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STK3 encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Zusätzlich bieten wir Ihnen STK3 Antikörper (90) und STK3 Proteine (16) und viele weitere Produktgruppen zu diesem Protein an.
Results show that STK3 is targeted by Casp6 (zeige CASP6 ELISA Kits) and demonstrate that alterations in STK3 protein expression levels and post-translational modifications are detected in a cellular model of HD and caspase (zeige CASP3 ELISA Kits)-mediated generation of STK3 fragments observed under conditions of stress in cells expressing mhtt.
using an Mst2 mutation that disrupts homotypic dimerization, we showed that the monomeric Mst2-SARAH domain could form a stable complex of 1:1 stoichiometric ratio with WW45 (zeige SAV1 ELISA Kits) refolded under acidic pH.
The MST1/2-SAV1 complex, a core component of the Hippo pathway, promotes ciliogenesis.
These results suggest that AIF (zeige AIFM1 ELISA Kits) downregulation is a common event in kidney tumor development. AIF (zeige AIFM1 ELISA Kits) loss may lead to decreased STK3 activity, defective apoptosis and malignant transformation
Hippo and Yap (zeige YAP1 ELISA Kits) regulate cardiomyocyte death and regeneration.
results reveal a novel role of Mst2 in stress-dependent cardiac hypertrophy and remodeling in the adult mouse and likely human heart
Results indicate that changes in phosphorylation orchestrate interactions between kinases and phosphatases in Hippo (MST1 (zeige MST1 ELISA Kits)/2 protein kinases) signaling, providing a putative mechanism for pathway regulation.
RASSF5 (zeige RASSF5 ELISA Kits) can act as an inhibitor or a potential positive regulator of Mst2, depending on whether it binds to Mst2 before or after activation-loop phosphorylation.
results of the present study revealed that, in addition to the phosphorylated YAP (zeige YAP1 ELISA Kits)/TAZ (zeige TAZ ELISA Kits), the Hippo pathway can suppress the Wnt (zeige WNT2 ELISA Kits)/beta-catenin (zeige CTNNB1 ELISA Kits) pathway directly through MST1 (zeige MST1 ELISA Kits)/2
The ability of K-Ras to activate MST2 and MST2-dependent apoptosis is determined by the differential activation kinetics of mutant K-Ras and wild type K-Ras.
Studies indicate that Hippo (Hpo (zeige GFER ELISA Kits); MST1 (zeige MST1 ELISA Kits)/2 in mammals) signaling pathway plays a central role in the cell fate-specification process.
Mst2 is involved in bone homeostasis, functioning as a reciprocal regulator of osteoclast and osteoblast differentiation through the NF-kappaB (zeige NFKB1 ELISA Kits) pathway
the TLR-Mst1 (zeige MST1 ELISA Kits)-Mst2-Rac (zeige AKT1 ELISA Kits) signaling axis is critical for effective phagosome-mitochondrion function and bactericidal activity
These data indicate that that inhibition of mammalian sterile 20-like kinase 1 (zeige STK4 ELISA Kits) rescued cardiac fibrosis and myocardial dysfunction in chronic beta1-adrenergic receptor stimulation-induced cardiomyopathy
Phosphorylation of LC3 (zeige MAP1LC3A ELISA Kits) by the STK3 (zeige PKN1 ELISA Kits) and STK4 is essential for autophagy.
These results identify MST2, not MST1 (zeige MST1 ELISA Kits), as a critical regulator of caspase (zeige CASP3 ELISA Kits)-mediated photoreceptor cell death in the detached retina and indicate its potential as a future neuroprotection target.
Mst1 (zeige MST1 ELISA Kits)/2 regulate placental development by control of trophoblast cell differentiation and labyrinthine vasculature at midgestation and Mst1 (zeige MST1 ELISA Kits)/2 control labyrinth morphogenesis in trophoblast- and fetal endothelial-dependent manners.
results showed that Mst1 (zeige MST1 ELISA Kits)/Mst2 are required for proper cardiac lineage cell development and teratoma (zeige DND1 ELISA Kits) formation.
these findings indicate that Mst1 (zeige MST1 ELISA Kits)/2 are important for controlling Treg development and preventing autoimmunity in mice, but also shed new light on our understanding of Mst1 (zeige MST1 ELISA Kits) deficiency-mediated human immunodeficiency syndrome.
This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.
, STE20-like kinase MST2
, mammalian STE20-like protein kinase 2
, serine/threonine kinase 3 (STE20 homolog, yeast)
, serine/threonine kinase 3 (Ste20, yeast homolog)
, serine/threonine-protein kinase 3
, serine/threonine-protein kinase Krs-1
, protein kinase homolog
, serine/threonine kinase 3 (STE20 homolog)