gamma-Glutamyl Carboxylase (GGCX) ELISA Kits

GGCX encodes an enzyme which catalyzes the posttranslational modification of vitamin K-dependent protein. Zusätzlich bieten wir Ihnen GGCX Antikörper (66) und GGCX Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
GGCX 2677 P38435
Anti-Maus GGCX GGCX 56316 Q9QYC7
Anti-Ratte GGCX GGCX 81716 O88496
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Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Human 0.08 ng/mL   96 Tests Anmelden zum Anzeigen 13 bis 16 Tage

Weitere ELISA Kits für GGCX Interaktionspartner

Human gamma-Glutamyl Carboxylase (GGCX) Interaktionspartner

  1. 2 causative GGCX mutations ( c.1889-6G>A and c.1657delA) from the first reported clinical case of a VKCFD patient. The intronic mutation c.1889-6G>A affects GGCX splicing. Functional characterization of these 2 mutations suggests that truncation of GGCX from its C-terminus affects not only substrate binding but also protein stability.

  2. impact of CYP4F2 (zeige CYP4F2 ELISA Kits), ABCB1 (zeige ABCB1 ELISA Kits), and GGCX polymorphisms on bleeding episodes associated with acenocoumarol in Russian patients with atrial fibrillation

  3. this systematic review suggests that there indeed may be genotype-phenotype correlations for GGCX-related phenotypes, which can guide patient counseling and management.

  4. 529 adults (n = 325 European-Americans, 204 Egyptians) on a stable warfarin dose were genotyped for GGCX rs12714145 and rs10654848, FPGS (zeige FPGS ELISA Kits) rs7856096, and STX1B (zeige STX1B ELISA Kits) rs4889606.

  5. GGCX c.2084+45G polymorphisms has a moderate effect on VKAs dose requirements in Slavic population from Central-Eastern Europe.

  6. Detected are ten mutations in the gamma-glutamyl carboxylase gene in patients with hereditary deficiency of vitamin K-dependent coagulation factors.

  7. The allele frequency for GGCX 12970 C > G is 1.43 in north Indians and did not have a significant bearing on the maintenance dose of acenocoumarol oral anticoagulant in cardiac valve replacement patients.

  8. GGCX mutation found in families with pseudoxanthoma elasticum with retinitis pigmentosa and cutis laxa.

  9. These findings indicate that individuals carrying the CYP2C19 (zeige CYP2C19 ELISA Kits) rs3814637CC or CYP2C9 (zeige CYP2C9 ELISA Kits) rs1057910AA or GGCX rs699664AA genotype needed higher warfarin doses in the Chinese population.

  10. In atrial fibrillation population in Xinjiang, patients with CT and TT genotypes in the gamma-glutamyl carboxylase gene rs259251 loci required significantly higher warfarin dose than those with CC genotype.

Mouse (Murine) gamma-Glutamyl Carboxylase (GGCX) Interaktionspartner

  1. GGCX in osteoblasts functions to prevent abnormal mineralization in bone formation.

  2. findings suggest that GGCX expressed in osteoblasts is critical for the maintenance of blood glucose and WAT

  3. OCN is gamma-carboxylated by the gamma-carboxylase (GGCX) on three glutamic acid residues, a cellular process requiring reduction of vitamin K by a second enzyme, VKORC1 (zeige VKORC1 ELISA Kits).

  4. Ggcx(Deltaliver/Deltaliver) mice displayed bleeding diathesis.

  5. Effect of vitamin K-dependent protein precursor propeptide, vitamin K hydroquinone, and glutamate (zeige GRIN1 ELISA Kits) substrate binding on the structure and function of {gamma}-glutamyl carboxylase.

  6. These findings suggest a role for both the GGCX gene and the genetic background as well as dietary factors in modulating the phenotypic severity of Pseudoxanthoma elasticum caused by loss-of-function mutations in ABCC6 (zeige ABCC6 ELISA Kits).

  7. Analysis of a Ggcx(+/-) intercross revealed a partial developmental block with only 50% of expected Ggcx(-/-) offspring surviving to term, with the latter animals dying uniformly at birth of massive intra-abdominal hemorrhage

GGCX Antigen-Profil

Beschreibung des Gens

This gene encodes an enzyme which catalyzes the posttranslational modification of vitamin K-dependent protein. Many of these vitamin K-dependent proteins are involved in coagulation so the function of the encoded enzyme is essential for hemostasis. Mutations in this gene are associated with vitamin K-dependent coagulation defect and PXE-like disorder with multiple coagulation factor deficiency. Multiple transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit GGCX

  • gamma-glutamyl carboxylase (GGCX) Antikörper
  • gamma-glutamyl carboxylase (ggcx) Antikörper
  • gamma-glutamyl carboxylase (GC) Antikörper
  • gamma-glutamyl carboxylase (sce5891) Antikörper
  • gamma-glutamyl carboxylase L homeolog (ggcx.L) Antikörper
  • gamma-glutamyl carboxylase (Ggcx) Antikörper
  • cb751 Antikörper
  • CG13927 Antikörper
  • dgammaC Antikörper
  • dGC Antikörper
  • Dmel\\CG13927 Antikörper
  • gammaC Antikörper
  • GGC Antikörper
  • ggcx Antikörper
  • si:ch1073-230p18.3 Antikörper
  • VKCFD1 Antikörper
  • zgc:158736 Antikörper

Bezeichner auf Proteinebene für GGCX

gamma-glutamyl carboxylase , vitamin K-dependent gamma-carboxylase , peptidyl-glutamate 4-carboxylase , vitamin K gamma glutamyl carboxylase , CG13927-PA , CG13927-PB , GC-PA , GC-PB , gamma-glutamyl-carboxylase , gamma glutamyl carboxylase

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557240 Danio rerio
695628 Macaca mulatta
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100144666 Xenopus (Silurana) tropicalis
100171564 Pongo abelii
38194 Drosophila melanogaster
5810488 Sorangium cellulosum So ce56
444473 Xenopus laevis
2677 Homo sapiens
281190 Bos taurus
56316 Mus musculus
81716 Rattus norvegicus
475769 Canis lupus familiaris
443129 Ovis aries
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