WNK Lysine Deficient Protein Kinase 1 Proteine (WNK1)

WNK1 encodes a member of the WNK subfamily of serine/threonine protein kinases. Zusätzlich bieten wir Ihnen WNK1 Antikörper (167) und WNK1 Kits (7) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
WNK1 65125 Q9H4A3
Maus WNK1 WNK1 232341 P83741
Ratte WNK1 WNK1 116477 Q9JIH7
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Showing 6 out of 7 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$405.71
Details
Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
$333.33
Details
Baculovirus infected Insect Cells Human GST tag   5 μg Anmelden zum Anzeigen 10 bis 12 Tage
$322.08
Details
Insektenzellen Human GST tag   5 μg Anmelden zum Anzeigen 11 bis 12 Tage
$470.40
Details
Insektenzellen Human GST tag   10 μg Anmelden zum Anzeigen 3 bis 4 Tage
$310.00
Details
Escherichia coli (E. coli) Human T7 tag,His tag   100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$704.00
Details

WNK1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
,

Weitere Proteine zu WNK Lysine Deficient Protein Kinase 1 (WNK1) Interaktionspartnern

Human WNK Lysine Deficient Protein Kinase 1 (WNK1) Interaktionspartner

  1. Akt3 (zeige AKT3 Proteine) constitutively suppresses macropinocytosis in macrophages through a novel WNK1/SGK1 (zeige SGK1 Proteine)/Cdc42 (zeige CDC42 Proteine) pathway.

  2. NKCC1 (zeige SLC12A2 Proteine) and KCCs are coordinately regulated by L-WNK1 isoforms.

  3. Single nucleotide polymorphisms STK39 (zeige STK39 Proteine) and WNK were associated with hypertension and BP in our multicenter Belgian case-control study

  4. these data provide insight into the mechanism regulating Cl(-) homeostasis in immature neurons, and suggest that WNK1-regulated changes in KCC2 (zeige SLC12A5 Proteine) phosphorylation contribute to the developmental excitatory-to-inhibitory GABA sequence.

  5. Identify a new chimeric transcript generated by the fusion of WNK1 and B4GALNT3 genes, correlated with B4GALNT3 overexpression in papillary thyroid carcinoma.

  6. a novel gene, WNK1, for susceptibility to pelvic organ prolapse

  7. findings indicate that the proline-rich exons are modular cassettes that convert WNK1 into a NEDD4-2 (zeige NEDD4L Proteine) substrate, thereby linking aldosterone and other NEDD4-2 (zeige NEDD4L Proteine)-suppressing antinatriuretic hormones to NCC (zeige SLC12A3 Proteine) phosphorylation status.

  8. enhances BK channel function by reducing ERK1/2 signaling-mediated lysosomal degradation of the channel

  9. conclude that although multiple candidate genes are involved in development of hypertension, the genetic polymorphism in WNK1 is not a major contributor to the observed variability in blood pressure and familial clustering risk of hypertension

  10. study identifies a separation of functions for the WNK1-activated protein kinases OSR1 (zeige OXSR1 Proteine) and SPAK (zeige STK39 Proteine) in mediating proliferation, invasion, and gene expression in endothelial cells

Pig (Porcine) WNK Lysine Deficient Protein Kinase 1 (WNK1) Interaktionspartner

  1. HSN2 is a nervous system-specific exon of the WNK1 gene (WNK1/HSN2 isoform).

Chimpanzee WNK Lysine Deficient Protein Kinase 1 (WNK1) Interaktionspartner

  1. HSN2 is a nervous system-specific exon of the WNK1 gene (WNK1/HSN2 isoform).

Rhesus Monkey WNK Lysine Deficient Protein Kinase 1 (WNK1) Interaktionspartner

  1. HSN2 is a nervous system-specific exon of the WNK1 gene (WNK1/HSN2 isoform).

Xenopus laevis WNK Lysine Deficient Protein Kinase 1 (WNK1) Interaktionspartner

  1. HSN2 is a nervous system-specific exon of the WNK1 gene (WNK1/HSN2 isoform).

Horse (Equine) WNK Lysine Deficient Protein Kinase 1 (WNK1) Interaktionspartner

  1. HSN2 is a nervous system-specific exon of the WNK1 gene (WNK1/HSN2 isoform).

Mouse (Murine) WNK Lysine Deficient Protein Kinase 1 (WNK1) Interaktionspartner

  1. The differential regulation of ROMK (zeige KCNJ1 Proteine), large-conductance Ca(2 (zeige CA2 Proteine)+)-activated K(+) (BK) channel (zeige KCNMA1 Proteine), BK-alpha and NKCC2 (zeige SLC12A1 Proteine) between female and male mice, at least, were partly mediated via WNK1 pathway, which may contribute to the sexual dimorphism of plasma K(+) and blood pressure control.

  2. this study identified the WNK1 kinase as a regulator of both integrin-mediated adhesion and T cell migration

  3. Akt3 (zeige AKT3 Proteine) constitutively suppresses macropinocytosis in macrophages through a novel WNK1/SGK1 (zeige SGK1 Proteine)/Cdc42 (zeige CDC42 Proteine) pathway.

  4. Electrophysiological analysis showed that WNK1/HSN2 shifted the concentration of Cl(-)such that GABA signaling resulted in a less hyperpolarized state (increased neuronal activity) rather than a more hyperpolarized state (decreased neuronal activity) in mouse spinal nerves.

  5. A high-K(+) diet induced an increase in L-WNK1 expression selectively in intercalated cells and may contribute to enhanced BK channel (zeige KCNMA1 Proteine) expression and K(+) secretion in collecting ducts.

  6. these data provide insight into the mechanism regulating Cl(-) homeostasis in immature neurons, and suggest that WNK1-regulated changes in KCC2 (zeige SLC12A5 Proteine) phosphorylation contribute to the developmental excitatory-to-inhibitory GABA sequence.

  7. findings indicate that the proline-rich exons are modular cassettes that convert WNK1 into a NEDD4-2 (zeige NEDD4L Proteine) substrate, thereby linking aldosterone and other NEDD4-2 (zeige NEDD4L Proteine)-suppressing antinatriuretic hormones to NCC (zeige SLC12A3 Proteine) phosphorylation status.

  8. enhances BK channel function by reducing ERK1/2 signaling-mediated lysosomal degradation of the channel

  9. increased protein expression levels of WNK1 and WNK4 (zeige WNK4 Proteine) kinases cause PHAII by KLHL3 (zeige KLHL3 Proteine) R528H mutation due to impaired KLHL3 (zeige KLHL3 Proteine)-Cullin3-mediated ubiquitination.

  10. study identifies a separation of functions for the WNK1-activated protein kinases OSR1 (zeige OSR1 Proteine) and SPAK (zeige STK39 Proteine) in mediating proliferation, invasion, and gene expression in endothelial cells

WNK1 Protein Überblick

Protein Überblick

This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.

Genbezeichner und Symbole assoziert mit WNK1

  • WNK lysine deficient protein kinase 1 (WNK1)
  • WNK lysine deficient protein kinase 1 L homeolog (wnk1.L)
  • WNK lysine deficient protein kinase 1 (wnk1)
  • serine/threonine-protein kinase WNK1 (LOC100056745)
  • WNK lysine deficient protein kinase 1 (Wnk1)
  • with no lysine (K) kinase 1 (WNK1)
  • 6430573H23Rik Protein
  • ATWNK1 Protein
  • EG406236 Protein
  • hsan2 Protein
  • Hsn2 Protein
  • kdp Protein
  • mKIAA0344 Protein
  • p65 Protein
  • pha2c Protein
  • Prkwnk1 Protein
  • psk Protein
  • T9J14.14 Protein
  • T9J14_14 Protein
  • with no lysine (K) kinase 1 Protein
  • WNK1 Protein
  • ZIK4 Protein

Bezeichner auf Proteinebene für WNK1

WNK lysine deficient protein kinase 1 isoform , erythrocyte 65 kDa protein , prostate-derived sterile 20-like kinase , protein kinase with no lysine 1 , serine/threonine-protein kinase WNK1 , WNK lysine deficient protein kinase 1 , serine/threonine-protein kinase WNK1-like , protein kinase lysine-deficient 1

GENE ID SPEZIES
65125 Homo sapiens
406235 Sus scrofa
427925 Gallus gallus
451739 Pan troglodytes
477728 Canis lupus familiaris
506433 Bos taurus
706493 Macaca mulatta
734160 Xenopus laevis
100017207 Monodelphis domestica
100036683 Xenopus (Silurana) tropicalis
100056745 Equus caballus
100350906 Oryctolagus cuniculus
100436057 Pongo abelii
100594288 Nomascus leucogenys
232341 Mus musculus
116477 Rattus norvegicus
819651 Arabidopsis thaliana
100729855 Cavia porcellus
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