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YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. Zusätzlich bieten wir Ihnen YY1 Transcription Factor Antikörper (147) und YY1 Transcription Factor Kits (7) und viele weitere Produktgruppen zu diesem Protein an.
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YY1 is essential for Xenopus development in neural ectoderm differentiation, neural crest specification and directing neural crest mesenchyme formation by blocking slug
Yin Yang 1 transcription factor assembly into messenger ribonucleoprotein particles requires direct RNA binding activity
Results show that the YY1-RNA interaction is highly stable, and that YY1 possesses the ability to interact with structurally divergent RNA substrates.
results suggest that YY1a regulates PS receptor expression that linked to function of PSR (zeige JMJD6 Proteine)-phagocyte mediated apoptotic cell engulfment during development
YY1 promotes zebrafish liver steatosis and lipotoxicity by inhibiting CHOP-10 (zeige DDIT3 Proteine) expression.
Study demonstrated that beta-arrestin1 (zeige ARRB1 Proteine) is critically involved in zebrafish primitive hematopoiesis, where beta-arrestin1 (zeige ARRB1 Proteine) binds to and sequesters the PcG recruiter YY1, thus relieving PcG-mediated repression of cdx4-hox (zeige MSH2 Proteine) pathway.
High YY1 expression is associated with Lung Cancer Progression.
Low YY1 expression is associated with pancreatic ductal adenocarcinoma.
PRE-PIK3C2B interacts directly with YY1 in vitro and recruits PRC2 complex in vivo. The localization of PcG proteins including YY1 to PRE-PIK3C2B in HEK cells is decreased on knock-down of either YY1 or SUZ12.
YY1 promotes mTORC2 (zeige CRTC2 Proteine)-mediated AKT (zeige AKT1 Proteine) activation
Yin Yang 1 (YY1) interacts with Seryl-tRNA synthetase (SerRS (zeige SARS Proteine)) to form a SerRS (zeige SARS Proteine)/YY1 complex which functions as a negative effector to regulate vegfa (zeige VEGFA Proteine) transcription through binding a distal segment of the vegfa (zeige VEGFA Proteine) promoter, while NFKB1 (zeige NFKB1 Proteine) serves as a positive effector through outcompeting SerRS (zeige SARS Proteine)/YY1 for binding at the same distal segment.
these results define a clinical syndrome caused by haploinsufficiency of YY1 through dysregulation of key transcriptional regulators.
Interactions of the chromatin remodeling protein INO80 with DNA, and the role of YY1 in this process have been described.
ZFs of YY1 are able to interact with multiple RNA sequences, and that their specificity is not limited to putative endogenous RNA target Xist. The mode of interaction appears to be distinct from both the DNA binding of YY1 and the RNA binding of other classical ZF proteins.
the existence of both INO80 and YY1 is required for recruiting the INO80/YY1 complex to BCCIP (zeige BCCIP Proteine) promoter region. Our findings strongly indicate that BCCIP (zeige BCCIP Proteine) is a potential target gene of the INO80/YY1 complex.
miR (zeige MLXIP Proteine)-215 is downregulated in colon cancer and it suppresses colon cancer cell proliferation, migration and invasion by directly targeting YY1
DNA binding domain of YY1 is necessary for X-chromosome inactivation in activated B cells, as ex-vivo YY1 deletion results in loss of inactive X (Xi) chromosome heterochromatin marks and up-regulation of X-linked genes.
Transcriptome analysis revealed that YY1 is required for mitochondrial gene expression, and ultrastructural analysis confirmed compromised mitochondrial integrity in the mutant intestine.
regulates broad general processes throughout all stages of B-cell differentiation: normally activates genes involved in mitochondrial bioenergetics; normally down-regulates genes involved in transcription, mRNA splicing, NF-kappaB (zeige NFKB1 Proteine) signaling pathways, the AP-1 (zeige JUN Proteine) transcription factor network, chromatin remodeling, cytokine signaling pathways, cell adhesion, and cell proliferation
Results indicate that YY1 plays an important role in regulating the balance between dark zone and light zone cells in germinal center (GCs (zeige UGCG Proteine)) and between survival and death of GC B (zeige NPR2 Proteine) cells.
YY1 is required for germinal center B cell development.
Dp71 (zeige DMD Proteine) expression in hepatic cells is carried out, in part, by YY1-, Sp1 (zeige SP1 Proteine)- and Sp3-mediated transcription from the Dp71 (zeige DMD Proteine) promoter.
this study shows that YY1 regulates the formation of terminal-effector CD8 (zeige CD8A Proteine)+ T cell fates
that yin yang 1 strongly localizes in the spermatogonial stem cells and co-localizes heterogeneously with CP2c to permit spermatogenesis
YY1 and SP1 (zeige SP1 Proteine) independently and cooperatively govern the Mesp1 (zeige MESP1 Proteine) expression during embryogenesis.
YY1 regulates lung CCL4 (zeige CCL4 Proteine) transcription in pulmonary tuberculosis.
YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1.
YY1 transcription factor
, YY1 transcription factor, like
, transcription factor YY1
, Yin Yang 1
, INO80 complex subunit S
, Yin and Yang 1 protein
, delta transcription factor
, transcriptional repressor protein YY1
, GLI-Krupple related protein
, UCR-motif DNA-binding protein
, UCRBP transcription factor
, yin and yang 1