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ZIC1 encodes a member of the ZIC family of C2H2-type zinc finger proteins. Zusätzlich bieten wir Ihnen ZIC1 Antikörper (78) und viele weitere Produktgruppen zu diesem Protein an.
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down-regulated expression of ZIC1 contributed to the inhibition of cell proliferation, and inhibited the growth of tumor
our results suggest that the Zic1 promoter methylation rate in plasma-derived DNA is of great significance for the early screening of gastric cancer and monitoring of tumorigenesis
Gain-of-Function Mutations in ZIC1 Are Associated with Coronal Craniosynostosis and Learning Disability.
ZIC1 might play a role in the development of Ovarian Cancer, and may be a therapeutic target in OC.
aberrant methylation is an important mechanism for ZIC1 inactivation in Hepatocellular carcinoma (HCC (zeige FAM126A Proteine)).
ZIC1 is frequently inactivated by promoter hypermethyaltion and functions as a tumor suppressor in thyroid cancer through modulating PI3K (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine) and MAPK (zeige MAPK1 Proteine) signaling pathways and transcription factor FOXO3a (zeige FOXO3 Proteine).
Loss of ZIC1 expression is associated with malignant pleural mesothelioma.
Methylation of ZIC1, a putative tumor suppressor, may be a novel determinant of ovarian cancer outcome
Zic transcription factors function in patterning hindbrain motor neurons through their regulation of embryonic retinoic acid signaling
Overexpression of ZIC1 results in inactivation of Shh (zeige SHH Proteine), PI(3 (zeige PI3 Proteine))K and MAPK (zeige MAPK1 Proteine) signaling pathways, as well as regulation of multiple downstream targets which are essential for the development and progression of gastric cancer.
Zic1, expressed at the anterior neural plate, is necessary and sufficient to promote placode fate.
Pax3 (zeige PAX3 Proteine) and Zic1 trigger the early neural crest gene regulatory network by the direct activation of multiple key neural crest specifiers.
Pax3 (zeige PAX3 Proteine) and Zic1 drive induction and differentiation of multipotent, migratory, and functional neural crest in Xenopus embryos.
XMeis3 (zeige MEIS3 Proteine) protein knock down also causes a loss of primary neuron and neural crest cell lineages, without altering expression of Zic, Sox (zeige PIPOX Proteine) or Pax3 (zeige PAX3 Proteine) genes.
Co-activation of Pax3 (zeige PAX3 Proteine) and Zic1, in concert with Wnt (zeige WNT2 Proteine), plays a decisive role for early neural crest determination in the correct place of the Xenopus ectoderm.
These data suggest that interruption of BMP signaling facilitates neural determination via a complex mechanism, involving multiple regulatory factors that cooperate to control zic1 expression
Zic1 directly upregulated the Xfeb gene during early neural development.
Zic1 is an activator of Wnt (zeige WNT2 Proteine) signaling.
Data show that Pax3 (zeige PAX3 Proteine) and Zic1 are necessary and sufficient to promote hatching gland and preplacodal fates, respectively, and that their combined activity is essential to specify the neural crest.
aqp-3b was upregulated by Zic1
Zic1 and Zic2 (zeige ZIC2 Proteine) proteins are essential to control the balance between two defined neuron types in the postnatal forebrain.
Brn2 (zeige POU3F2 Proteine)-Zic1 axis is essential to specify neural fate in retinoic-acid-treated embryonic stem cells.
Zic1 and Zic2 (zeige ZIC2 Proteine) are required for coordinating mature neuronal gene expression patterns.
Association with DNA-bound Pax3 (zeige PAX3 Proteine) strengthens the ability of both Zic1 and Gli2 to transactivate Myf5 (zeige MYF5 Proteine) in the epaxial somite.
Zic1 and Zic4 (zeige ZIC4 Proteine) have both Shh (zeige SHH Proteine)-dependent and -independent roles during cerebellar development and multiple developmental disruptions underlie Zic1/4-related Dandy-walker malformation.
Myf5 (zeige MYF5 Proteine) activation in newly forming somites is delayed in Zic2 (zeige ZIC2 Proteine) mutant embryos until the time of Zic1 activation, and both Zic2 (zeige ZIC2 Proteine) and Myf5 (zeige MYF5 Proteine) require noggin (zeige NOG Proteine) for their activation
Zic1, a neural developmental transcription factor, plays an important role in shear flow mechanotransduction in osteocytes.
findings suggest that Zic1 controls the expansion of neuronal precursors by inhibiting the progression of neuronal differentiation
The functions of Zic1 and Zic3 (zeige ZIC3 Proteine) may be essential to increasing neural cell numbers regionally in the medial telencephalon and to proper mediolateral patterning of the telencephalon.
This study reveal a new role for Zic1 as a cell-autonomous regulator of key aspects of nucleus formation and axon pathway choice in the ventral brain stem.
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene.
Zic family member 1 (odd-paired homolog, Drosophila)
, Zinc finger protein of the cerebellum 1
, zinc finger protein 201
, zinc finger protein ZIC 1
, zic protein member 1
, zinc finger protein of the cerebellum 1
, ZIC-related protein 1
, Zic family member 1 (odd-paired homolog)
, odd-paired homolog