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ZFYVE26 encodes a protein which contains a FYVE zinc finger binding domain. Zusätzlich bieten wir Ihnen Zinc Finger, FYVE Domain Containing 26 Antikörper (14) und viele weitere Produktgruppen zu diesem Protein an.
we describe an uncharacterized cellular mechanism for Suf/Spastizin activity during secretion, which raises the possibility of novel therapeutic avenues for HSP research.
Our protocol showed high specificity and sensitivity for homozygosity detection and facilitated the identification of novel mutations in GAN (zeige GAN ELISA Kits), GBA2 (zeige GBA2 ELISA Kits), and ZFYVE26 in four families affected by hereditary spastic paraplegia or Charcot-Marie-Tooth disease
spastizin and spatacsin (zeige SPG11 ELISA Kits) were essential components for the initiation of lysosomal tubulation. Together, these results link dysfunction of the autophagy/lysosomal biogenesis machinery to neurodegeneration.
ZFYVE26 is a key determinant of autophagosome maturation
spg15 should be search for in the case of juvenile levodopa reponsive parkinsonism
We propose AP-5 (zeige AP5B1 ELISA Kits), SPG15, SPG11 (zeige SPG11 ELISA Kits) form a coat-like complex, with AP-5 (zeige AP5B1 ELISA Kits) involved in protein sorting, SPG15 facilitating docking of the coat onto membranes by interacting with PI3P via its FYVE domain, and SPG11 (zeige SPG11 ELISA Kits) (possibly together with SPG15) forming a scaffold.
spastizin interacts with the autophagy related Beclin 1-UVRAG-Rubicon multiprotein complex and is required for autophagosome maturation.
SPG15 was strongly expressed in cortical and spinal motor neurons and in embryos. It partially co-localized with multiple organelles, particularly with protein-trafficking vesicles, endoplasmic reticulum, microtubules and the mitochondria surface.
Findings suggest a positive feedback loop for recruitment of FYVE-CENT and Beclin 1 (zeige BECN1 ELISA Kits) to the intercellular bridge during cytokinesis, and reveal a novel potential tumor suppressor mechanism for Beclin 1 (zeige BECN1 ELISA Kits).
PtdIns(3)P production is essential for proper cytokinesis. PtdIns(3)P-binding centrosomal protein FYVE-CENT and TTC19 (zeige TTC19 ELISA Kits) control cytokinesis through their translocation from the centrosome to the midbody mediated by the kinesin protein KIF13A (zeige KIF13A ELISA Kits).
phenotypic heterogeneity of SPG15 in which mental retardation or cognitive deterioration, but not all other signs of Kjellin syndrome, are associated with hereditary spastic paraplegia and significantly reduces the SPG15 locus
Increased levels of lysosomal enzymes in brains of aged knockout mice further support an alteration of the lysosomal compartment upon disruption of Zfyve26
This gene encodes a protein which contains a FYVE zinc finger binding domain. The presence of this domain is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane. Mutations in this gene are associated with autosomal recessive spastic paraplegia-15.
, zinc finger, FYVE domain containing 26
, zinc finger FYVE domain-containing protein 26-like
, FYVE domain-containing centrosomal protein
, zinc finger FYVE domain-containing protein 26