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SPINT2 encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. Zusätzlich bieten wir Ihnen SPINT2 Antikörper (100) und SPINT2 Kits (8) und viele weitere Produktgruppen zu diesem Protein an.
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Our data indicate that hypoxic inhibition of JMJD3 activity reduces demethylation of H3K27me3, nucleosome removal, and hence induction of the STAT6 target gene CCL18, while induction of other STAT6-inducible genes such as SPINT2 remained unaffected by JMJD3.
Concomitant presence of TMPRSS13 (zeige TMPRSS13 Proteine) with HAI-2 mediates phosphorylation of residues in the intracellular domain of the protease, and it coincides with efficient transport of the protease to the cell surface and its subsequent shedding.
This study presented a molecular characterization of congenital tufting enteropathy Italian patients, and identified one mutation in the SPINT2 gene
study the methylation status of the promoter region of Serine peptidase inhibitor/hepatocyte growth factor activator inhibitor type 2 (SPINT2/HAI-2)
It suggests an involvement of SPINT2 in PCa (zeige FLVCR1 Proteine) tumorigenesis, probably in association with a post-translational regulation of SPINT2.
N-glycan branching regulates HAI-2 through different subcellular distribution and subsequently access to different target proteases
Matriptase (zeige ST14 Proteine) inhibition by HAI-2 requires the translocation of HAI-2 to the cell surface, a process which is observed in some breast cancer cells but not in mammary epithelial cells.
Epigenetic silencing of SPINT2 promotes cancer cell motility in malignant melanoma.
a missense mutation in the serine protease inhibitor SPINT2 may have a role in congenital sodium diarrhea
results suggest that the SPINT2 underexpression in the MSC (zeige MSC Proteine) from MDS (zeige PAFAH1B1 Proteine) patients is probably involved in the adhesion of progenitors to the bone marrow niche, through an increased HGF (zeige HGF Proteine) and SDF-1 (zeige CXCL12 Proteine) signaling pathway.
HAI-1 (zeige SPINT1 Proteine) regulates the activity of activated matriptase (zeige ST14 Proteine), whereas HAI-2 has an essential role in regulating prostasin (zeige PRSS8 Proteine)-dependent matriptase (zeige ST14 Proteine) zymogen activation.
mutations in Prss8 (zeige PRSS8 Proteine) restored placentation and normal development of HAI-1 (zeige SPINT1 Proteine)-deficient embryos and prevented early embryonic lethality, mid-gestation lethality due to placental labyrinth failure, and neural tube defects in HAI-2-deficient embryos.
HAI-1 (zeige SPINT1 Proteine) and -2 are overexpressed in the liver in cholangiopathies with ductular reactions and are possibly involved in liver fibrosis and hepatic differentiation.
Unlike HAI-1 (zeige SPINT1 Proteine) and matriptase (zeige ST14 Proteine), HAI-2 expression is detected in non-epithelial cells of brain and lymph nodes, suggesting that HAI-2 may also be involved in inhibition of serine proteases other than matriptase (zeige ST14 Proteine)
Inhibition of the transmembrane serine protease (zeige F2 Proteine) matriptase (zeige ST14 Proteine) (encoded by St14 (zeige ST14 Proteine)) is an essential function of HAI2 during tissue morphogenesis.
This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene.
hepatocyte growth factor activator inhibitor type 2
, placental bikunin
, serine protease inhibitor, Kunitz type 2
, kunitz-type protease inhibitor 2
, serine protease inhibitor, Kunitz type, 2