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PEA15 encodes a death effector domain-containing protein, which is a major phosphoprotein in astrocytes, and an endogenous substrate for protein kinase C. Zusätzlich bieten wir Ihnen PEA15 Proteine (11) und PEA15 Kits (7) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal PEA15 Primary Antibody für FACS, IHC (p) - ABIN652463
Trencia, Perfetti, Cassese, Vigliotta, Miele, Oriente, Santopietro, Giacco, Condorelli, Formisano, Beguinot: Protein kinase B/Akt binds and phosphorylates PED/PEA-15, stabilizing its antiapoptotic action. in Molecular and cellular biology 2003
Show all 3 Pubmed References
PP4 (zeige ANXA5 Antikörper) regulates breast cancer cell survival and identifies a novel PP4c (zeige PPP4C Antikörper)-PEA15 signalling axis in the control of breast cancer cell survival.
PEA15 expression was not significantly correlated with ovarian cancer antineoplastic drug resistance.
Data suggest the role of the phospholipase C epsilon (zeige PLCL1 Antikörper)-Protein kinase D (zeige PRKD1 Antikörper)-PEA15 protein-ribosomal S6 kinase (zeige RPS6KB1 Antikörper)-IkappaB-NF-kappa B (zeige NFKB1 Antikörper) pathway in facilitating inflammation and inflammation-associated carcinogenesis in the colon.
Integrin alpha5beta1 and p53 (zeige TP53 Antikörper) convergent pathways in the control of anti-apoptotic proteins PEA-15 and survivin (zeige BIRC5 Antikörper) in high-grade glioma.
High PED expression is associated with esophageal carcinoma.
The nuclear translocation of SApErk1/ 2 apart from PEA-15 as an important mechanism to reverse senescence phenotype.
Latent HCMV infection of CD34 (zeige CD34 Antikörper) + cells protects cells from FAS (zeige FAS Antikörper)-mediated apoptosis through the cellular IL-10 (zeige IL10 Antikörper)/PEA-15 pathway.
New therapeutic targets based around PEA-15 and its associated interactions are now being uncovered and could provide novel avenues for treatment strategies in multiple diseases.
PED/PEA-15 overexpression is sufficient to block hydrogen peroxide-induced apoptosis in Ins-1E cells through a PLD-1 mediated mechanism
Omi/HtrA2 (zeige HTRA2 Antikörper) overexpression promotes hepatocellular carcinoma cell apoptosis and the ped/pea-15 expression level causes this difference of the Omi/HtrA2 (zeige HTRA2 Antikörper) pro-apoptotic marker in the various hepatocellular carcinoma cell lines
Data suggest that PEA-15 contributes to the specification of the cytokine pattern of activated Th cells, thus highlighting a potential new target to interfere with T cell functional polarization and subsequent immune response.
Activated astrocytes are known to clear the Abeta (zeige APP Antikörper) deposited in the extracellular milieu, which is why they play a key role in regulating the progression of Alzheimer's disease (AD).
Activation of peroxisome proliferator-activated receptor-gamma (PPARgamma (zeige PPARG Antikörper)) represses transcription of the ped/pea-15 gene.
The findings revealed a novel mechanism by which PEA-15 positively regulates Ras/ERK signaling and increases the proliferation of H-Ras-transformed epithelial cells through enhanced phospholipase D1 expression and activation.
PEA-15 did not differentiate and showed markedly enhanced autophagy. In these same cells, the autophagy inhibitor 3 (zeige PPP1R11 Antikörper)-methyladenine rescued TGF-beta1 (zeige TGFB1 Antikörper) effect on both autophagy and myogenesis, indicating that PEA-15 mediates TGF-beta1 (zeige TGFB1 Antikörper) effects in muscle.
Data suggest that PED/PEA-15 may affect fibroblast motility by a mechanism, at least in part, mediated by ERK1/2 (zeige MAPK1/3 Antikörper).
we propose that PEA-15 represents a novel point of convergence of the protein kinas C and MAPK/ERK (zeige MAPK1 Antikörper) pathways under gonadotropin releasing hormone stimulation
PEA-15 regulates T-cell proliferation
PEA-15 inhibits tumorigenesis in an MDA-MB-468 triple-negative breast cancer xenograft model through increased cytoplasmic localization of activated extracellular signal-regulated kinase.
This gene encodes a death effector domain-containing protein, which is a major phosphoprotein in astrocytes, and an endogenous substrate for protein kinase C. Studies using knockout mice suggest that this protein may protect astrocytes from TNF-induced apoptosis. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake.
15 kDa phosphoprotein enriched in astrocytes
, Phosphoprotein enriched in astrocytes, 15kD
, astrocytic phosphoprotein PEA-15
, homolog of mouse MAT-1 oncogene
, phosphoprotein enriched in diabetes
, mammary transforming gene 1
, phosphoprotein enriched in astrocytes 15
, phosphoprotein enriched in astrocytes 15A
, Astrocytic phosphoprotein PEA-15