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May be involved in transcriptional regulation..
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ZNF424 protein may act as a transcriptional repressor that suppresses NFAT (zeige NFATC1 Proteine) and p21 (zeige CDKN1A Proteine) pathway to mediate cellular functions.
another function of ZFP57 in early embryogenesis is to repress cis (zeige CISH Proteine)-acting regulatory elements whose activity is not yet required.
Data show that ZFP57 binding is affected by single nucleotide polymorphism (SNPs) and closely associated TGCCGC motif sequences that are present at the target sites.
Within established mouse imprinted clusters, ZFP57 specifically binds known or predicted imprinting control region elements, but does not interact with secondary somatically differentially methylated regions (DMRs) or germline DMRs that are not imprinting controlling.
ZFP57 may modulate NOTCH (zeige NOTCH1 Proteine) signaling during cardiac development.
Taken together, our results suggest that Nanog positively regulates Zfp57 expression in multiple types of cells.
Mouse and human ZFP57 are orthologs despite relatively low sequence identity.
Data suggest that Glu182 in the DNA binding site in zinc finger motif of Zfp57 plays important role in binding specificity and affinity for 5-carboxylcytosine and other cytosine analogs.
the structure of the DNA-binding domain of Zfp57, consisting of two adjacent zinc fingers, in complex with fully methylated DNA
ZFP57 may recruit DNA methyltransferases to its target regions to maintain DNA methylation (zeige HELLS Proteine) imprint, and this interaction is likely facilitated by KAP1/TRIM28/TIF1beta (zeige TRIM28 Proteine).
In embryonic stem cells, ZFP57/KAP1 (zeige TRIM28 Proteine) recognize a methylated hexanucleotide to affect chromatin and DNA methylation (zeige HELLS Proteine) of imprinting control regions.
May be involved in transcriptional regulation.
zinc finger protein 424