anti-beta-Site APP-Cleaving Enzyme 2 (BACE2) Antikörper

Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Zusätzlich bieten wir Ihnen beta-Site APP-Cleaving Enzyme 2 Kits (31) und beta-Site APP-Cleaving Enzyme 2 Proteine (14) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
BACE2 25825 Q9Y5Z0
BACE2 56175 Q9JL18
BACE2 288227 Q6IE75
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Top anti-beta-Site APP-Cleaving Enzyme 2 Antikörper auf antikoerper-online.de

Showing 10 out of 151 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert EIA, WB 0.4 mL Anmelden zum Anzeigen 7 bis 9 Tage
407,00 €
Details
Human Kaninchen Unkonjugiert FACS, WB The anti-BACE2 Ctr Pab (ABIN390067) is used in Western blot to detect BACE2 in HL60 cell lysate. Flow cytometric analysis of HL-60 cells using BACE2 Antibody (Center)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-BACE2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: ACHN cell lysate WB Suggested Anti-BACE2  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.2500  Positive Control: ACHN cell lysate  BACE2 is supported by BioGPS gene expression data to be expressed in ACHN 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-BACE2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: PANC1 cell lysate 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB 0.4 mL Anmelden zum Anzeigen 7 bis 9 Tage
407,00 €
Details
Human Kaninchen Unkonjugiert EIA, WB   0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
462,00 €
Details
Human Kaninchen Unkonjugiert IHC (p), WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
517,00 €
Details
Human Kaninchen Unkonjugiert IF (p), IHC (p) Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti-BACE2 Polyclonal Antibody, Unconjugated (ABIN2170478) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Anmelden zum Anzeigen 18 bis 22 Tage
304,36 €
Details
Human Kaninchen Unkonjugiert EIA, WB   0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
462,00 €
Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
517,00 €
Details

BACE2 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-beta-Site APP-Cleaving Enzyme 2 Antikörper

  1. Human Polyclonal BACE2 Primary Antibody für EIA, WB - ABIN492803 : Sun, He, Song: BACE2, as a novel APP theta-secretase, is not responsible for the pathogenesis of Alzheimer's disease in Down syndrome. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006 (PubMed)
    Zeige alle 3 Referenzen für 492803

  2. Human Polyclonal BACE2 Primary Antibody für EIA, WB - ABIN358600 : Basi, Frigon, Barbour, Doan, Gordon, McConlogue, Sinha, Zeller: Antagonistic effects of beta-site amyloid precursor protein-cleaving enzymes 1 and 2 on beta-amyloid peptide production in cells. in The Journal of biological chemistry 2003 (PubMed)
    Zeige alle 3 Referenzen für 358600

  3. Human Polyclonal BACE2 Primary Antibody für EIA, WB - ABIN492805 : Lahiri, Maloney, Ge: Functional domains of the BACE1 and BACE2 promoters and mechanisms of transcriptional suppression of the BACE2 promoter in normal neuronal cells. in Journal of molecular neuroscience : MN 2006 (PubMed)
    Zeige alle 3 Referenzen für 492805

  4. Human Polyclonal BACE2 Primary Antibody für FACS, WB - ABIN390067 : Shi, Tugusheva, Bruce, Lucka, Wu, Chen-Dodson, Price, Li, Xu, Huang, Sardana, Hazuda: Beta-secretase cleavage at amino acid residue 34 in the amyloid beta peptide is dependent upon gamma-secretase activity. in The Journal of biological chemistry 2003 (PubMed)
    Zeige alle 2 Referenzen für 390067

Weitere Antikörper gegen beta-Site APP-Cleaving Enzyme 2 Interaktionspartner

Human beta-Site APP-Cleaving Enzyme 2 (BACE2) Interaktionspartner

  1. the behavior of the flap (zeige ALOX5AP Antikörper) tips during simulations is different between BACE1 (zeige BACE Antikörper) and BACE2. The BACE1 (zeige BACE Antikörper) active site cavity is more spacious as compared to that of BACE2. The analysis of 10S loop and 113S loop showed a similar trend to that of flaps, with the BACE1 (zeige BACE Antikörper) loops being more flexible and less stable than those of BACE2

  2. RNA-seq evidence of biallelic expression of BACE2 and 10 neighboring genes in at least one primary human tissue tested indicates that the expression of BACE2 is uncoupled from the control of the maternally inherited 5mCpG imprints at the WRB (zeige WRB Antikörper) differentially methylated region (DMR (zeige WDR20 Antikörper)) in disomic controls or trisomy (Down syndrome) individuals.

  3. Studies suggest that beta-Secretases BACE1 (zeige BACE Antikörper)/2 plays an important role in retinal homeostasis and that BACE (zeige BACE Antikörper) upregulation in response to stress is a protective measure.

  4. Data suggest that the amino acid residues would be essential for selectivity of beta-amyloid precursor protein cleavage enzymes BACE1 (zeige BACE Antikörper) and BACE2 functions and could be sites for the design of selective inhibitors targeting either BACE1 (zeige BACE Antikörper) or BACE2.

  5. Data identified two novel genome-wide significant associations: 2-h plasma glucose and HKDC1, and fasting C-peptide and BACE2.

  6. BACE2 cle (zeige BACE Antikörper)aves the integral membrane form (zeige PMEL Antikörper) of PMEL within the juxtamembrane domain, releasing the PMEL luminal domain into endosomal precursors for (zeige BACE Antikörper) the formation of amyloid fibrils and downstream melanosome morphogenesis.

  7. Inhibiting Chrna7 (zeige CHRNA7 Antikörper) expression markedly stimulated the production of Abeta (zeige APP Antikörper) through the mechanism of increased expression of BACE1 (zeige BACE Antikörper) and inhibited expression of BACE2 in SH-SY5Y cells.

  8. BACE2 overexpression in cultured cells was found to lower net amyloid ss-protein levels.

  9. The BACE2 distal promoter contains an activating cis (zeige CISH Antikörper)-regulatory element that is responsive to Trichostatin A (TSA (zeige PRDX2 Antikörper)) treatment according to promoter reporter assays in HEK (zeige EPHA3 Antikörper) 293 cells.

  10. All these data point to a role for BACE2 in the IRbeta trafficking and insulin (zeige INS Antikörper) signaling. In conclusion, BACE2 is hereby presented as an important enzyme in beta-cell function.

Mouse (Murine) beta-Site APP-Cleaving Enzyme 2 (BACE2) Interaktionspartner

  1. The absence of BACE2 ameliorates glucose tolerance defects induced by IAPP (zeige IAPP Antikörper) overexpression in the beta-cell and promotes beta-cell survival.

  2. the BACE1 (zeige BACE Antikörper) homologue BACE2 processes PMEL (zeige PMEL Antikörper) to generate functional amyloids. BACE2 is highly expressed in pigment cells and Bace2(-/-) but not Bace1 (zeige BACE Antikörper)(-/-) mice display coat color defects, implying a specific role for BACE2 during melanogenesis

  3. non-redundant roles of BACE1 (zeige BACE Antikörper)/2 in ectodomain shedding with BACE1 (zeige BACE Antikörper) regulating a broader and BACE2 a more distinct set of beta-cell-enriched substrates including two proteins of the seizure 6 protein (zeige SEZ6L Antikörper) family (SEZ6L (zeige SEZ6L Antikörper) and SEZ6L2 (zeige SEZ6L2 Antikörper)).

  4. Tmem27 (zeige TMEM27 Antikörper) dimerization is a dynamic process involving Bace2

  5. Bace2 is a beta (zeige SUCLA2 Antikörper) cell-enriched protease that regulates pancreatic beta cell function and mass.

  6. The TgBACE2-APP (zeige APP Antikörper) mice showed deregulation of BACE2 expression levels that were significantly increased with respect to single TgBACE2 mice.

  7. Data show that BACE1 (zeige BACE Antikörper) knockout mice display a complex phenotype, and a combined deficiency of BACE2 and BACE1 (zeige BACE Antikörper) enhanced the bace1 (zeige BACE Antikörper)-/- lethality.

  8. BACE1 (zeige BACE Antikörper) and BACE2 may act as alternative alpha-secretase-like proteases in proteolytic processing of IL-1R2 and APP (zeige APP Antikörper)

  9. The presence of BACE2 in secretory granules of beta cells suggests that it may play a role in diabetes-associated amyloidogenesis.

beta-Site APP-Cleaving Enzyme 2 (BACE2) Antigen-Profil

Protein Überblick

Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by this gene. This gene localizes to the 'Down critical region' of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease. Three transcript variants encoding different isoforms have been described for this gene.

Genbezeichner und Symbole assoziert mit BACE2

  • beta-site APP-cleaving enzyme 2 (BACE2) Antikörper
  • beta-site APP-cleaving enzyme 2 (Bace2) Antikörper
  • beta-site APP-cleaving enzyme 2 (LOC100342092) Antikörper
  • 1110059C24Rik Antikörper
  • AEPLC Antikörper
  • AI850424 Antikörper
  • ALP56 Antikörper
  • ARP1 Antikörper
  • ASP1 Antikörper
  • ASP21 Antikörper
  • BAE2 Antikörper
  • CDA13 Antikörper
  • CEAP1 Antikörper
  • DRAP Antikörper

Bezeichner auf Proteinebene für BACE2

56 kDa aspartic-like protease , Down syndrome region aspartic protease , aspartyl protease 1 , beta-secretase 2 , beta-site amyloid beta A4 precursor protein-cleaving enzyme 2 , memapsin-1 , membrane-associated aspartic protease 1 , theta-secretase , transmembrane aspartic proteinase Asp1 , ASP1 , asp 1 , beta-site APP cleaving enzyme 2 , beta-site amyloid precursor protein cleaving enzyme 2

GENE ID SPEZIES
25825 Homo sapiens
56175 Mus musculus
288227 Rattus norvegicus
100342092 Oryctolagus cuniculus
100720853 Cavia porcellus
100517374 Sus scrofa
478418 Canis lupus familiaris
534774 Bos taurus
418526 Gallus gallus
101102027 Ovis aries
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