anti-beta-Site APP-Cleaving Enzyme 1 (BACE) Antikörper

Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Zusätzlich bieten wir Ihnen beta-Site APP-Cleaving Enzyme 1 Kits (59) und beta-Site APP-Cleaving Enzyme 1 Proteine (32) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
BACE 23621 P56817
BACE 23821 P56818
BACE 29392 P56819
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Top anti-beta-Site APP-Cleaving Enzyme 1 Antikörper auf antikoerper-online.de

Showing 10 out of 270 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert IF, IHC, WB <b>WB Suggested Anti-BACE1 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:62500<br><b>Positive Control: </b>Human Liver 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-Bace1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:1562500 Positive Control: Mouse Heart 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert WB Western blot analysis of anti-BACE Antibody (S498) (ABIN392200) in mouse cerebellum tissue lysates (35 µg/lane). BACE (arrow) was detected using the purified polyclonal antibody. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Kaninchen Unkonjugiert IHC (p), WB The anti-Phospho-BACE-S498 Pab (ABIN389517) is used in Western blot to detect Phospho-BACE-S498 in mouse brain tissue lysate Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert IHC (p), WB Western blot analysis of anti-BACE1 Antibody (N-term) (ABIN392201) in mouse heart tissue lysates (35 µg/lane). BACE1(arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human brain tissue reacted with BACE1 antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert EIA, WB 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Maus Unkonjugiert CyTOF, FACS, IHC, WB Detection of Human BACE-1 by Western Blot. Western blot shows lysates of human brain (Alzheimer's disease hippocampus) tissue. PVDF Membrane was probed with 2 ug/mL of Mouse Anti-Human/Mouse BACE-1 Ectodomain Monoclonal Antibody. This experiment was conducted under reducing conditions. 100 μg Anmelden zum Anzeigen 8 bis 9 Tage
$328.90
Details
Human Kaninchen Unkonjugiert IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti BACE1/ASP2 Polyclonal Antibody, Unconjugated (ABIN725705) at 1:200 followed by conjugation to the secondary antibody and DAB staining L1 rat brain lysates probed with Anti BACE1/ASP2 Polyclonal Antibody, Unconjugated (ABIN725705) at 1:200 overnight at 4 °C. Followed by conjugation to secondary antibody at 1:3000 for 90 min at 37 °C. Predicted band 51kD. Observed band size:51kD. 100 μL Anmelden zum Anzeigen 3 bis 7 Tage
$318.45
Details

BACE Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

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Am meisten referenzierte anti-beta-Site APP-Cleaving Enzyme 1 Antikörper

  1. Human Polyclonal BACE Primary Antibody für IF (p), IHC (p) - ABIN725705 : Tian, Guo, Wu, Ma, Zhao: Minocycline Alleviates Sevoflurane-Induced Cognitive Impairment in Aged Rats. in Cellular and molecular neurobiology 2015 (PubMed)
    Show all 4 Pubmed References

  2. Human Monoclonal BACE Primary Antibody für CyTOF, FACS - ABIN4900525 : Cheng, He, Lee, Yao, Li, Shen: High activities of BACE1 in brains with mild cognitive impairment. in The American journal of pathology 2013 (PubMed)
    Show all 3 Pubmed References

  3. Human Monoclonal BACE Primary Antibody für CyTOF, FACS - ABIN4900526 : Ahmed, Holler, Webb, Li, Beckett, Murphy: BACE1 and BACE2 enzymatic activities in Alzheimer's disease. in Journal of neurochemistry 2010 (PubMed)
    Show all 3 Pubmed References

  4. Human Monoclonal BACE Primary Antibody für IHC, WB - ABIN4282833 : Prior, Dargusch, Ehren, Chiruta, Schubert: The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice. in Alzheimer's research & therapy 2014 (PubMed)

  5. Cow (Bovine) Polyclonal BACE Primary Antibody für IHC (p) - ABIN2477571 : Rossner, Lange-Dohna, Zeitschel, Perez-Polo: Alzheimer's disease beta-secretase BACE1 is not a neuron-specific enzyme. in Journal of neurochemistry 2005 (PubMed)

  6. Human Polyclonal BACE Primary Antibody für WB - ABIN550289 : Vassar, Bennett, Babu-Khan, Kahn, Mendiaz, Denis, Teplow, Ross, Amarante, Loeloff, Luo, Fisher, Fuller, Edenson, Lile, Jarosinski, Biere, Curran, Burgess, Louis, Collins, Treanor, Rogers, Citron: Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. in Science (New York, N.Y.) 1999 (PubMed)
    Show all 3 Pubmed References

  7. Human Polyclonal BACE Primary Antibody für IHC (p), WB - ABIN392201 : Xie, Guo: PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein. in The Journal of biological chemistry 2005 (PubMed)
    Show all 5 Pubmed References

Weitere Antikörper gegen beta-Site APP-Cleaving Enzyme 1 Interaktionspartner

Human beta-Site APP-Cleaving Enzyme 1 (BACE) Interaktionspartner

  1. Results indicate that SNX4 (zeige SNX4 Antikörper)-mediated regulation of the steady-state levels and trafficking of BACE1, as well as the subsequent increase in BACE1-mediated cleavage, may be relevant to Alzheimer's disease progression.

  2. We discuss how the underlying mechanisms can be conceived and develop scenarios how the regulation of ion conductances by BACE1 might shape electric activity in the intact and diseased brain and heart

  3. Study showed that serum deprivation enhances ADAM10 (zeige ADAM10 Antikörper)/17-mediated cleavage and secretion of enzymatically active BACE1. This could be the result of alterations in the lipid composition of the membrane that lead in disruption of membrane compartmentalization in lipid rafts and non-lipid rafts. At present the significance of BACE1 shedding in the development of Alzheimer's disease is unclear.

  4. Data suggest that trimerization of BACE1 requires transmembrane sequences (TMSs) and cytoplasmic domains, with residues Ala463 and Cys466 buried within trimer interface of the sulfur-rich core of TMSs; BACE1 appears to play role in compartmentalization of intracellular copper by transferring cytosolic copper to intracellular compartments.

  5. SEPT8 (zeige SEPT8 Antikörper) modulates beta-amyloidogenic processing of APP (zeige APP Antikörper) through a mechanism affecting the intracellular sorting and accumulation of BACE1.

  6. the depletion of BIN1 (zeige BIN1 Antikörper) increases cellular BACE1 levels through impaired endosomal trafficking and reduces BACE1 lysosomal degradation, resulting in increased Ab production. Our findings provide a mechanistic role of BIN1 (zeige BIN1 Antikörper) in the pathogenesis of Alzheimer disease (AD), as a novel genetic regulator of BACE1 levels and Ab production

  7. in vitro BACE1-activity assays demonstrate that palmitoylation-dependent dimerization of APP (zeige APP Antikörper) promotes beta-cleavage of APP (zeige APP Antikörper) in lipid-rich detergent resistant cell membranes (DRMs), when compared to total APP (zeige APP Antikörper).

  8. The circular RNA ciRS-7 promotes APP (zeige APP Antikörper) and BACE1 degradation in an NF-kappaB (zeige NFKB1 Antikörper)-dependent manner.

  9. rs638405 in BACE1 was not associated with the risk of Alzheimer's disease (AD), rs638405 decreased the risk of apolipoprotein-E (zeige APOE Antikörper) epsilon4 (APOE4) positive AD patients, rs638405 also decreased the risk of Asian AD patients. Data of meta-analysis suggested rs638405 in BACE1 was a protective factor of AD.

  10. analysis suggests that some familial Alzheimer's disease mutations in APP (zeige APP Antikörper) are amyloidogenic and/or amyloidolytic via selection of alternative BACE1 cleavage sites

Mouse (Murine) beta-Site APP-Cleaving Enzyme 1 (BACE) Interaktionspartner

  1. study demonstrates that SEZ6 and SEZ6L (zeige SEZ6L Antikörper) are physiological BACE1 substrates in the murine brain and suggests that sSEZ6 and sSEZ6L levels in CSF (zeige CSF2 Antikörper) are suitable markers to monitor BACE1 inhibition in mice

  2. Chronic variable stress led to increased Bace1 expression in the hippocampus of young adult mice and the hippocampus, prefrontal cortex and amygdala of aged mice. The increased expression of Bace1 was associated with decreased methylation of several CpGs in the Bace1 promoter region.

  3. Results indicate that SNX4 (zeige SNX4 Antikörper)-mediated regulation of the steady-state levels and trafficking of BACE1, as well as the subsequent increase in BACE1-mediated cleavage, may be relevant to Alzheimer's disease progression.

  4. In conclusion, glucocorticoid couples mGR (zeige GRHL1 Antikörper) with Galphas (zeige GNAS Antikörper) and triggers cAMP-PKA-CREB (zeige CREB1 Antikörper) axis dependent on the lipid raft to stimulate BACE1 upregulation and Abeta (zeige APP Antikörper) generation.SIGNIFICANCE STATEMENT Patients with Alzheimer's disease (AD) have been growing sharply and stress is considered as the major environment factor of AD.

  5. study supports the hypothesis that Abeta (zeige APP Antikörper) induces microtubule disruption in presynaptic dystrophic neurites that surround plaques, thus impairing axonal transport and leading to accumulation of BACE1 and exacerbation of amyloid pathology in Alzheimer's disease

  6. Here, we demonstrate that Snapin (zeige SNAPIN Antikörper)-mediated retrograde transport plays a critical role in removing BACE1 from presynaptic terminals toward the soma, thus reducing synaptic Abeta (zeige APP Antikörper) production. Adeno (zeige ADORA2A Antikörper)-associated virus-mediated Snapin (zeige SNAPIN Antikörper) overexpression in the hippocampus of mutant hAPP mice significantly decreases synaptic Abeta (zeige APP Antikörper) levels, attenuates synapse loss, and thus rescues cognitive deficits. Our study uncovers a new pathway...

  7. beta-site APP cleaving enzyme 1 (BACE1) is essential for amyloid beta protein production. We discovered that A673V mutation shifted the BACE1 cleavage site from the Glu (zeige GCG Antikörper)(11) to the Asp(1 (zeige BACE2 Antikörper)) site, resulting in much higher C99 level and C99/C89 ratio.

  8. SEPT8 (zeige SEPT8 Antikörper) modulates beta-amyloidogenic processing of APP (zeige APP Antikörper) through a mechanism affecting the intracellular sorting and accumulation of BACE1.

  9. the depletion of BIN1 (zeige BIN1 Antikörper) increases cellular BACE1 levels through impaired endosomal trafficking and reduces BACE1 lysosomal degradation, resulting in increased Ab production. Our findings provide a mechanistic role of BIN1 (zeige BIN1 Antikörper) in the pathogenesis of Alzheimer disease (AD), as a novel genetic regulator of BACE1 levels and Ab production

  10. In an Alzheimer's disease mouse model we show that BACE-1 is upregulated at the blood-brain barrier compared to healthy controls.

Zebrafish beta-Site APP-Cleaving Enzyme 1 (BACE) Interaktionspartner

  1. bace1 mutants display hypomyelination in the peripheral nervous system and supernumerary neuromasts while in bace2 (zeige BACE2 Antikörper) mutants the shape and migration of melanocytes is affected.

beta-Site APP-Cleaving Enzyme 1 (BACE) Antigen-Profil

Protein Überblick

Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene.

Genbezeichner und Symbole assoziert mit BACE

  • beta-secretase 1 (BACE1) Antikörper
  • beta-site APP cleaving enzyme 1 (Bace1) Antikörper
  • beta-secretase 1 (Bace1) Antikörper
  • beta-site APP-cleaving enzyme 1 (bace1) Antikörper
  • beta-site APP-cleaving enzyme 2 L homeolog (bace2.L) Antikörper
  • beta-site APP-cleaving enzyme 2 S homeolog (bace2.S) Antikörper
  • beta-site APP-cleaving enzyme 2 (bace2) Antikörper
  • beta-site APP-cleaving enzyme 2 (BACE2) Antikörper
  • ASP2 Antikörper
  • Bace Antikörper
  • BACE1 Antikörper
  • BACE2 Antikörper
  • C76936 Antikörper
  • HSPC104 Antikörper
  • MGC68482 Antikörper
  • MGC68881 Antikörper
  • MGC145931 Antikörper
  • zgc:77409 Antikörper

Bezeichner auf Proteinebene für BACE

APP beta-secretase , asp 2 , aspartyl protease 2 , beta-secretase 1 , beta-secretase 1 precursor variant 1 , beta-site APP cleaving enzyme 1 , beta-site amyloid beta A4 precursor protein-cleaving enzyme , memapsin-2 , membrane-associated aspartic protease 2 , transmembrane aspartic proteinase Asp2 , ASP2 , beta-site amyloid precursor protein cleaving enzyme 1 , beta-site APP cleaving enzyme , beta secretase 1 , beta-secretase 1 isoform A preproprotein , beta-secretase 1 isoform B preproprotein , beta-secretase 1 isoform C preproprotein , beta-site APP-cleaving enzyme 1 , beta-secretase 1-like , beta-site APP-cleaving enzyme 2 , beta-secretase 2-like

GENE ID SPEZIES
23621 Homo sapiens
23821 Mus musculus
29392 Rattus norvegicus
419768 Gallus gallus
489390 Canis lupus familiaris
614333 Bos taurus
697694 Macaca mulatta
779940 Xenopus (Silurana) tropicalis
100071137 Equus caballus
100343442 Oryctolagus cuniculus
100459804 Pongo abelii
380307 Xenopus laevis
398806 Xenopus laevis
100216145 Xenopus (Silurana) tropicalis
100224177 Taeniopygia guttata
451573 Pan troglodytes
100025518 Monodelphis domestica
403005 Danio rerio
100135485 Cavia porcellus
100016587 Monodelphis domestica
100406072 Callithrix jacchus
747819 Pan troglodytes
100602656 Nomascus leucogenys
100511707 Sus scrofa
101119667 Ovis aries
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