anti-serine/arginine-Rich Splicing Factor 2 (SRSF2) Antikörper

The protein encoded by SRSF2 is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Zusätzlich bieten wir Ihnen SRSF2 Kits (15) und SRSF2 Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
SRSF2 6427 Q01130
SRSF2 20382 Q62093
SRSF2 494445 Q6PDU1
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Top anti-SRSF2 Antikörper auf antikoerper-online.de

Showing 10 out of 34 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-SFRS2 AntibodyTitration: 1.0 µg/mL <br /> Positive Control: Hela Whole Cell <br /> SRSF2 is strongly supported by BioGPS gene expression data to be expressed in Human HeLa cells 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Kaninchen Unkonjugiert WB Western blot analysis of SFRS2 Antibody (Center) (ABIN650729) in mouse stomach tissue lysates (35 µg/lane). SFRS2 (arrow) was detected using the purified polyclonal antibody. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert IHC (p), WB Western blot analysis of anti-SFRS2 Antibody (N-term) (ABIN389301) in K562 cell line lysates (35 µg/lane).SFRS2(arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with SFRS2 antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert EIA, WB Western blot analysis of SFRS2 Antibody (Center) in mouse stomach tissue lysates (35ug/lane). SFRS2 (arrow) was detected using the purified Pab. 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Kaninchen Unkonjugiert ELISA, WB 0.1 mg Anmelden zum Anzeigen 2 bis 6 Tage
$275.00
Details
Amphibien Maus Unkonjugiert ELISA, EM, ICC, IF, IP, WB Immunocytochemistry/Immunofluorescence: SC35 Antibody (SC-35) [ABIN151301] - HS-68 cells were fixed and permeabilized with 4% Paraformaldehyde and 0.5% Triton X-100. Fixed cells were stained with Mouse Anti-Splicing Factor Clone: SC-35 diluted to 1:2,000. The antibody was developed using Goat Anti-Mouse IgG, FITC-conjugate. Western Blot: SC35 Antibody (SC-35) [ABIN151301] - SC-35 recombinant protein (3 ug) was separated on SDS-PAGE and probed with Mouse Anti-Splicing Factor SC-35 Clone: SC-35. The antibody was developed using Goat Anti-Mouse IgG-Peroxidase and a chemiluminescent substrate. Lanes 1. Antibody dilution 1:100; 2. Antibody dilution 1:250; 3. Antibody dilution 1:500; 4. Antibody dilution 1:1,000 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$381.94
Details
Human Maus Unkonjugiert IF, IP, WB Western blot analysis of SC35. Lysates from MG-63 human osteosarcoma cells were probed with anti-SC35 (clone alphaSC35, ABIN967516). SC35 is detected as a band of ~35 kDa. 0.1 mg Anmelden zum Anzeigen 6 bis 8 Tage
$177.30
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p) Immunohistochemistry: SC35 Antibody [NBP2-47290] - Analysis of human Analysis of human skin tissue. Shows nuclear positivity. Immunocytochemistry/Immunofluorescence: SC35 Antibody [NBP2-47290] - Analysis of human cell line HEK 293 shows positivity in nucleus & cytoplasm. 0.1 mL Anmelden zum Anzeigen 14 bis 17 Tage
$439.69
Details
Huhn Kaninchen Unkonjugiert IHC (p), WB Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$676.50
Details

SRSF2 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität
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Mouse (Murine) ,


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Am meisten referenzierte anti-SRSF2 Antikörper

  1. Amphibian Monoclonal SRSF2 Primary Antibody für ELISA, EM - ABIN151301 : Nie, Hampton, Fu, Liu, Findlay, Salamonsen: A potential molecular mechanism for regulating pre-mRNA splicing of implantation-related genes through unique uterine expression of splicing factor SC35 in women and rhesus monkeys. in Reproduction (Cambridge, England) 2002 (PubMed)
    Show all 7 Pubmed References

  2. Human Monoclonal SRSF2 Primary Antibody für IF, IP - ABIN967516 : Fu: Specific commitment of different pre-mRNAs to splicing by single SR proteins. in Nature 1993 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal SRSF2 Primary Antibody für ICC, IF - ABIN4352137 : Guantes, Rastrojo, Neves, Lima, Aguado, Iborra: Global variability in gene expression and alternative splicing is modulated by mitochondrial content. in Genome research 2015 (PubMed)

Weitere Antikörper gegen SRSF2 Interaktionspartner

Human serine/arginine-Rich Splicing Factor 2 (SRSF2) Interaktionspartner

  1. The aberrantly spliced target genes and deregulated cellular pathways associated with the commonly mutated splicing factor (zeige SLU7 Antikörper) genes in myelodysplastic syndromes (SF3B1 (zeige SF3B2 Antikörper), SRSF2 and U2AF1 (zeige U2AF1 Antikörper)) are being identified, illuminating the molecular mechanisms underlying the disease. (Review)

  2. adverse prognostic impact of SRSF2 mutations on OS and AML (zeige RUNX1 Antikörper) transformation in patients with de novo MDS (zeige PAFAH1B1 Antikörper)

  3. SRSF2 mutation is associated with chronic myelomonocytic leukemia.

  4. Mutation in SRSF2 gene is associated with Uveal Melanoma.

  5. Myelodysplastic syndrome -related P95 (zeige NBN Antikörper) point mutants of SRSF2 lead to alternative splicing of CDC25C (zeige CDC25C Antikörper) in a manner that is not dependent on the DNA damage response.

  6. Findings identify SRSF2 as a key regulator of RNA splicing dysregulation in cancer, with possible clinical implications as a candidate prognostic factor in patients with HCC (zeige FAM126A Antikörper).

  7. depletion of the splicing factor (zeige SLU7 Antikörper) arginine-rich splicing factor 2 (zeige SRSF1 Antikörper) (SRSF2) leads to enhanced cytotoxicity of breast cancer cells by KM100

  8. Data suggest that RBM25 (zeige RBM25 Antikörper) is required for the viability of multiple human cell lines, suggesting that it could play a key role in pre-mRNA splicing; a region of RBM25 (zeige RBM25 Antikörper) spanning Lys77 binds with high affinity to SRSF2, a crucial protein in exon definition, but only when Lys77 is unmethylated. (RBM25 (zeige RBM25 Antikörper) = RNA binding motif protein 25 (zeige RBM25 Antikörper); SRSF2 = serine- and arginine-rich splicing factor 2 (zeige SRSF1 Antikörper))

  9. mutations in the SRSF2/ASXL1 (zeige ASXL1 Antikörper)/RUNX1 (zeige RUNX1 Antikörper) gene panel identified as significant prognostic markers in systemic mastocytosis

  10. It was found that the absence of mutations in the SRSF2, ASXL1 (zeige ASXL1 Antikörper), and/or RUNX1gene panel at baseline and a reduction of the KIT D816V allele burden more than 25% at month 6 are the most favorable predictors for improved survival in midostaurin-treated advanced systemic mastocytosis patients.

Mouse (Murine) serine/arginine-Rich Splicing Factor 2 (SRSF2) Interaktionspartner

  1. Mice expressing Srsf2 mutation Srsf2P95H, which commonly occurs in individuals with MDS (zeige MECOM Antikörper) and AML (zeige RUNX1 Antikörper), in an inducible, hemizygous manner in hematopoietic cells rapidly succumbed to fatal bone marrow failure, demonstrating that Srsf2-mutated cells depend on the wild-type Srsf2 allele for survival.

  2. Findings have shown that SRSF2 not only is involved in splicing regulation of a large number of transcripts but also activates transcription of metabolism-related genes and transcription factors.

  3. Depletion of SRSF2 enhances reovirus replication and cytopathic effect, suggesting that T1L (zeige CERS6 Antikörper) mu2 (zeige AP2M1 Antikörper) modulation of splicing benefits the virus.

  4. HIV-1-Tat (zeige TAT Antikörper) Protein Inhibits SC35-mediated Tau Exon 10 Inclusion through Up-regulation of DYRK1A (zeige DYRK1A Antikörper) Kinase.

  5. The findings suggest that intact SRSF2 is essential for the functional integrity of the hematopoietic system and that its mutations likely contribute to development of myelodysplastic syndromes.

  6. SRSF2 mutations alter SRSF2's normal sequence-specific RNA binding activity, thereby altering the recognition of specific exonic splicing enhancer motifs to drive recurrent mis (zeige AMH Antikörper)-splicing of key hematopoietic regulators

  7. Study reports that SRSF2 (also known as SC35, an SR-splicing factor (zeige SLU7 Antikörper)) is part of the 7SK complex assembled at gene promoters and plays a direct role in transcription pause release.

  8. Specific effects on regulated splicing by SR proteins SRSF1 (zeige SRSF1 Antikörper) and SRSF2 depends on a complex set of relationships with multiple other SR proteins in mammalian genomes.

  9. Deficiency of the splicing factor (zeige SLU7 Antikörper) Sfrs10 results in early embryonic lethality in mice and has no impact on full-length SMN/Smn (zeige STMN1 Antikörper) splicing.

  10. Oct-4 distribution was examined relative to that of the unphosphorylated form of RNA polymerase II (Pol II) and splicing factor (SC 35) in the intranuclear entities such as perichromatin fibrils.

SRSF2 Antigen-Profil

Protein Überblick

The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding the same protein and one non-coding transcript variant have been found for this gene. In addition, a pseudogene of this gene has been found on chromosome 11.

Genbezeichner und Symbole assoziert mit SRSF2

  • serine and arginine rich splicing factor 2 (SRSF2) Antikörper
  • serine/arginine-rich splicing factor 2 (Srsf2) Antikörper
  • serine and arginine rich splicing factor 2 (Srsf2) Antikörper
  • serine/arginine-rich splicing factor 2 L homeolog (srsf2.L) Antikörper
  • D11Wsu175e Antikörper
  • MRF-1 Antikörper
  • pr264 Antikörper
  • sc-35 Antikörper
  • sc35 Antikörper
  • sfrs2 Antikörper
  • sfrs2a Antikörper
  • Sfrs10 Antikörper
  • srp30b Antikörper

Bezeichner auf Proteinebene für SRSF2

SR splicing factor 2 , splicing component, 35 kDa , splicing factor SC35 , splicing factor, arginine/serine-rich 2 , myelin regulatory factor 1 , putative myelin regulatory factor 1 , splicing factor Sc35 , splicing factor, arginine/serine-rich 2 (SC-35) , SC-35 , PR 264 protein , arginine/serine-rich2 splicing factor

GENE ID SPEZIES
6427 Homo sapiens
20382 Mus musculus
494445 Rattus norvegicus
508312 Bos taurus
396195 Gallus gallus
768117 Sus scrofa
380435 Xenopus laevis
Ausgewählte Anbieter für anti-SRSF2 (SRSF2) Antikörper
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