Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Zusätzlich bieten wir Ihnen beta-Site APP-Cleaving Enzyme 1 Kits (59) und beta-Site APP-Cleaving Enzyme 1 Proteine (32) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 270 products:
Human Polyclonal BACE Primary Antibody für IF (p), IHC (p) - ABIN725705
Tian, Guo, Wu, Ma, Zhao: Minocycline Alleviates Sevoflurane-Induced Cognitive Impairment in Aged Rats. in Cellular and molecular neurobiology 2015
Show all 4 Pubmed References
Human Monoclonal BACE Primary Antibody für CyTOF, FACS - ABIN4900525
Cheng, He, Lee, Yao, Li, Shen: High activities of BACE1 in brains with mild cognitive impairment. in The American journal of pathology 2013
Show all 3 Pubmed References
Human Monoclonal BACE Primary Antibody für CyTOF, FACS - ABIN4900526
Ahmed, Holler, Webb, Li, Beckett, Murphy: BACE1 and BACE2 enzymatic activities in Alzheimer's disease. in Journal of neurochemistry 2010
Show all 3 Pubmed References
Human Monoclonal BACE Primary Antibody für IHC, WB - ABIN4282833
Prior, Dargusch, Ehren, Chiruta, Schubert: The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice. in Alzheimer's research & therapy 2014
Cow (Bovine) Polyclonal BACE Primary Antibody für IHC (p) - ABIN2477571
Rossner, Lange-Dohna, Zeitschel, Perez-Polo: Alzheimer's disease beta-secretase BACE1 is not a neuron-specific enzyme. in Journal of neurochemistry 2005
Human Polyclonal BACE Primary Antibody für WB - ABIN550289
Vassar, Bennett, Babu-Khan, Kahn, Mendiaz, Denis, Teplow, Ross, Amarante, Loeloff, Luo, Fisher, Fuller, Edenson, Lile, Jarosinski, Biere, Curran, Burgess, Louis, Collins, Treanor, Rogers, Citron: Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. in Science (New York, N.Y.) 1999
Show all 3 Pubmed References
Human Polyclonal BACE Primary Antibody für IHC (p), WB - ABIN392201
Xie, Guo: PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein. in The Journal of biological chemistry 2005
Show all 5 Pubmed References
Results indicate that SNX4 (zeige SNX4 Antikörper)-mediated regulation of the steady-state levels and trafficking of BACE1, as well as the subsequent increase in BACE1-mediated cleavage, may be relevant to Alzheimer's disease progression.
We discuss how the underlying mechanisms can be conceived and develop scenarios how the regulation of ion conductances by BACE1 might shape electric activity in the intact and diseased brain and heart
Study showed that serum deprivation enhances ADAM10 (zeige ADAM10 Antikörper)/17-mediated cleavage and secretion of enzymatically active BACE1. This could be the result of alterations in the lipid composition of the membrane that lead in disruption of membrane compartmentalization in lipid rafts and non-lipid rafts. At present the significance of BACE1 shedding in the development of Alzheimer's disease is unclear.
Data suggest that trimerization of BACE1 requires transmembrane sequences (TMSs) and cytoplasmic domains, with residues Ala463 and Cys466 buried within trimer interface of the sulfur-rich core of TMSs; BACE1 appears to play role in compartmentalization of intracellular copper by transferring cytosolic copper to intracellular compartments.
SEPT8 (zeige SEPT8 Antikörper) modulates beta-amyloidogenic processing of APP (zeige APP Antikörper) through a mechanism affecting the intracellular sorting and accumulation of BACE1.
the depletion of BIN1 (zeige BIN1 Antikörper) increases cellular BACE1 levels through impaired endosomal trafficking and reduces BACE1 lysosomal degradation, resulting in increased Ab production. Our findings provide a mechanistic role of BIN1 (zeige BIN1 Antikörper) in the pathogenesis of Alzheimer disease (AD), as a novel genetic regulator of BACE1 levels and Ab production
in vitro BACE1-activity assays demonstrate that palmitoylation-dependent dimerization of APP (zeige APP Antikörper) promotes beta-cleavage of APP (zeige APP Antikörper) in lipid-rich detergent resistant cell membranes (DRMs), when compared to total APP (zeige APP Antikörper).
The circular RNA ciRS-7 promotes APP (zeige APP Antikörper) and BACE1 degradation in an NF-kappaB (zeige NFKB1 Antikörper)-dependent manner.
rs638405 in BACE1 was not associated with the risk of Alzheimer's disease (AD), rs638405 decreased the risk of apolipoprotein-E (zeige APOE Antikörper) epsilon4 (APOE4) positive AD patients, rs638405 also decreased the risk of Asian AD patients. Data of meta-analysis suggested rs638405 in BACE1 was a protective factor of AD.
analysis suggests that some familial Alzheimer's disease mutations in APP (zeige APP Antikörper) are amyloidogenic and/or amyloidolytic via selection of alternative BACE1 cleavage sites
study demonstrates that SEZ6 and SEZ6L (zeige SEZ6L Antikörper) are physiological BACE1 substrates in the murine brain and suggests that sSEZ6 and sSEZ6L levels in CSF (zeige CSF2 Antikörper) are suitable markers to monitor BACE1 inhibition in mice
Chronic variable stress led to increased Bace1 expression in the hippocampus of young adult mice and the hippocampus, prefrontal cortex and amygdala of aged mice. The increased expression of Bace1 was associated with decreased methylation of several CpGs in the Bace1 promoter region.
In conclusion, glucocorticoid couples mGR (zeige GRHL1 Antikörper) with Galphas (zeige GNAS Antikörper) and triggers cAMP-PKA-CREB (zeige CREB1 Antikörper) axis dependent on the lipid raft to stimulate BACE1 upregulation and Abeta (zeige APP Antikörper) generation.SIGNIFICANCE STATEMENT Patients with Alzheimer's disease (AD) have been growing sharply and stress is considered as the major environment factor of AD.
study supports the hypothesis that Abeta (zeige APP Antikörper) induces microtubule disruption in presynaptic dystrophic neurites that surround plaques, thus impairing axonal transport and leading to accumulation of BACE1 and exacerbation of amyloid pathology in Alzheimer's disease
Here, we demonstrate that Snapin (zeige SNAPIN Antikörper)-mediated retrograde transport plays a critical role in removing BACE1 from presynaptic terminals toward the soma, thus reducing synaptic Abeta (zeige APP Antikörper) production. Adeno (zeige ADORA2A Antikörper)-associated virus-mediated Snapin (zeige SNAPIN Antikörper) overexpression in the hippocampus of mutant hAPP mice significantly decreases synaptic Abeta (zeige APP Antikörper) levels, attenuates synapse loss, and thus rescues cognitive deficits. Our study uncovers a new pathway...
beta-site APP cleaving enzyme 1 (BACE1) is essential for amyloid beta protein production. We discovered that A673V mutation shifted the BACE1 cleavage site from the Glu (zeige GCG Antikörper)(11) to the Asp(1 (zeige BACE2 Antikörper)) site, resulting in much higher C99 level and C99/C89 ratio.
In an Alzheimer's disease mouse model we show that BACE-1 is upregulated at the blood-brain barrier compared to healthy controls.
bace1 mutants display hypomyelination in the peripheral nervous system and supernumerary neuromasts while in bace2 (zeige BACE2 Antikörper) mutants the shape and migration of melanocytes is affected.
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene.
, asp 2
, aspartyl protease 2
, beta-secretase 1
, beta-secretase 1 precursor variant 1
, beta-site APP cleaving enzyme 1
, beta-site amyloid beta A4 precursor protein-cleaving enzyme
, membrane-associated aspartic protease 2
, transmembrane aspartic proteinase Asp2
, beta-site amyloid precursor protein cleaving enzyme 1
, beta-site APP cleaving enzyme
, beta secretase 1
, beta-secretase 1 isoform A preproprotein
, beta-secretase 1 isoform B preproprotein
, beta-secretase 1 isoform C preproprotein
, beta-site APP-cleaving enzyme 1
, beta-secretase 1-like
, beta-site APP-cleaving enzyme 2
, beta-secretase 2-like