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The protein encoded by ATRX contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. Zusätzlich bieten wir Ihnen ATRX Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 104 products:
Human Polyclonal ATRX Primary Antibody für IHC, IHC (p) - ABIN4282398
Heaphy, de Wilde, Jiao, Klein, Edil, Shi, Bettegowda, Rodriguez, Eberhart, Hebbar, Offerhaus, McLendon, Rasheed, He, Yan, Bigner, Oba-Shinjo, Marie, Riggins, Kinzler, Vogelstein, Hruban, Maitra et al.: Altered telomeres in tumors with ATRX and DAXX mutations. ... in Science (New York, N.Y.) 2011
Zeige alle 16 Referenzen für 4282398
Human Monoclonal ATRX Primary Antibody für ELISA, WB - ABIN393693
Kernohan, Jiang, Tremblay, Bonvissuto, Eubanks, Mann, Bérubé: ATRX partners with cohesin and MeCP2 and contributes to developmental silencing of imprinted genes in the brain. in Developmental cell 2010
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Human Polyclonal ATRX Primary Antibody für ICC, IF - ABIN442805
Wille, Maurer, Piatti, Whittle, Rieder, Singewald, Lusser: Impaired Contextual Fear Extinction Learning is Associated with Aberrant Regulation of CHD-Type Chromatin Remodeling Factors. in Frontiers in behavioral neuroscience 2015
Zeige alle 2 Referenzen für 442805
Human Polyclonal ATRX Primary Antibody für IF, ELISA - ABIN1533739
Villard, Lossi, Cardoso, Proud, Chiaroni, Colleaux, Schwartz, Fontés: Determination of the genomic structure of the XNP/ATRX gene encoding a potential zinc finger helicase. in Genomics 1997
Human Polyclonal ATRX Primary Antibody für ELISA, WB - ABIN1450956
McKay, Troelstra, van der Spek, Kanaar, Smit, Hagemeijer, Bootsma, Hoeijmakers: Sequence conservation of the rad21 Schizosaccharomyces pombe DNA double-strand break repair gene in human and mouse. in Genomics 1997
Human Polyclonal ATRX Primary Antibody für FACS, WB - ABIN655910
Liu, Shete, Wang, El-Zein, Etzel, Liang, Armstrong, Tsavachidis, Gilbert, Aldape, Xing, Wu, Wei, Bondy: Gamma-radiation sensitivity and polymorphisms in RAD51L1 modulate glioma risk. in Carcinogenesis 2010
ATRX loss can be reliable for the pathogenesis of neuroendocrine pancreatic neoplasms.
Mutation in ATRX gene is associated with cancer more frequently in males.
Nek1 (zeige NEK1 Antikörper) phosphorylates Rad54 and regulates Rad51 (zeige RAD51 Antikörper) removal to orchestrate homologous recombination and replication fork stability.
Results suggest that cell cycle progression and proliferation of HeLa cells can be tightly controlled by the abundance of RAD51 (zeige RAD51 Antikörper) and RAD54 proteins, which are essential for the rapid response to postreplicative stress and DNA damage stress.
ATRX interacts with ZNF274 (zeige ZNF274 Antikörper), TRIM28 (zeige TRIM28 Antikörper) and SETDB1 (zeige SETDB1 Antikörper) and binds to the 3' exons of zinc finger genes that present an atypical H3K9me3/H3K36me3 chromatin signature. Depletion of ATRX or ZNF274 (zeige ZNF274 Antikörper) leads to decreased H3K9me3 levels at zinc finger genes and other atypical chromatin regions.
somatic mutations in the ATRX gene have been observed as recurrent alterations in both osteosarcoma and brain tumors. However, it is unclear if there is any association between osteosarcoma and germline ATRX mutations, specifically in patients with constitutional ATR-X syndrome.
AMab-6 sensitively detects ATRX in Western blot and immunohistochemical analyses, indicating that AMab-6 could become the standard marker to determine the ATRX mutation status of gliomas in immunohistochemical analyses
our study describes a novel missense mutation of the ATRX gene helicase domain, carried by three affected males of the two generations of the same family and segregated with intellectual deficiency, dysmorphism and behaviour disorder without alpha-thalassaemia and with non-skewed X-chromosome inactivation
ATRX mutation is associated with increased mutation rate at the single-nucleotide variant (SNV) level.
ATRX loss may predict better clinical outcome in astrocytoma patients with p53 (zeige TP53 Antikörper) overexpression as compared to patients with wild-type ATRX
Our study highlights the importance of the cooperation between Rad54 (zeige RAD54L Antikörper) and Mus81 (zeige MUS81 Antikörper) for mediating DNA DSB repair and restraining chromosome missegregation.
The long noncoding RNA, TERRA (zeige DMRT2 Antikörper) can bind both in cis (zeige CISH Antikörper) to telomeres and in trans to genic targets; a large network of interacting proteins was defined, including epigenetic factors, telomeric proteins, and the RNA helicase, ATRX. TERRA (zeige DMRT2 Antikörper) and ATRX share hundreds of target genes and are functionally antagonistic at these loci: whereas TERRA (zeige DMRT2 Antikörper) activates, ATRX represses gene expression.
The changes of ATRX distribution occur and partially correlate with the main stages of zygotic genome activation during mouse early development, butthese changes seem to be determined by other processes of structural and functional rearrangements of blastomere nuclei.
Daxx (zeige DAXX Antikörper) and Atrx safeguard the genome by silencing repetitive elements when DNA methylation (zeige HELLS Antikörper) levels are low.
A direct role of Atrx in the establishment and robust maintenance of heterochromatin is demonstrated.
We propose a model whereby ATRX-dependent deposition of H3.3 into heterochromatin is normally required to maintain the memory of silencing at imprinted loci.
ATRX promotes the incorporation of histone H3.3 (zeige H3F3A Antikörper) at particular transcribed genes and facilitates transcriptional elongation through G-rich sequences.
Using X chromosome inactivation as a model, study applied an unbiased proteomics approach to isolate Xist and PRC2 regulators and identified ATRX; ATRX functions as a high-affinity RNA-binding protein that directly interacts with RepA/Xist RNA to promote loading of PRC2 in vivo. Without ATRX, PRC2 cannot load onto Xist RNA nor spread in cis (zeige CISH Antikörper) along the X chromosome.
These results indicate that while ATRX plays limited roles during early stages of skeletal development, deficiency of the protein in adult tissues does not confer susceptibility to osteoarthritis.
The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.
ATP-dependent helicase ATRX
, DNA dependent ATPase and helicase
, X-linked helicase II
, X-linked nuclear protein
, Zinc finger helicase
, alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae)
, helicase 2, X-linked
, transcriptional regulator ATRX
, alpha thalassemia/mental retardation syndrome X-linked homolog
, helicase II
, HP1 alpha-interacting protein
, alpha thalassemia/mental retardation syndrome (X-linked)
, heterochromatin protein 2
, DNA repair and recombination protein RAD54-like
, RAD54 homolog