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PEA15 encodes a death effector domain-containing protein, which is a major phosphoprotein in astrocytes, and an endogenous substrate for protein kinase C. Zusätzlich bieten wir Ihnen PEA15 Antikörper (111) und PEA15 Proteine (13) und viele weitere Produktgruppen zu diesem Protein an.
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PEA15 expression was not significantly correlated with ovarian cancer antineoplastic drug resistance.
Data suggest the role of the phospholipase C epsilon (zeige PLCL1 ELISA Kits)-Protein kinase D (zeige PRKD1 ELISA Kits)-PEA15 protein-ribosomal S6 kinase (zeige RPS6KB1 ELISA Kits)-IkappaB-NF-kappa B (zeige NFKB1 ELISA Kits) pathway in facilitating inflammation and inflammation-associated carcinogenesis in the colon.
Integrin alpha5beta1 and p53 (zeige TP53 ELISA Kits) convergent pathways in the control of anti-apoptotic proteins PEA-15 and survivin (zeige BIRC5 ELISA Kits) in high-grade glioma.
High PED expression is associated with esophageal carcinoma.
The nuclear translocation of SApErk1/ 2 apart from PEA-15 as an important mechanism to reverse senescence phenotype.
Latent HCMV infection of CD34 (zeige CD34 ELISA Kits) + cells protects cells from FAS (zeige FAS ELISA Kits)-mediated apoptosis through the cellular IL-10 (zeige IL10 ELISA Kits)/PEA-15 pathway.
New therapeutic targets based around PEA-15 and its associated interactions are now being uncovered and could provide novel avenues for treatment strategies in multiple diseases.
PED/PEA-15 overexpression is sufficient to block hydrogen peroxide-induced apoptosis in Ins-1E cells through a PLD-1 mediated mechanism
Omi/HtrA2 (zeige HTRA2 ELISA Kits) overexpression promotes hepatocellular carcinoma cell apoptosis and the ped/pea-15 expression level causes this difference of the Omi/HtrA2 (zeige HTRA2 ELISA Kits) pro-apoptotic marker in the various hepatocellular carcinoma cell lines
Results suggest that neurochemical adaptations of brain FADD (zeige FADD ELISA Kits), as well as its interaction with PEA-15, could play a major role to counteract the known activation of the mitochondrial apoptotic pathway in major depression
Data suggest that PEA-15 contributes to the specification of the cytokine pattern of activated Th cells, thus highlighting a potential new target to interfere with T cell functional polarization and subsequent immune response.
Activated astrocytes are known to clear the Abeta (zeige APP ELISA Kits) deposited in the extracellular milieu, which is why they play a key role in regulating the progression of Alzheimer's disease (AD).
Activation of peroxisome proliferator-activated receptor-gamma (PPARgamma (zeige PPARG ELISA Kits)) represses transcription of the ped/pea-15 gene.
The findings revealed a novel mechanism by which PEA-15 positively regulates Ras/ERK signaling and increases the proliferation of H-Ras-transformed epithelial cells through enhanced phospholipase D1 expression and activation.
PEA-15 did not differentiate and showed markedly enhanced autophagy. In these same cells, the autophagy inhibitor 3 (zeige PPP1R11 ELISA Kits)-methyladenine rescued TGF-beta1 (zeige TGFB1 ELISA Kits) effect on both autophagy and myogenesis, indicating that PEA-15 mediates TGF-beta1 (zeige TGFB1 ELISA Kits) effects in muscle.
Data suggest that PED/PEA-15 may affect fibroblast motility by a mechanism, at least in part, mediated by ERK1/2 (zeige MAPK1/3 ELISA Kits).
we propose that PEA-15 represents a novel point of convergence of the protein kinas C and MAPK/ERK (zeige MAPK1 ELISA Kits) pathways under gonadotropin releasing hormone stimulation
PEA-15 regulates T-cell proliferation
PEA-15 inhibits tumorigenesis in an MDA-MB-468 triple-negative breast cancer xenograft model through increased cytoplasmic localization of activated extracellular signal-regulated kinase.
This gene encodes a death effector domain-containing protein, which is a major phosphoprotein in astrocytes, and an endogenous substrate for protein kinase C. Studies using knockout mice suggest that this protein may protect astrocytes from TNF-induced apoptosis. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake.
phosphoprotein enriched in astrocytes 15
, Astrocytic phosphoprotein PEA-15
, 15 kDa phosphoprotein enriched in astrocytes
, Phosphoprotein enriched in astrocytes, 15kD
, astrocytic phosphoprotein PEA-15
, homolog of mouse MAT-1 oncogene
, phosphoprotein enriched in diabetes
, phosphoprotein enriched in astrocytes 15A
, mammary transforming gene 1