anti-WW Domain Containing E3 Ubiquitin Protein Ligase 1 (WWP1) Antikörper

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Zusätzlich bieten wir Ihnen WWP1 Proteine (3) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
WWP1 11059 Q9H0M0
WWP1 107568 Q8BZZ3
WWP1 297930  
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Top anti-WWP1 Antikörper auf antikoerper-online.de

Showing 10 out of 28 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert IHC, WB WB Suggested Anti-WWP1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: 293T cell lysate 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
Details
Human Maus Unkonjugiert IF, WB Immunofluorescence of monoclonal antibody to WWP1 on A-431 cell (antibody concentration 10 µg/mL). WWP1 monoclonal antibody (M01), clone 1A7 Western Blot analysis of WWP1 expression in A-431. 0.1 mg Anmelden zum Anzeigen 12 bis 16 Tage
454,76 €
Details
Human Maus Unkonjugiert ELISA, WB Western Blot analysis of WWP1 expression in transfected 293T cell line by WWP1 monoclonal antibody (M01A), clone 1A7.Lane 1: WWP1 transfected lysate(105.2 KDa).Lane 2: Non-transfected lysate. Western Blot detection against Immunogen (37.73 KDa) . 200 μL Anmelden zum Anzeigen 7 bis 8 Tage
369,60 €
Details
Human Maus Unkonjugiert IF, IHC (p), IP, ELISA, WB Immunoperoxidase of monoclonal antibody to WWP1 on formalin-fixed paraffin-embedded human stomach. [antibody concentration 3 ug/ml] Immunofluorescence of monoclonal antibody to WWP1 on A-431 cell. [antibody concentration 10 ug/ml] 100 μg Anmelden zum Anzeigen 7 bis 8 Tage
369,60 €
Details
Fledermaus Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
653,02 €
Details
Human Maus Unkonjugiert IF, ELISA, WB 100 μg Anmelden zum Anzeigen 11 bis 14 Tage
635,55 €
Details
Human Kaninchen Unkonjugiert WB WWP1 antibody used at 1 ug/ml to detect target protein. 50 μg Anmelden zum Anzeigen 6 bis 8 Tage
460,89 €
Details
Human Kaninchen Unkonjugiert IF (p), IHC (p)   100 μL Anmelden zum Anzeigen 9 bis 12 Tage
304,36 €
Details
Human Maus Unkonjugiert ELISA, WB Western Blot detection against Immunogen (38.1 KDa) . 50 μL Anmelden zum Anzeigen 7 bis 8 Tage
241,60 €
Details
Human Kaninchen Unkonjugiert WB Western Blot analysis of WWP1 expression in transfected 293T cell line by WWP1 MaxPab polyclonal antibody.Lane 1: WWP1 transfected lysate(105.20 KDa).Lane 2: Non-transfected lysate. 100 μg Anmelden zum Anzeigen 7 bis 8 Tage
358,40 €
Details

WWP1 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität
Human , ,
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Mouse (Murine) ,


Rat (Rattus) ,


Am meisten referenzierte anti-WWP1 Antikörper

  1. Human Monoclonal WWP1 Primary Antibody für IF, IHC (p) - ABIN564794 : Edwards, Clowes, Tsang, Connell, Sanderson, Luzio, Reid: Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5. in The Biochemical journal 2009 (PubMed)
    Zeige alle 6 Referenzen für 564794

  2. Human Monoclonal WWP1 Primary Antibody für IF, WB - ABIN393446 : Li, Zhou, Alimandi, Chen: WW domain containing E3 ubiquitin protein ligase 1 targets the full-length ErbB4 for ubiquitin-mediated degradation in breast cancer. in Oncogene 2009 (PubMed)
    Zeige alle 5 Referenzen für 393446

  3. Cow (Bovine) Polyclonal WWP1 Primary Antibody für IHC, WB - ABIN2774928 : Heidecker, Lloyd, Soheilian, Nagashima, Derse: The role of WWP1-Gag interaction and Gag ubiquitination in assembly and release of human T-cell leukemia virus type 1. in Journal of virology 2007 (PubMed)

  4. Human Monoclonal WWP1 Primary Antibody für ELISA, WB - ABIN524447 : Subik, Shu, Wu, Liang, Hicks, Boyce, Schiffhauer, Chen, Chen, Tang, Xing: The ubiquitin E3 ligase WWP1 decreases CXCL12-mediated MDA231 breast cancer cell migration and bone metastasis. in Bone 2012 (PubMed)

Weitere Antikörper gegen WWP1 Interaktionspartner

Human WW Domain Containing E3 Ubiquitin Protein Ligase 1 (WWP1) Interaktionspartner

  1. Knock-down of WWP1 abrogates DNA damage-induced down-regulation of DeltaNp63alphaand partially rescues cell apoptosis

  2. Describe an autoinhibitory mechanism for WWP1 ubiquitin ligase involving a linker-HECT domain interaction. This intramolecular interaction traps the HECT enzyme in its inactive state and can be relieved by linker phosphorylation.

  3. results demonstrate that WWP1 catalyzes the formation of Ub chains through a sequential addition mechanism, in which Ub monomers are transferred in a successive fashion to the substrate, and that ubiquitination by WWP1 requires the presence of a low-affinity, noncovalent Ub-binding site within the HECT domain.

  4. Study shows that WWP1 was upregulated in prostate cancer (PCa (zeige FLVCR1 Antikörper)) clinical specimens and contributed to cancer cell invasion, indicating that this target of Mir (zeige MLXIP Antikörper)-452 functioned as an oncogene (zeige RAB1A Antikörper).

  5. Overexpression of WWP1 promotes tumorigenesis in patients with hepatocellular carcinoma.

  6. PTPN14 (zeige PTPN14 Antikörper), a Pez (zeige PTPN14 Antikörper) mammalian homolog, is degraded by overexpressed Su(dx) or Su(dx) homologue WWP1 in mammalian cells.

  7. miR (zeige MLXIP Antikörper)-21 overexpression or WWP1 knockdown in endothelial progenitor cells significantly activates the TGFbeta (zeige TGFB1 Antikörper) signaling pathway and inhibits cell proliferation.

  8. The cancer-driven alteration of WWP1 culminates in excessive TbetaRI (zeige TGFBR1 Antikörper) degradation and attenuated TGFbeta1 (zeige TGFB1 Antikörper) cytostatic signaling, a consequence that could conceivably confer tumorigenic properties to WWP1.

  9. Results suggest that elevated transcription and expression levels of ubiquitin ligase E3s WWP1, Smurf1 (zeige SMURF1 Antikörper) and Smurf2 (zeige SMURF2 Antikörper) genes may be the mechanisms of occurrence, development and metastasis of prostate cancer.

  10. Most notably, WWP1 downregulation both inactivated PTEN (zeige PTEN Antikörper)-Akt (zeige AKT1 Antikörper) signaling pathway in MKN-45 and AGS (zeige JAG1 Antikörper) cells. our findings suggest that WWP1 acts as an oncogenic factor and should be considered as a novel interfering molecular target for gastric carcinoma

Mouse (Murine) WW Domain Containing E3 Ubiquitin Protein Ligase 1 (WWP1) Interaktionspartner

  1. Atypical ubiquitination by E3 ligase WWP1 inhibits the proteasome-mediated degradation of mutant huntingtin (zeige HTT Antikörper). This suggests that the E3 ligase WWP1 is involved in the pathogenesis of Huntington's disease; therefore, it may be a novel target for therapeutic intervention.

  2. Cardiomyocyte-specific overexpression of Wwp1 contributes to reduction in Connexin 43 (zeige GJA1 Antikörper) and arrhythmogenesis.

  3. Wwp1 negatively regulates osteoblast functions.

  4. WWP1 functions as an E3 ligase when cells are stimulated with LPS (zeige TLR4 Antikörper) by binding to TRAF6 (zeige TRAF6 Antikörper) and promoting K48-linked polyubiquitination. This results in the proteasomal degradation of TRAF6 (zeige TRAF6 Antikörper)

  5. WWP1 down-regulates AMPKalpha2 under high glucose culture conditions via the ubiquitin-proteasome pathway

  6. Wwp1 promotes ubiquitination and degradation of JunB (zeige JUNB Antikörper), an AP-1 (zeige JUN Antikörper) transcription factor that positively regulates osteoblast differentiation.

WWP1 Antigen-Profil

Protein Überblick

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1\; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF.

Genbezeichner und Symbole assoziert mit WWP1

  • SMAD specific E3 ubiquitin protein ligase 1 (smurf1) Antikörper
  • WW domain containing E3 ubiquitin protein ligase 1 (WWP1) Antikörper
  • WW domain containing E3 ubiquitin protein ligase 1 (wwp1) Antikörper
  • WW domain containing E3 ubiquitin protein ligase 1 (Wwp1) Antikörper
  • 8030445B08Rik Antikörper
  • AIP5 Antikörper
  • hSDRP1 Antikörper
  • SDRP1 Antikörper
  • Tiul1 Antikörper
  • wu:fb30b12 Antikörper
  • WWP1 Antikörper
  • zgc:66401 Antikörper

Bezeichner auf Proteinebene für WWP1

E3 ubiquitin ligase SMURF1 , E3 ubiquitin-protein ligase SMURF1 , WW domain containing E3 ubiquitin protein ligase 1 , smad ubiquitination regulatory factor 1 , WW domain-containing protein 1 , NEDD4-like E3 ubiquitin-protein ligase WWP1 , Nedd-4-like ubiquitin-protein ligase , TGIF-interacting ubiquitin ligase 1 , atrophin-1 interacting protein 5 , atrophin-1-interacting protein 5

GENE ID SPEZIES
321695 Danio rerio
464269 Pan troglodytes
100038255 Xenopus (Silurana) tropicalis
100157283 Sus scrofa
420212 Gallus gallus
11059 Homo sapiens
477930 Canis lupus familiaris
513789 Bos taurus
107568 Mus musculus
297930 Rattus norvegicus
Ausgewählte Anbieter für anti-WWP1 (WWP1) Antikörper
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