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WDFY3 encodes a phosphatidylinositol 3-phosphate-binding protein that functions as a master conductor for aggregate clearance by autophagy. Zusätzlich bieten wir Ihnen und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal WDFY3 Primary Antibody für EM, ICC - ABIN315857
Sommi, Necchi, Vitali, Montagna, De Luigi, Salmona, Ricci, Solcia: PaCS is a novel cytoplasmic structure containing functional proteasome and inducible by cytokines/trophic factors. in PLoS ONE 2013
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Human Monoclonal WDFY3 Primary Antibody für ELISA, WB - ABIN949075
Orosco, Ross, Cates, Scott, Wu, Sohn, Pleasure, Pleasure, Adamopoulos, Zarbalis: Loss of Wdfy3 in mice alters cerebral cortical neurogenesis reflecting aspects of the autism pathology. in Nature communications 2014
Cow (Bovine) Polyclonal WDFY3 Primary Antibody für WB - ABIN2784358
Hillier, Graves, Fulton, Fulton, Pepin, Minx, Wagner-McPherson, Layman, Wylie, Sekhon, Becker, Fewell, Delehaunty, Miner, Nash, Kremitzki, Oddy, Du, Sun, Bradshaw-Cordum, Ali, Carter, Cordes, Harris et al.: Generation and annotation of the DNA sequences of human chromosomes 2 and 4. ... in Nature 2005
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we demonstrate that normally ALFY attenuates the canonical Wnt (zeige WNT2 Antikörper) signaling pathway via autophagy-dependent removal specifically of aggregates of DVL3 (zeige DVL3 Antikörper) and not of Dvl1 (zeige DVL1 Antikörper) or Dvl2 (zeige DVL2 Antikörper).
ALFY binds selectively to LC3C (zeige MAP1LC3C Antikörper) and the GABARAPs through a LC3 (zeige MAP1LC3A Antikörper)-interacting region in its WD40 domain (zeige DCAF12L2 Antikörper).
increasing Alfy-mediated protein degradation may be beneficial in some organs, but may be detrimental in others
Data suggest that p62 (zeige GTF2H1 Antikörper) and ALFY interact to organize misfolded, ubiquitinated proteins into protein bodies that become degraded by autophagy.
The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy.
Alfy might target cytosolic protein aggregates for autophagic degradation.
Alfy translocalization likely is involved in the pathogenesis of amyotrophic lateral sclerosis.
Wdfy3 is important in regulating neural progenitor divisions, neural migration, cerebral expansion and functional organization in the developing brain. Loss-of-function leads to pathological changes characteristic of autism spectrum disorders.
gene expression profiling; in situ hybridization analysis revealed that the expressed BWF1 mRNA was restricted to the marginal region both in E14 (zeige NPAT Antikörper) and E16 (zeige SLC7A5 Antikörper) embryonic brain, but became diffuse after birth
This gene encodes a phosphatidylinositol 3-phosphate-binding protein that functions as a master conductor for aggregate clearance by autophagy. This protein shuttles from the nuclear membrane to colocalize with aggregated proteins, where it complexes with other autophagic components to achieve macroautophagy-mediated clearance of these aggregated proteins. However, it is not necessary for starvation-induced macroautophagy.
WD repeat and FYVE domain containing 3
, WD repeat and FYVE domain-containing protein 3
, autophagy-linked FYVE protein
, beach domain, WD repeat and FYVE domain-containing protein 1
, galactosyltransferase 3 beta 1, 4