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ZNF750 encodes a protein with a nuclear localization site and a C2H2 zinc finger domain. Zusätzlich bieten wir Ihnen Zinc Finger Protein 750 Antikörper (26) und viele weitere Produktgruppen zu diesem Protein an.
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Human ZNF750 Protein expressed in Escherichia coli (E. coli) - ABIN2736118
Boxer, Barajas, Tao, Zhang, Khavari: ZNF750 interacts with KLF4 and RCOR1, KDM1A, and CTBP1/2 chromatin regulators to repress epidermal progenitor genes and induce differentiation genes. in Genes & development 2014
BENI expression is regulated by activin-like signaling, and that this regulation is crucial for Xbra expression and convergent extension during gastrulation.
Suggest no connection of ZNF750 variants with psoriasis or its subphenotypes.
ZNF750 thus controls differentiation in concert with RCOR1 (zeige RCOR1 Proteine) and CTBP1 (zeige CTBP1 Proteine)/2 by acting with either KDM1A (zeige KDM1A Proteine) to repress progenitor genes or KLF4 (zeige KLF4 Proteine) to induce differentiation genes.
ZNF750 was specifically expressed in the epidermal suprabasal layers and its expression was augmented during differentiation, both in human skin and in-vitro, peaking in the granular layer.
ZNF750 directly links a tissue-specifying factor, p63 (zeige RPE65 Proteine), to an effector of terminal differentiation, KLF4 (zeige KLF4 Proteine).
Two haplotypes of ZNF750 and rare 5' regulatory variants of ZNF750 were found to be associated with psoriasis.
ZNF750 mutations could contribute to psoriasis susceptibility.
This gene encodes a protein with a nuclear localization site and a C2H2 zinc finger domain. Mutations in this gene have been associated with seborrhea-like dermatitis with psoriasiform elements.
, zinc finger protein 750
, superficial protein 1
, Protein ZNF750
, brachyury expression nuclear inhibitor