anti-beta-Site APP-Cleaving Enzyme 1 (BACE) Antikörper

Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Zusätzlich bieten wir Ihnen beta-Site APP-Cleaving Enzyme 1 Kits (56) und beta-Site APP-Cleaving Enzyme 1 Proteine (34) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
BACE 23821 P56818
BACE 29392 P56819
BACE 23621 P56817
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Top anti-beta-Site APP-Cleaving Enzyme 1 Antikörper auf antikoerper-online.de

Showing 10 out of 267 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert IF, IHC, WB WB Suggested Anti-BACE1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Human Liver 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB 0.4 mL Anmelden zum Anzeigen 7 bis 9 Tage
407,00 €
Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB 0.4 mL Anmelden zum Anzeigen 7 bis 9 Tage
407,00 €
Details
Human Kaninchen Unkonjugiert WB Western blot analysis of anti-BACE Antibody (S498) (ABIN392200) in mouse cerebellum tissue lysates (35 µg/lane). BACE (arrow) was detected using the purified polyclonal antibody. 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
Details
Human Kaninchen Unkonjugiert IHC (p), WB Western blot analysis of anti-BACE1 Antibody (N-term) (ABIN392201) in mouse heart tissue lysates (35 µg/lane). BACE1(arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human brain tissue reacted with BACE1 antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
Details
Human Kaninchen Unkonjugiert IHC (p), WB The anti-Phospho-BACE-S498 Pab (ABIN389517) is used in Western blot to detect Phospho-BACE-S498 in mouse brain tissue lysate Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
Details
Human Kaninchen Unkonjugiert EIA, WB 0.4 mL Anmelden zum Anzeigen 7 bis 9 Tage
407,00 €
Details
Human Kaninchen Unkonjugiert IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti BACE1/ASP2 Polyclonal Antibody, Unconjugated (ABIN725705) at 1:200 followed by conjugation to the secondary antibody and DAB staining L1 rat brain lysates probed with Anti BACE1/ASP2 Polyclonal Antibody, Unconjugated (ABIN725705) at 1:200 overnight at 4 °C. Followed by conjugation to secondary antibody at 1:3000 for 90 min at 37 °C. Predicted band 51kD. Observed band size:51kD. 100 μL Anmelden zum Anzeigen 9 bis 12 Tage
315,94 €
Details
Human Kaninchen Unkonjugiert IHC (p), WB 0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
440,00 €
Details
Human Kaninchen Unkonjugiert WB 0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
484,00 €
Details

BACE Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

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Am meisten referenzierte anti-beta-Site APP-Cleaving Enzyme 1 Antikörper

  1. Human Polyclonal BACE Primary Antibody für EIA, IHC (p) - ABIN358083 : Xie, Guo: PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein. in The Journal of biological chemistry 2005 (PubMed)
    Zeige alle 5 Referenzen für 358083

  2. Human Polyclonal BACE Primary Antibody für IHC (p), WB - ABIN392201 : He, Li, Chang, Tang: GGA proteins mediate the recycling pathway of memapsin 2 (BACE). in The Journal of biological chemistry 2005 (PubMed)
    Zeige alle 5 Referenzen für 392201

  3. Human Polyclonal BACE Primary Antibody für IHC (p), WB - ABIN401041 : Hussain, Powell, Howlett, Tew, Meek, Chapman, Gloger, Murphy, Southan, Ryan, Smith, Simmons, Walsh, Dingwall, Christie: Identification of a novel aspartic protease (Asp 2) as beta-secretase. in Molecular and cellular neurosciences 2000 (PubMed)
    Zeige alle 4 Referenzen für 401041

  4. Human Polyclonal BACE Primary Antibody für WB - ABIN264995 : Yan, Bienkowski, Shuck, Miao, Tory, Pauley, Brashier, Stratman, Mathews, Buhl, Carter, Tomasselli, Parodi, Heinrikson, Gurney: Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity. in Nature 1999 (PubMed)
    Zeige alle 4 Referenzen für 264995

  5. Human Polyclonal BACE Primary Antibody für IF (p), IHC (p) - ABIN725705 : Tian, Guo, Wu, Ma, Zhao: Minocycline Alleviates Sevoflurane-Induced Cognitive Impairment in Aged Rats. in Cellular and molecular neurobiology 2015 (PubMed)
    Zeige alle 4 Referenzen für 725705

  6. Human Polyclonal BACE Primary Antibody für IHC (p), WB - ABIN389517 : Huang, Chang, Koelsch, Turner, Lupu, Tang: Internalization of exogenously added memapsin 2 (beta-secretase) ectodomain by cells is mediated by amyloid precursor protein. in The Journal of biological chemistry 2004 (PubMed)
    Zeige alle 4 Referenzen für 389517

  7. Human Polyclonal BACE Primary Antibody für WB - ABIN392200 : Chiocco, Kulnane, Younkin, Younkin, Evin, Lamb: Altered amyloid-beta metabolism and deposition in genomic-based beta-secretase transgenic mice. in The Journal of biological chemistry 2004 (PubMed)
    Zeige alle 4 Referenzen für 392200

  8. Cow (Bovine) Polyclonal BACE Primary Antibody für IF, IHC - ABIN2782766 : Shimizu, Tosaki, Kaneko, Hisano, Sakurai, Nukina: Crystal structure of an active form of BACE1, an enzyme responsible for amyloid beta protein production. in Molecular and cellular biology 2008 (PubMed)

Weitere Antikörper gegen beta-Site APP-Cleaving Enzyme 1 Interaktionspartner

Mouse (Murine) beta-Site APP-Cleaving Enzyme 1 (BACE) Interaktionspartner

  1. In conclusion, glucocorticoid couples mGR (zeige GRHL1 Antikörper) with Galphas (zeige GNAS Antikörper) and triggers cAMP-PKA-CREB (zeige CREB1 Antikörper) axis dependent on the lipid raft to stimulate BACE1 upregulation and Abeta (zeige APP Antikörper) generation.SIGNIFICANCE STATEMENT Patients with Alzheimer's disease (AD) have been growing sharply and stress is considered as the major environment factor of AD.

  2. study supports the hypothesis that Abeta (zeige APP Antikörper) induces microtubule disruption in presynaptic dystrophic neurites that surround plaques, thus impairing axonal transport and leading to accumulation of BACE1 and exacerbation of amyloid pathology in Alzheimer's disease

  3. Here, we demonstrate that Snapin (zeige SNAPIN Antikörper)-mediated retrograde transport plays a critical role in removing BACE1 from presynaptic terminals toward the soma, thus reducing synaptic Abeta (zeige APP Antikörper) production. Adeno (zeige ADORA2A Antikörper)-associated virus-mediated Snapin (zeige SNAPIN Antikörper) overexpression in the hippocampus of mutant hAPP mice significantly decreases synaptic Abeta (zeige APP Antikörper) levels, attenuates synapse loss, and thus rescues cognitive deficits. Our study uncovers a new pathway...

  4. beta-site APP cleaving enzyme 1 (BACE1) is essential for amyloid beta protein production. We discovered that A673V mutation shifted the BACE1 cleavage site from the Glu (zeige GCG Antikörper)(11) to the Asp(1 (zeige BACE2 Antikörper)) site, resulting in much higher C99 level and C99/C89 ratio.

  5. SEPT8 (zeige SEPT8 Antikörper) modulates beta-amyloidogenic processing of APP (zeige APP Antikörper) through a mechanism affecting the intracellular sorting and accumulation of BACE1.

  6. the depletion of BIN1 (zeige BIN1 Antikörper) increases cellular BACE1 levels through impaired endosomal trafficking and reduces BACE1 lysosomal degradation, resulting in increased Ab production. Our findings provide a mechanistic role of BIN1 (zeige BIN1 Antikörper) in the pathogenesis of Alzheimer disease (AD), as a novel genetic regulator of BACE1 levels and Ab production

  7. In an Alzheimer's disease mouse model we show that BACE-1 is upregulated at the blood-brain barrier compared to healthy controls.

  8. study provides new insights into autophagy-mediated regulation of BACE1 turnover and APP (zeige APP Antikörper) processing, thus building a foundation for future development of potential Alzheimer's disease therapeutic strategies.

  9. analysis suggests that some familial Alzheimer's disease mutations in APP (zeige APP Antikörper) are amyloidogenic and/or amyloidolytic via selection of alternative BACE1 cleavage sites

  10. data indicate that Egr-1 (zeige EGR1 Antikörper) promotes Abeta (zeige APP Antikörper) synthesis via transcriptional activation of BACE-1 and suggest that Egr-1 (zeige EGR1 Antikörper) plays role in activation of BACE-1 and acceleration of Abeta (zeige APP Antikörper) synthesis in AD brain.

Human beta-Site APP-Cleaving Enzyme 1 (BACE) Interaktionspartner

  1. Study showed that serum deprivation enhances ADAM10 (zeige ADAM10 Antikörper)/17-mediated cleavage and secretion of enzymatically active BACE1. This could be the result of alterations in the lipid composition of the membrane that lead in disruption of membrane compartmentalization in lipid rafts and non-lipid rafts. At present the significance of BACE1 shedding in the development of Alzheimer's disease is unclear.

  2. Data suggest that trimerization of BACE1 requires transmembrane sequences (TMSs) and cytoplasmic domains, with residues Ala463 and Cys466 buried within trimer interface of the sulfur-rich core of TMSs; BACE1 appears to play role in compartmentalization of intracellular copper by transferring cytosolic copper to intracellular compartments.

  3. SEPT8 (zeige SEPT8 Antikörper) modulates beta-amyloidogenic processing of APP (zeige APP Antikörper) through a mechanism affecting the intracellular sorting and accumulation of BACE1.

  4. the depletion of BIN1 (zeige BIN1 Antikörper) increases cellular BACE1 levels through impaired endosomal trafficking and reduces BACE1 lysosomal degradation, resulting in increased Ab production. Our findings provide a mechanistic role of BIN1 (zeige BIN1 Antikörper) in the pathogenesis of Alzheimer disease (AD), as a novel genetic regulator of BACE1 levels and Ab production

  5. in vitro BACE1-activity assays demonstrate that palmitoylation-dependent dimerization of APP (zeige APP Antikörper) promotes beta-cleavage of APP (zeige APP Antikörper) in lipid-rich detergent resistant cell membranes (DRMs), when compared to total APP (zeige APP Antikörper).

  6. The circular RNA ciRS-7 promotes APP (zeige APP Antikörper) and BACE1 degradation in an NF-kappaB (zeige NFKB1 Antikörper)-dependent manner.

  7. rs638405 in BACE1 was not associated with the risk of Alzheimer's disease (AD), rs638405 decreased the risk of apolipoprotein-E (zeige APOE Antikörper) epsilon4 (APOE4) positive AD patients, rs638405 also decreased the risk of Asian AD patients. Data of meta-analysis suggested rs638405 in BACE1 was a protective factor of AD.

  8. analysis suggests that some familial Alzheimer's disease mutations in APP (zeige APP Antikörper) are amyloidogenic and/or amyloidolytic via selection of alternative BACE1 cleavage sites

  9. In this study, we aimed to investigate the association of BACE1 rs490460 with the risk of Schizophrenia in an Iranian population. A significant association was observed between the rs490460 T allele and Schizophrenia ( p = 0.0002, odds ratio 0.69, 95% confidence interval 0.57-0.84).

  10. findings demonstrate that USP8 (zeige USP8 Antikörper) plays a key role in the trafficking and degradation of BACE1 by deubiquitinating lysine 501.

Zebrafish beta-Site APP-Cleaving Enzyme 1 (BACE) Interaktionspartner

  1. bace1 mutants display hypomyelination in the peripheral nervous system and supernumerary neuromasts while in bace2 (zeige BACE2 Antikörper) mutants the shape and migration of melanocytes is affected.

beta-Site APP-Cleaving Enzyme 1 (BACE) Antigen-Profil

Protein Überblick

Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene.

Genbezeichner und Symbole assoziert mit BACE

  • beta-site APP-cleaving enzyme 1 (BACE1) Antikörper
  • beta-site APP-cleaving enzyme 1 (MGC145931) Antikörper
  • beta-site APP-cleaving enzyme 1 (LOC100232107) Antikörper
  • beta-site APP-cleaving enzyme 2 (bace2) Antikörper
  • beta-site APP-cleaving enzyme 2 (BACE2) Antikörper
  • beta-site APP-cleaving enzyme 2 (LOC100224177) Antikörper
  • beta-site APP cleaving enzyme 1 (Bace1) Antikörper
  • beta-site APP-cleaving enzyme 1 (bace1) Antikörper
  • ASP2 Antikörper
  • BACE Antikörper
  • BACE1 Antikörper
  • BACE2 Antikörper
  • C76936 Antikörper
  • HSPC104 Antikörper
  • MGC68482 Antikörper
  • MGC68881 Antikörper
  • MGC145931 Antikörper
  • zgc:77409 Antikörper

Bezeichner auf Proteinebene für BACE

beta-site APP-cleaving enzyme 1 , beta-secretase 1 , beta-secretase 1 isoform A preproprotein , beta-secretase 1 isoform B preproprotein , beta-secretase 1 isoform C preproprotein , beta-secretase 1-like , beta-site APP-cleaving enzyme 2 , beta-secretase 2-like , APP beta-secretase , ASP2 , asp 2 , aspartyl protease 2 , beta-site amyloid precursor protein cleaving enzyme 1 , memapsin-2 , membrane-associated aspartic protease 2 , beta-secretase 1 precursor variant 1 , beta-site APP cleaving enzyme 1 , beta-site amyloid beta A4 precursor protein-cleaving enzyme , transmembrane aspartic proteinase Asp2 , beta-site APP cleaving enzyme , beta secretase 1

GENE ID SPEZIES
100071137 Equus caballus
451573 Pan troglodytes
697694 Macaca mulatta
779940 Xenopus (Silurana) tropicalis
100025518 Monodelphis domestica
100232107 Taeniopygia guttata
100459804 Pongo abelii
380307 Xenopus laevis
398806 Xenopus laevis
747819 Pan troglodytes
100016587 Monodelphis domestica
100216145 Xenopus (Silurana) tropicalis
100224177 Taeniopygia guttata
100406072 Callithrix jacchus
100602656 Nomascus leucogenys
23821 Mus musculus
29392 Rattus norvegicus
100135485 Cavia porcellus
23621 Homo sapiens
614333 Bos taurus
403005 Danio rerio
419768 Gallus gallus
489390 Canis lupus familiaris
100511707 Sus scrofa
100343442 Oryctolagus cuniculus
101119667 Ovis aries
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