beta-Site APP-Cleaving Enzyme 1 (BACE) ELISA Kits

Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Zusätzlich bieten wir Ihnen beta-Site APP-Cleaving Enzyme 1 Antikörper (267) und beta-Site APP-Cleaving Enzyme 1 Proteine (34) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
BACE 23821 P56818
BACE 29392 P56819
BACE 23621 P56817
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Top beta-Site APP-Cleaving Enzyme 1 ELISA Kits auf antikoerper-online.de

Showing 10 out of 56 products:

Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Human 0.78 pg/mL 3.12-200 pg/mL Typical standard curve 96 Tests Anmelden zum Anzeigen 11 bis 15 Tage
874,71 €
Details
Maus 14.1 pg/mL 31.25-2000 pg/mL 96 Tests Anmelden zum Anzeigen 11 bis 15 Tage
548,57 €
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Ratte 6.7 pg/mL 15.62-1000 pg/mL 96 Tests Anmelden zum Anzeigen 11 bis 15 Tage
579,05 €
Details
Human 1.0 ng/mL 1.0-250 ng/mL 96 Tests Anmelden zum Anzeigen 6 bis 8 Tage
556,29 €
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Human 0.31 ng/mL 0.78-50.0 ng/mL   96 Tests Anmelden zum Anzeigen 6 bis 8 Tage
653,71 €
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Maus 0.78-50 ng/mL   96 Tests Anmelden zum Anzeigen 6 bis 8 Tage
653,71 €
Details
Kaninchen 0.938 ng/mL 1.563-100 ng/mL   96 Tests Anmelden zum Anzeigen 10 bis 13 Tage
666,67 €
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Huhn 0.938 ng/mL 1.563-100 ng/mL   96 Tests Anmelden zum Anzeigen 10 bis 13 Tage
666,67 €
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Meerschweinchen 0.188 ng/mL 0.313-20 ng/mL   96 Tests Anmelden zum Anzeigen 10 bis 13 Tage
666,67 €
Details
Affe 0.375 ng/mL 0.625-40 ng/mL   96 Tests Anmelden zum Anzeigen 10 bis 13 Tage
666,67 €
Details

Am meisten referenzierte beta-Site APP-Cleaving Enzyme 1 ELISA Kits

  1. Human BACE ELISA Kit für Sandwich ELISA - ABIN365021 : Qian, Ding, Cheng, Zhu, Zhao, Jin, Guan, Zhang, Chen, Xu: Early biomarkers for post-stroke cognitive impairment. in Journal of neurology 2012 (PubMed)

Weitere ELISA Kits für beta-Site APP-Cleaving Enzyme 1 Interaktionspartner

Mouse (Murine) beta-Site APP-Cleaving Enzyme 1 (BACE) Interaktionspartner

  1. In conclusion, glucocorticoid couples mGR (zeige GRHL1 ELISA Kits) with Galphas (zeige GNAS ELISA Kits) and triggers cAMP-PKA-CREB (zeige CREB1 ELISA Kits) axis dependent on the lipid raft to stimulate BACE1 upregulation and Abeta (zeige APP ELISA Kits) generation.SIGNIFICANCE STATEMENT Patients with Alzheimer's disease (AD) have been growing sharply and stress is considered as the major environment factor of AD.

  2. study supports the hypothesis that Abeta (zeige APP ELISA Kits) induces microtubule disruption in presynaptic dystrophic neurites that surround plaques, thus impairing axonal transport and leading to accumulation of BACE1 and exacerbation of amyloid pathology in Alzheimer's disease

  3. Here, we demonstrate that Snapin (zeige SNAPIN ELISA Kits)-mediated retrograde transport plays a critical role in removing BACE1 from presynaptic terminals toward the soma, thus reducing synaptic Abeta (zeige APP ELISA Kits) production. Adeno (zeige ADORA2A ELISA Kits)-associated virus-mediated Snapin (zeige SNAPIN ELISA Kits) overexpression in the hippocampus of mutant hAPP mice significantly decreases synaptic Abeta (zeige APP ELISA Kits) levels, attenuates synapse loss, and thus rescues cognitive deficits. Our study uncovers a new pathway...

  4. beta-site APP cleaving enzyme 1 (BACE1) is essential for amyloid beta protein production. We discovered that A673V mutation shifted the BACE1 cleavage site from the Glu (zeige GCG ELISA Kits)(11) to the Asp(1 (zeige BACE2 ELISA Kits)) site, resulting in much higher C99 level and C99/C89 ratio.

  5. SEPT8 (zeige SEPT8 ELISA Kits) modulates beta-amyloidogenic processing of APP (zeige APP ELISA Kits) through a mechanism affecting the intracellular sorting and accumulation of BACE1.

  6. the depletion of BIN1 (zeige BIN1 ELISA Kits) increases cellular BACE1 levels through impaired endosomal trafficking and reduces BACE1 lysosomal degradation, resulting in increased Ab production. Our findings provide a mechanistic role of BIN1 (zeige BIN1 ELISA Kits) in the pathogenesis of Alzheimer disease (AD), as a novel genetic regulator of BACE1 levels and Ab production

  7. In an Alzheimer's disease mouse model we show that BACE-1 is upregulated at the blood-brain barrier compared to healthy controls.

  8. study provides new insights into autophagy-mediated regulation of BACE1 turnover and APP (zeige APP ELISA Kits) processing, thus building a foundation for future development of potential Alzheimer's disease therapeutic strategies.

  9. analysis suggests that some familial Alzheimer's disease mutations in APP (zeige APP ELISA Kits) are amyloidogenic and/or amyloidolytic via selection of alternative BACE1 cleavage sites

  10. data indicate that Egr-1 (zeige EGR1 ELISA Kits) promotes Abeta (zeige APP ELISA Kits) synthesis via transcriptional activation of BACE-1 and suggest that Egr-1 (zeige EGR1 ELISA Kits) plays role in activation of BACE-1 and acceleration of Abeta (zeige APP ELISA Kits) synthesis in AD brain.

Human beta-Site APP-Cleaving Enzyme 1 (BACE) Interaktionspartner

  1. Data suggest that trimerization of BACE1 requires transmembrane sequences (TMSs) and cytoplasmic domains, with residues Ala463 and Cys466 buried within trimer interface of the sulfur-rich core of TMSs; BACE1 appears to play role in compartmentalization of intracellular copper by transferring cytosolic copper to intracellular compartments.

  2. SEPT8 (zeige SEPT8 ELISA Kits) modulates beta-amyloidogenic processing of APP (zeige APP ELISA Kits) through a mechanism affecting the intracellular sorting and accumulation of BACE1.

  3. the depletion of BIN1 (zeige BIN1 ELISA Kits) increases cellular BACE1 levels through impaired endosomal trafficking and reduces BACE1 lysosomal degradation, resulting in increased Ab production. Our findings provide a mechanistic role of BIN1 (zeige BIN1 ELISA Kits) in the pathogenesis of Alzheimer disease (AD), as a novel genetic regulator of BACE1 levels and Ab production

  4. in vitro BACE1-activity assays demonstrate that palmitoylation-dependent dimerization of APP (zeige APP ELISA Kits) promotes beta-cleavage of APP (zeige APP ELISA Kits) in lipid-rich detergent resistant cell membranes (DRMs), when compared to total APP (zeige APP ELISA Kits).

  5. The circular RNA ciRS-7 promotes APP (zeige APP ELISA Kits) and BACE1 degradation in an NF-kappaB (zeige NFKB1 ELISA Kits)-dependent manner.

  6. rs638405 in BACE1 was not associated with the risk of Alzheimer's disease (AD), rs638405 decreased the risk of apolipoprotein-E (zeige APOE ELISA Kits) epsilon4 (APOE4) positive AD patients, rs638405 also decreased the risk of Asian AD patients. Data of meta-analysis suggested rs638405 in BACE1 was a protective factor of AD.

  7. analysis suggests that some familial Alzheimer's disease mutations in APP (zeige APP ELISA Kits) are amyloidogenic and/or amyloidolytic via selection of alternative BACE1 cleavage sites

  8. In this study, we aimed to investigate the association of BACE1 rs490460 with the risk of Schizophrenia in an Iranian population. A significant association was observed between the rs490460 T allele and Schizophrenia ( p = 0.0002, odds ratio 0.69, 95% confidence interval 0.57-0.84).

  9. findings demonstrate that USP8 (zeige USP8 ELISA Kits) plays a key role in the trafficking and degradation of BACE1 by deubiquitinating lysine 501.

  10. Cassia obtusifolia extract and its major constituents are potent BACE1 inhibitors.

Zebrafish beta-Site APP-Cleaving Enzyme 1 (BACE) Interaktionspartner

  1. bace1 mutants display hypomyelination in the peripheral nervous system and supernumerary neuromasts while in bace2 (zeige BACE2 ELISA Kits) mutants the shape and migration of melanocytes is affected.

beta-Site APP-Cleaving Enzyme 1 (BACE) Antigen-Profil

Beschreibung des Gens

Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene.

Genbezeichner und Symbole assoziert mit BACE

  • beta-site APP-cleaving enzyme 1 (BACE1) Antikörper
  • beta-site APP-cleaving enzyme 1 (MGC145931) Antikörper
  • beta-site APP-cleaving enzyme 1 (LOC100232107) Antikörper
  • beta-site APP-cleaving enzyme 2 (bace2) Antikörper
  • beta-site APP-cleaving enzyme 2 (BACE2) Antikörper
  • beta-site APP-cleaving enzyme 2 (LOC100224177) Antikörper
  • beta-site APP cleaving enzyme 1 (Bace1) Antikörper
  • beta-site APP-cleaving enzyme 1 (bace1) Antikörper
  • ASP2 Antikörper
  • BACE Antikörper
  • BACE1 Antikörper
  • BACE2 Antikörper
  • C76936 Antikörper
  • HSPC104 Antikörper
  • MGC68482 Antikörper
  • MGC68881 Antikörper
  • MGC145931 Antikörper
  • zgc:77409 Antikörper

Bezeichner auf Proteinebene für BACE

beta-site APP-cleaving enzyme 1 , beta-secretase 1 , beta-secretase 1 isoform A preproprotein , beta-secretase 1 isoform B preproprotein , beta-secretase 1 isoform C preproprotein , beta-secretase 1-like , beta-site APP-cleaving enzyme 2 , beta-secretase 2-like , APP beta-secretase , ASP2 , asp 2 , aspartyl protease 2 , beta-site amyloid precursor protein cleaving enzyme 1 , memapsin-2 , membrane-associated aspartic protease 2 , beta-secretase 1 precursor variant 1 , beta-site APP cleaving enzyme 1 , beta-site amyloid beta A4 precursor protein-cleaving enzyme , transmembrane aspartic proteinase Asp2 , beta-site APP cleaving enzyme , beta secretase 1

GENE ID SPEZIES
100071137 Equus caballus
451573 Pan troglodytes
697694 Macaca mulatta
779940 Xenopus (Silurana) tropicalis
100025518 Monodelphis domestica
100232107 Taeniopygia guttata
100459804 Pongo abelii
380307 Xenopus laevis
398806 Xenopus laevis
747819 Pan troglodytes
100016587 Monodelphis domestica
100216145 Xenopus (Silurana) tropicalis
100224177 Taeniopygia guttata
100406072 Callithrix jacchus
100602656 Nomascus leucogenys
23821 Mus musculus
29392 Rattus norvegicus
100135485 Cavia porcellus
23621 Homo sapiens
614333 Bos taurus
403005 Danio rerio
419768 Gallus gallus
489390 Canis lupus familiaris
100511707 Sus scrofa
100343442 Oryctolagus cuniculus
101119667 Ovis aries
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