anthrax Toxin Receptor 1 Proteine (ANTXR1)

ANTXR1 encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. Zusätzlich bieten wir Ihnen anthrax Toxin Receptor 1 Antikörper (176) und anthrax Toxin Receptor 1 Kits (4) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
ANTXR1 84168 Q9H6X2
ANTXR1 69538 Q9CZ52
ANTXR1 362393 Q0PMD2
Direkt bei antikoerper-online bestellen
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Online bestellen
  • orders@antikoerper-online.de

Top anthrax Toxin Receptor 1 Proteine auf antikoerper-online.de

Showing 8 out of 14 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
$4,244.78
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$5,442.50
Details
Human Cells Human Fc Tag 50 μg Anmelden zum Anzeigen 20 bis 21 Tage
$382.80
Details
Mammalian Cells Human His tag   50 μg Anmelden zum Anzeigen 4 Days
$404.25
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 10 bis 12 Tage
$785.40
Details
Human Human His tag   10 μg Anmelden zum Anzeigen 15 bis 16 Tage
$225.00
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$405.71
Details
Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,777.50
Details

ANTXR1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , , ,
, , , ,
Mouse (Murine)
,
Rat (Rattus)

Weitere Proteine zu anthrax Toxin Receptor 1 (ANTXR1) Interaktionspartnern

Human anthrax Toxin Receptor 1 (ANTXR1) Interaktionspartner

  1. These studies identify ANTXR1, a class of receptor that is shared by a mammalian virus and a bacterial toxin, as the cellular receptor for Seneca Valley virus.

  2. Findings suggest that down-regulation of tumor endothelial marker 8 play an important role in the inhibition of tumorigenesis and development of osteosarcoma.

  3. TEM8 may be differentially expressed between wound types and loss of this molecule impacts HaCaT growth and migration, potentially implicating this molecule as a factor involved in successful progression of wound healing.

  4. In the absence of any N-linked glycans, TEM8 fails to fold correctly and is recognized by the ER quality control machinery.

  5. These studies expand the allelic spectrum in this rare condition and potentially provide insight into the role of ANTXR1 in the regulation of the extracellular matrix.

  6. ANTXR2 (zeige ANTXR2 Proteine) is expressed by human uterine smooth muscle cell and appears important for normal human uterine smooth muscle cell viability, migration and contractility.

  7. High ANTXR1 accelerates breast tumor growth and lung metastasis.

  8. There is an attenuation of ANTXR1 expression post-infection which may be a protective mechanism that has evolved to prevent reinfection.

  9. Mutations affecting ANTXR1 function are responsible for GAPO syndrome's characteristic generalized defect in extracellular-matrix homeostasis.

  10. An acidic region in the cytosolic tail of ANTXR1 decreases actin association, sending a signal that prevents binding of ANTXR1 to the protective antigen and providing evidence that cytoskeletal dynamics regulate ANTXR1 function.

Mouse (Murine) anthrax Toxin Receptor 1 (ANTXR1) Interaktionspartner

  1. Anthrax Toxin Protective Antigen Variants That Selectively Utilize either the CMG2 (zeige ANTXR2 Proteine) or TEM8 Receptors for Cellular Uptake and Tumor Targeting.

  2. An essential physiologic role for Antxr1 in arteriogenesis and peripheral artery disease.

  3. Data demonstrate that TEM8 is an essential regulator of connective tissue homeostasis. it controls synthesis of major matrix components in both endothelial and fibroblastic cells and regulates signaling pathways and matrix degradation.

  4. These results strongly suggest that TEM8 is the only minor anthrax toxin receptor mediating direct lethality in vivo and that other proteins implicated as receptors do not play this role.

  5. This is the first demonstration that the ATR/TEM8 protein is highly expressed in epithelial cells, suggesting that the ATR/TEM8 expression pattern is highly relevant for understanding the pathogenesis of anthrax infection.

  6. The mRNA transcripts of both receptors, ANTXR1 and ANTXR2 (zeige ANTXR2 Proteine) were detected in J774A.1 cells and mouse tissues suggesting that anthrax edema toxin and B. anthracis Sterne spore are involved in the ANTXR mRNA regulation in host cells.

  7. Data show that the lethality of anthrax toxin for mice is mostly mediated by CMG2 (zeige ANTXR2 Proteine) and that TEM8 plays only a minor role.

  8. Host-derived TEM8 promotes the growth of certain tumors.

anthrax Toxin Receptor 1 (ANTXR1) Protein Überblick

Protein Überblick

This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described.

Genbezeichner und Symbole assoziert mit ANTXR1

  • anthrax toxin receptor 1 (ANTXR1)
  • anthrax toxin receptor 1 (Antxr1)
  • 2310008J16Rik Protein
  • 2810405N18Rik Protein
  • Antrx1 Protein
  • ANTXR1 Protein
  • ATR Protein
  • Tem8 Protein

Bezeichner auf Proteinebene für ANTXR1

anthrax toxin receptor 1 , tumor endothelial marker 8 , anthrax toxin receptor 1-like , 2310008J16Rik , 2810405N18Rik

GENE ID SPEZIES
470393 Pan troglodytes
612601 Canis lupus familiaris
100061334 Equus caballus
100357637 Oryctolagus cuniculus
100410030 Callithrix jacchus
100425392 Macaca mulatta
100513853 Sus scrofa
100598321 Nomascus leucogenys
84168 Homo sapiens
69538 Mus musculus
362393 Rattus norvegicus
616010 Bos taurus
428199 Gallus gallus
Ausgewählte Anbieter für anthrax Toxin Receptor 1 Proteine (ANTXR1)
Haben Sie etwas anderes gesucht?