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acts as a transcriptional repressor\; may play a role in osteoclastogenesis [RGD, Feb 2006].. Zusätzlich bieten wir Ihnen ZBTB7A Antikörper (112) und ZBTB7A Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
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Our study uncovers the loss-of-function mutation in ZBTB7A as a novel mechanism causing elevated glycolysis in human cancer, which carries important therapeutic implication.
Mutation in ZBTB7A is associated with core-binding factor (zeige CBFB ELISA Kits) acute myeloid leukemia (zeige BCL11A ELISA Kits).
Zbtb7a knockdown by siRNA suppressed cell proliferation and i (zeige MLXIP ELISA Kits)nduced G1 cell cycle arrest and apoptosis (zeige MLXIP ELISA Kits) in lung cancer cells. Furthermore, miR-125a expression showed a negative correlation with Zbtb7a expression in non-small cell lung cancer tissues.
Data suggest that microRNA miR (zeige MLXIP ELISA Kits)-520e directly targets to the 3'-untranslated region (3'-UTR (zeige UTS2R ELISA Kits)) of zinc finger and BTB domain containing 7A protein (Zbtb7a).
CCAT2 promotes tumorigenesis by over-expression of Pokemon.
High FBI-1 expression is associated with hepatocellular carcinoma.
there is an auto-regulatory circuit consisting of miR (zeige MLXIP ELISA Kits)-125 and Pokemon, which promotes the progression of HCC (zeige FAM126A ELISA Kits) and may be a promising therapeutic target in clinical HCC (zeige FAM126A ELISA Kits) treatment
Pokemon was found to enhance the migration and invasion of hepatocellular carcinoma by increasing MEF2D (zeige MEF2D ELISA Kits) expression
Pokemon was significantly downregulated in OSCC.
ZBTB7A directly binds to the promoter and transcriptionally represses the expression of MCAM (zeige MCAM ELISA Kits), establishing ZBTB7A as a bona fide transcriptional repressor of MCAM (zeige MCAM ELISA Kits)
this study shows that Thpok (zeige ZBTB7B ELISA Kits) and LRF are redundantly required to maintain the size and functions of the postthymic Treg pool
This study identified Zbtb7a as a novel direct target for miR (zeige MLXIP ELISA Kits)-125a by gene expression profiling in miR (zeige MLXIP ELISA Kits)-125a knockout mice combined with bioinformatics target prediction, and elucidated the role of Zbtb7a in oncogenesis.
This study demonstrated an unexpected transcription-independent function for LRF in the classical non-homologous end joining pathway of double-strand break repair.
LRF short hairpin RNA suppressed the expression of LRF protein in a glioma cell line compared to the negative control vector-transfected glioma cells. LRF knockdown also reduced cell viability and enhanced cisplatin-induced apoptosis in glioma cells.
Data indicate that transcription factors Thpok (zeige ZBTB7B ELISA Kits) and LRF redundantly maintain CD4 (zeige CD4 ELISA Kits)+ lineage integrity.
Findings demonstrate that Pokemon suppresses Sprouty1 expression through a miR (zeige MLXIP ELISA Kits)-21-mediated mechanism, affecting the growth and proliferation of liver cancer cells.
Data show that Notch1 (zeige NOTCH1 ELISA Kits)/Dll4 (zeige DLL4 ELISA Kits)-mediated T-cell instructive signals to long-term HSCs (LT-HSCs) are suppressed by Lrf expression in the bone marrow microenvironment.
These results support a critical role for LRF in transcriptional control of differentiation in oligodendrocyte lineage cells during developmental myelination in the CNS.
T cells lacking Thpok (zeige ZBTB7B ELISA Kits), which only displayed LRF-dependent functions, contributed to multiple effector responses, both in vitro and in vivo, with the notable exception of Th2 cell responses that control extracellular parasites
study shows that LRF plays stage-specific distinct roles in osteoclast differentiation, exemplifying the delicate transcriptional regulation at work in lineage commitment
acts as a transcriptional repressor\; may play a role in osteoclastogenesis
zinc finger and BTB domain containing 7A
, similar to zinc finger and BTB domain containing 36
, HIV-1 1st-binding protein 1
, HIV-1 inducer of short transcripts binding protein
, POK erythroid myeloid ontogenic factor
, POZ and Krueppel erythroid myeloid ontogenic factor
, TTF-I-interacting peptide 21
, factor binding IST protein 1
, factor that binds to inducer of short transcripts protein 1
, leukemia/lymphoma-related factor
, lymphoma related factor
, zinc finger and BTB domain containing 7A, HIV-1 inducer of short transcripts binding protein
, zinc finger and BTB domain-containing protein 7A
, zinc finger protein 857A
, leukemia/lymphoma related factor
, osteoclast-derived zinc finger protein
, leukemia/lymphoma related factor cLRF