Werner Helicase Interacting Protein 1 Proteine (WRNIP1)

Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). Zusätzlich bieten wir Ihnen WRNIP1 Antikörper (77) und WRNIP1 Kits (3) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
WRNIP1 56897 Q96S55
Maus WRNIP1 WRNIP1 78903 Q91XU0
WRNIP1 282835 Q8CG07
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Top WRNIP1 Proteine auf antikoerper-online.de

Showing 3 out of 3 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$7,759.50
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 10 bis 12 Tage
$785.40
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,916.00
Details

WRNIP1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,
Rat (Rattus)

Weitere Proteine zu Werner Helicase Interacting Protein 1 (WRNIP1) Interaktionspartnern

Human Werner Helicase Interacting Protein 1 (WRNIP1) Interaktionspartner

  1. findings define the WHIP-TRIM14 (zeige TRIM14 Proteine)-PPP6C (zeige PPP6C Proteine) mitochondrial signalosome required for RIG-I (zeige DDX58 Proteine)-mediated innate antiviral immunity.

  2. WRNIP1 connects PCNA (zeige PCNA Proteine) monoubiquitination with ATMIN (zeige ATMIN Proteine)/ATM (zeige ATM Proteine) to activate ATM (zeige ATM Proteine) signalling in response to replication stress and contribute to the maintenance of genomic stability.

  3. The authors show that WRNIP1 is directly involved in preventing uncontrolled MRE11 (zeige MRE11A Proteine)-mediated degradation of stalled replication forks by promoting RAD51 (zeige RAD51 Proteine) stabilization on ssDNA.

  4. We propose that UBZ domains can be divided into at least two different types in terms of the ubiquitin-binding surfaces: the pol type and the WRNIP1 type

  5. results suggest that WRNIP1 functions upstream of Poleta in the response to UV irradiation

  6. Mutated WRNIP1 with a deleted ATPase domain or with mutations in lysine residues accumulated in laser light irradiated sites, suggesting that the ATPase domain of WRNIP1 and ubiquitination of WRNIP1 are dispensable for the accumulation.

  7. WHIP was identified as a partner/component of the nuclear envelope/nuclear pore complex (NPC (zeige NPC1 Proteine)) and set forth to investigate a role for the protein positioned at the NPC (zeige NPC1 Proteine).

  8. These results indicate that WRNIP1 functions as a modulator for initiation or restart events during pol delta-mediated DNA synthesis and that its ATPase activity is utilized to sense DNA ends and to regulate the extent of stimulation.

  9. Werner helicase-interacting protein 1 binds polyubiquitin (zeige UBB Proteine) via its zinc finger domain

  10. analysis of the composite and regulated topography of Wrnip1 in the human nucleus highlights its potential role in replication and other nuclear transactions

Mouse (Murine) Werner Helicase Interacting Protein 1 (WRNIP1) Interaktionspartner

  1. Mutations in the Walker A motifs of the two proteins revealed that WRNIP1, but not WRN, must bind ATP before an efficient interaction can occur.

WRNIP1 Protein Überblick

Protein Überblick

Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene.

Genbezeichner und Symbole assoziert mit WRNIP1

  • Werner helicase interacting protein 1 (WRNIP1)
  • Werner helicase interacting protein 1 L homeolog (wrnip1.L)
  • Werner helicase interacting protein 1 (wrnip1)
  • ATPase WRNIP1 (EDI_075920)
  • ATPase WRNIP1 (CpipJ_CPIJ017857)
  • ATPase WRNIP1 (PITG_07216)
  • ATPase WRNIP1 (VDBG_02914)
  • Werner helicase interacting protein 1 (Wrnip1)
  • ATPase WRNIP1 (PGTG_08805)
  • 4833444L21Rik Protein
  • bA420G6.2 Protein
  • RP11-420G6.2 Protein
  • Whip Protein
  • Wrnip Protein
  • wrnip1 Protein
  • zgc:85976 Protein

Bezeichner auf Proteinebene für WRNIP1

ATPase WRNIP1 , Werner helicase interacting protein 1 , Werner helicase-interacting protein 1 , putative helicase RUVBL , Werner helicasae interacting protein 1 , Werner syndrome homolog interacting protein , werner helicase-interacting protein 1

GENE ID SPEZIES
788824 Bos taurus
462392 Pan troglodytes
707250 Macaca mulatta
734231 Xenopus laevis
56897 Homo sapiens
405856 Danio rerio
5882536 Entamoeba dispar SAW760
6052914 Culex quinquefasciatus
9471556 Phytophthora infestans T30-4
9532917 Verticillium alfalfae VaMs.102
78903 Mus musculus
282835 Rattus norvegicus
395089 Gallus gallus
100158593 Xenopus (Silurana) tropicalis
10529992 Puccinia graminis f. sp. tritici CRL 75-36-700-3
100595079 Nomascus leucogenys
100155921 Sus scrofa
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