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WHSC1L1 is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. Zusätzlich bieten wir Ihnen WHSC1L1 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
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Polyclonal WHSC1L1 Primary Antibody für WB - ABIN540242
Angrand, Apiou, Stewart, Dutrillaux, Losson, Chambon: NSD3, a new SET domain-containing gene, maps to 8p12 and is amplified in human breast cancer cell lines. in Genomics 2001
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Polyclonal WHSC1L1 Primary Antibody für WB - ABIN540244
Stec, Nagl, van Ommen, den Dunnen: The PWWP domain: a potential protein-protein interaction domain in nuclear proteins influencing differentiation? in FEBS letters 2000
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Human Polyclonal WHSC1L1 Primary Antibody für WB - ABIN316304
Yang, Liu, Bollig-Fischer, Giroux, Ethier: Transforming properties of 8p11-12 amplified genes in human breast cancer. in Cancer research 2010
This study demonstrates that over-expression of WHSC1L1 is linked to over-expression of ER-alpha (zeige ESR1 Antikörper) in SUM-44 breast cancer cells and in primary human breast cancers.
Studies indicate that the NSD methyltransferases NSD1 (zeige NSD1 Antikörper), NSD2/WHSC1/MMSET (zeige WHSC1 Antikörper) and NSD3/WHSC1L1 were overexpressed, amplified or somatically mutated in multiple types of cancer, suggesting their critical role in cancer.
Results demonstrate that the AML (zeige RUNX1 Antikörper) maintenance function of BRD4 (zeige BRD4 Antikörper) requires its interaction with the short isoform of NSD3 lacking the methyltransferase domain. This protein is an adaptor that sustains leukemia by linking BRD4 (zeige BRD4 Antikörper) to the CHD8 (zeige CHD8 Antikörper) chromatin remodeler.
The results describe the binding of NSD1 (zeige NSD1 Antikörper), 2 and 3 catalytic domains (CD) on histone tails through recognition of histone-lysine and methylation properties.
The involvement of the NSD3 methyltransferase as a component of the NUT fusion protein oncogenic complex identifies a new potential therapeutic target.
PPAPDC1B (zeige PPAPDC1B Antikörper) and WHSC1L1 played a major role in regulating the survival of breast cancer, pancreatic adenocarcinoma and small-cell lung cancer-derived cell lines.
Data indicate that siRNA attenuated the expression levels of CCNG1 (zeige CCNG1 Antikörper) and NEK7 (zeige NEK7 Antikörper), implying that WHSC1L1 appears to activate the expression of CCNG1 (zeige CCNG1 Antikörper) and NEK7 (zeige NEK7 Antikörper) in cancer cells.
methyltransferase NSD3 has chromatin-binding motifs, PHD5-C5HCH, that are distinct from other NSD (nuclear receptor SET domain) family members in their histone H3 (zeige HIST3H3 Antikörper) recognition
Functional studies with Brd4 (zeige BRD4 Antikörper) indicate that the ET domain mediates pTEFb (zeige CDK9 Antikörper)-independent transcriptional activation through a subset of these associated factors, including NSD3.
Overexpression of WHSC1L1 gene is associated with breast cancer.
This study reveals a critical role of NSD3-mediated IRF3 (zeige IRF3 Antikörper) methylation in enhancing antiviral innate immunity.
WHSC1L1-L acts as a histone methyltransferase in podocytes and regulates nephrin (zeige NPHS1 Antikörper) gene expression, which may in turn contribute to the integrity of the slit diaphragm of the glomerular filtration barrier.
This gene is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. The function of the protein has not been determined. Two alternatively spliced variants have been described.
histone-lysine N-methyltransferase NSD3
, Wolf-Hirschhorn syndrome candidate 1-like 1
, histone-lysine N-methyltransferase NSD3-like
, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine
, WHSC1-like protein 1
, nuclear SET domain-containing protein 3
, protein whistle
, wolf-Hirschhorn syndrome candidate 1-like protein 1 homolog