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ZBP1 encodes a Z-DNA binding protein. Zusätzlich bieten wir Ihnen Z-DNA Binding Protein 1 Antikörper (69) und Z-DNA Binding Protein 1 Proteine (10) und viele weitere Produktgruppen zu diesem Protein an.
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These results indicate that DAI is an important immuno-regulator of the porcine innate immune system
Our results show that HSV2 is detected by a plethora of PRRs including DAI protein which trigger cytokine secretion to protect the host.
DAI could function as a DNA sensor and a regulator in DNA-induced macrophage M2b polarization and lupus nephritis.
Collectively, these results demonstrate that DAI can suppress HSV-1 growth independent of DNA sensing through mechanisms involving suppression of viral genomes and regulation of ICP0.
these data indicate that ZBP1 (zeige IGF2BP1 ELISA Kits) may function as an adapter to export the Ro/Y3 RNA complex from nuclei.
Solution structure of the Zbeta domain of human DNA-dependent activator of IFN-regulatory factors and its binding modes to B (zeige TDO2 ELISA Kits)- and Z-DNAs.
hZbeta(DAI) binds to Z-DNA via an active-di B-Z transition mechanism.
These results suggest that activation of DAI might contribute to augment HIV-1 replication through DAI- NF-kappaB (zeige NFKB1 ELISA Kits) pathway.
identify ZBP1 (zeige IGF2BP1 ELISA Kits) as being essential for IRF3 (zeige IRF3 ELISA Kits) activation and interferon beta (zeige IFNB1 ELISA Kits) expression triggered by HCMV, as well as being sufficient to enhance HCMV-stimulated beta interferon (zeige IFNA ELISA Kits) transcription and secretion.
Z-DNA binding activities of two Zalpha domains in the human ZBP1 (zeige IGF2BP1 ELISA Kits), hZalpha(ZBP1 (zeige IGF2BP1 ELISA Kits)) and hZbeta(ZBP1 (zeige IGF2BP1 ELISA Kits))were characterized.
In conclusion, intracellular bacteria and cytosolic poly(dA-dT) activate IFNbeta responses in different human cells without requiring human ZBP1 (zeige IGF2BP1 ELISA Kits).
activation requires RIG-I (zeige DDX58 ELISA Kits) signaling, ubiquitination, and vRNP sensing to trigger activation of programmed cell death pathways during influenza A virus infection
These results identify DAI as a link between influenza A virus replication and RIPK3 (zeige RIPK3 ELISA Kits) activation and implicate DAI as a sensor of RNA viruses.
findings identify ZBP1 as a critical mediator of inflammation beyond its previously known role in antiviral defence and suggest that ZBP1 might be implicated in the pathogenesis of necroptosis-associated inflammatory diseases
findings indicate that the RHIM of RIPK1 is critical for preventing ZBP1/RIPK3/MLKL-dependent necroptosis during development
DAI as an important cytosolic DNA sensor, is responsible for the recognition of A/T or G/C-rich DNA derived from DNA virus.
Disruption of the in vivo interaction of KIF11 (zeige KIF11 ELISA Kits) with ZBP1 delocalizes beta-actin (zeige ACTB ELISA Kits) mRNA and affects cell migration.
Association of ribosomes and ZBP1 with the mRNA were anti-correlated both near the nucleus of primary fibroblasts and neurons and in peripheral cellular regions such as the leading edge of fibroblasts, therefore validating the hypothesis that ZBP1 spatially regulates beta-actin (zeige ACTB ELISA Kits) mRNA localized translation.
DAI interacts with RIP3 (zeige MPRIP ELISA Kits) to mediate virus-induced necrosis analogous to the RIP1 (zeige RALBP1 ELISA Kits)-RIP3 (zeige MPRIP ELISA Kits) complex controlling death receptor-induced necroptosis.
data support a direct role for ZBP1 in transport and translation of mRNA cargos in axonal regeneration in vitro and in vivo
observations underscore an integral role of DAI (DLM-1/ZBP1) in the DNA-mediated activation of innate immune responses
This gene encodes a Z-DNA binding protein. The encoded protein plays a role in the innate immune response by binding to foreign DNA and inducing type-I interferon production. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Z-DNA binding protein 1
, tumor stroma and activated macrophage protein DLM-1
, DNA-dependent activator of IFN-regulatory factor
, Z-DNA-binding protein 1
, B-actin zipcode-binding protein 1
, IGF-II mRNA-binding protein 1
, IGF2 mRNA-binding protein 1
, VICKZ family member 1
, insulin-like growth factor 2 binding protein 1
, insulin-like growth factor 2 mRNA-binding protein 1
, insulin-like growth factor 2, binding protein 1
, zipcode-binding protein-1
, DNA-dependent activator of IFN-regulatory factors
, DNA-dependent activator of IRFs
, DNA-dependent activator of interferon regulatory factors