice, which suggest a potential role for the Mas receptor as a regulator of systemic and brain inflammatory response induced by LPS (zeige TLR4 Proteine).
a Mas receptor-mediated mechanism may stimulate pancreatic cell development
oncogene\; may be involved in function or development of neural tissues
, proto-oncogene Mas
, MAS proto-oncogene
, angiotensin-(1-7) receptor