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Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Zusätzlich bieten wir Ihnen ZFPM1 Antikörper (30) und viele weitere Produktgruppen zu diesem Protein an.
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Forced FOG1 protein expression in K562 erythroleukemia cells induced the expression of SLC4A1 (zeige SLC4A1 Proteine) protein, but repressed that of transcription factor PU.1.
GAB2 (zeige GAB2 Proteine), GSPT1 (zeige GSPT1 Proteine), TFDP2 (zeige TFDP2 Proteine) and ZFPM1 are four new susceptibility loci for testicular germ cell tumor.
FOG1 is a member of the PR domain containing, zinc finger protein family of transcriptional regulators.
Our results reveal that the protein structure does not affect ligand binding, and the top three TCM candidates Bittersweet alkaloid II, Eicosandioic acid, and Perivine might resolve the instability of the RbAp48 (zeige RBBP4 Proteine)-FOG1 complex
FOG1, FOG2 and GATA-6 (zeige GATA6 Proteine) modulate the transcriptional up-regulation of HAMP (zeige HAMP Proteine) in hepatocytes during inflammation.
ZFPM1 that facilitates human Th1 (zeige TH1L Proteine) differentiation via the downregulation of IL-4 (zeige IL4 Proteine) is a potential target for the treatment of allergic diseases.
Anagrelide suppresses megakaryocytopoiesis by reducing the expression levels of GATA-1 (zeige GATA1 Proteine) and FOG-1 via a PDEIII-independent mechanism that is differentiation context-specific and does not involve inhibition of MPL (zeige MPL Proteine)-mediated early signal transduction events
The FOG-1 peptide contacts a negatively charged binding pocket on top of the RbAp48 beta-propeller that is distinct from the binding surface used by RpAp48 to contact histone H4
X-linked thrombocytopenia with thalassemia from a mutation in the amino finger of GATA-1 (zeige GATA1 Proteine) affects DNA binding but does not affect FOG-1 interaction.(FOG1, cofactor of GATA1 (zeige GATA1 Proteine))
Erythroid and megakaryocytic lineage differentiation and maturation are regulated via cooperation between transcription factor GATA1 (zeige GATA1 Proteine) and its essential cofactor FOG1. It depends on the binding of FOG1 to the N-terminalfinger of GATA1 (zeige GATA1 Proteine).
the role of FOG-1 in B lymphocytes
FOG-1 is required for the formation of all committed Mk- and E-lineage progenitors. It mediates transcriptional megakaryocyte/erythrocyte programming of HSCs as well as their subsequent Mk/E-lineage commitment.
Disruption of the GATA1 (zeige GATA1 Proteine)/FOG1/NuRD transcriptional system results in a complex, pleiotropic platelet defect beyond gray platelet syndrome-like macrothrombocytopenia.
These results implicate FOG1 and 2 and CTBPs as partners of GATA proteins in the control of adipocyte proliferation and differentiation.
role of the hematopoietic transcription factor GATA-1, its cofactor FOG-1, and the associated chromatin remodeling complex NuRD in the developmental silencing of HBG1 and HBG2 gene expression
The continuous presence of GATA1 (zeige GATA1 Proteine), FOG1, and NuRD is required to maintain lineage fidelity throughout megakaryocyte-erythroid ontogeny.
Data demonstrate that sumoylation of GATA-1 (zeige GATA1 Proteine) K137 promotes transcriptional activation only at target genes requiring the coregulator Friend of GATA-1 (FOG-1).
Gene expression analysis in primary mutant erythroid cells and megakaryocytes revealed an essential function for NuRD during both the repression and activation of select Gata-1 (zeige GATA1 Proteine)/Fog1 target genes.
Homozygous Fog1(R3K5A) mice were found to have splenomegaly, extramedullary erythropoiesis, granulocytosis and thrombocytopaenia secondary to a block in megakaryocyte maturation.
a requirement for FOG and its interaction with NuRD during primitive erythropoiesis
we identified 2 cis (zeige CISH Proteine)-regulatory elements that control the tissue-specific gene expression of FOG-1.
Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2.
, friend of GATA 1
, friend of GATA protein 1
, friend of GATA-1
, zinc finger protein 89A
, zinc finger protein ZFPM1
, zinc finger protein, multitype 1
, Friend of GATA 1
, Friend of GATA-1
, Friend of GATA protein 1
, zinc finger protein FOG
, friend of Gata1
, friend-of-GATA 1
, zinc finger protein FOG1
, zinc finger protein 469
, zinc finger protein ZFPM1-like