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ZNFN1A2 encodes a member of the Ikaros family of zinc-finger proteins. Zusätzlich bieten wir Ihnen ZNFN1A2 Antikörper (95) und ZNFN1A2 Kits (2) und viele weitere Produktgruppen zu diesem Protein an.
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Helios controls certain aspects of Treg-suppressive function, differentiation, and survival.
this study reports that impaired expression of the transcription factor Helios by FoxP3 (zeige FOXP3 Proteine)+ CD4 (zeige CD4 Proteine) and Qa-1 (zeige H2-T23 Proteine)-restricted CD8 (zeige CD8A Proteine) Tregs results in defective regulatory activity and autoimmunity in mice.
data suggest that a subset of DN T cells, identified by the expression of PD-1 (zeige PDCD1 Proteine) and Helios, represent self-reactive cells; results provide an explanation for the origin of DN T cells and introduce CD8 (zeige CD8A Proteine) loss as a process associated with self-Ag encounter
results demonstrate that Helios is expressed by thymic and peripheral T cells that are being driven to tolerance in response to a genuine autoantigen
identify Helios as the first marker known to diverge during positive and negative selection of thymocytes
Helios regulates IL-2 (zeige IL2 Proteine) production in Tregs by suppressing Il2 (zeige IL2 Proteine) gene transcription. Loss of Helios in Tregs breaks their anergic phenotype and results in derepression of the Il2 (zeige IL2 Proteine) locus.
Helios expression spatially coincides with the early pattern of expression of the mature markers of striatal projection neurons.
In tumor-bearing mice, Helios(+) regulatory T cells were relatively over-represented in the tumor-mass.
Data found that Helios-negative T cells are enriched for naive T cell phenotypes and vice versa. Moreover, Helios can be induced during T cell activation and proliferation, but regresses in the same cells under resting conditions.
down-regulation of NK cell activity by NKp46 (zeige NCR1 Proteine) was associated with the silencing of the Helios transcription factor in NK cells
revealed more than 170 NFAT (zeige NFATC1 Proteine)-associated proteins, half of which are involved in transcriptional regulation. Among them are many hitherto unknown interaction partners of NFATc1 (zeige NFATC1 Proteine) and NFATc2 (zeige NFAT1 Proteine) in T cells, such as Raptor (zeige RPTOR Proteine), CHEK1 (zeige CHEK1 Proteine), CREB1 (zeige CREB1 Proteine), RUNX1 (zeige RUNX1 Proteine), SATB1 (zeige SATB1 Proteine), Ikaros (zeige IKZF1 Proteine), and Helios.
this study shows that Ikaros (zeige IKZF1 Proteine) undergoes a transient increase in protein levels at the transitional single-positive CD8 (zeige CD8A Proteine)+ developmental stage before diverging in their expression patterns at later stages
The results show that high vs. low expression of Nrp-1 (zeige NELL1 Proteine) or Helios does not unequivocally identify Treg clones of thymic or peripheral origin.
Helios could be considered a more reliable marker for distinguishing thymic derived Regulatory T (tTreg) cells or peripherally induced Treg cells than Nrp1 (zeige NELL1 Proteine).
Forkhead box protein 3 (zeige HSPB3 Proteine)(+) regulatory T cells and Helios(+) subset in perinatally acquired HIV.
The immunosuppressive enzyme IL4I1 (zeige IL4I1 Proteine) expressed differentially in human induced Aiolos (zeige IKZF3 Proteine)+, but not natural Helios+, FOXP3 (zeige FOXP3 Proteine)+ Treg cells.
Ectopic expression of ATL-type Helios isoform as well as knockdown of normal Helios or Ikaros (zeige IKZF1 Proteine) promoted T-cell growth.
Foxp3 (zeige FOXP3 Proteine)+ Helios+ regulatory T cells are expanded in active systemic lupus erythematosus.
large number of ex vivo expanded functional Treg can be obtained from long-term T1D patients, although fewer expanded Treg expressed a high level of Helios
A differential role for monocyte subsets in control of Helios(+/-) Treg development that is mediated by distinct inflammatory cytokines.
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This protein forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined.
IKAROS family zinc finger 2 (Helios)
, zinc finger protein, subfamily 1A, 2 (Helios)
, ikaros family zinc finger protein 2
, zinc finger protein Helios
, ikaros-related transcription factor
, lymphoid transcription factor
, zinc finger DNA binding protein Helios