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ERG encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. Zusätzlich bieten wir Ihnen V-Ets erythroblastosis Virus E26 Oncogene Homolog (Avian) Antikörper (115) und V-Ets erythroblastosis Virus E26 Oncogene Homolog (Avian) Proteine (11) und viele weitere Produktgruppen zu diesem Protein an.
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KLF2 (zeige KLF2 ELISA Kits) and ERG associate in a physical complex and the two proteins synergistically activate transcription of Flk1 (zeige KDR ELISA Kits).
loss of ERG and FLI1 (zeige FLI1 ELISA Kits) might contribute to the pathogenesis of vascular lung complications through the induction of inflammation.
Combined, these data suggest a possible pathway linking GDF5 (zeige GDF5 ELISA Kits), ERG and downstream factors in the processes of chondrocyte differentiation during articular joint formation.
Our study reveals that ERG has essential and cell autonomous roles in endothelial cell development and blood vessel maintenance.
We show that the gene expression signature specifically attributable to trisomy of Erg in the murine model is strongly correlated with gene expression changes in human Down syndrome hematopoietic cells.
Articular cartilage endurance and resistance to osteoarthritic changes require transcription factor Erg.
ERG plays a critical role in coordinating the balance between self-renewal and differentiation of HSCs.
ERG activates the transcriptional program regulated by YAP1 (zeige YAP1 ELISA Kits) of the Hippo signaling pathway and found that prostate-specific activation of either ERG or YAP1 (zeige YAP1 ELISA Kits) in mice induces similar transcriptional changes and results in age-related prostate tumors.
ERG and APLNR (zeige APLNR ELISA Kits) are essential for endothelial homeostasis in venules in the lung and that perturbation in ERG-APLNR (zeige APLNR ELISA Kits) signaling is crucial for the development of pulmonary veno-occlusive disease.
Regulation of Erg by TGF-beta (zeige TGFB1 ELISA Kits) was confirmed in these cells.
Ablation of the oncogenic transcription factor ERG by deubiquitinase inhibition in prostate cancer.
Data show that tumors displaying TMPRSS2 (zeige TMPRSS2 ELISA Kits)-ERG fusions that retained interstitial genes were less likely to be associated with biochemical recurrence
ERG, FLI1 (zeige FLI1 ELISA Kits), TAL1 (zeige TAL1 ELISA Kits), and RUNX1 (zeige RUNX1 ELISA Kits) bind at all AML1 (zeige RUNX1 ELISA Kits)-ETO (zeige RUNX1T1 ELISA Kits)-occupied regulatory regions, including those of the AML1 (zeige RUNX1 ELISA Kits)-ETO (zeige RUNX1T1 ELISA Kits) gene itself, suggesting their involvement in regulating AML1 (zeige RUNX1 ELISA Kits)-ETO (zeige RUNX1T1 ELISA Kits) expression levels.
four oncogenic ETS (zeige ETS1 ELISA Kits) (ERG, ETV1 (zeige ETV1 ELISA Kits), ETV4 (zeige ETV4 ELISA Kits), and ETV5), and no other ETS (zeige ETS1 ELISA Kits), interact with the Ewing's sarcoma breakpoint protein, EWS (zeige EWSR1 ELISA Kits).
We demonstrate a role for inflammation-induced oxidative stress in the formation of DNA breaks leading to recurrent TMPRSS2 (zeige TMPRSS2 ELISA Kits)-ERG gene fusions. The transcriptional status and epigenetic features of the target genes influence this effect.
ERG signaling in prostate cancer is driven through PRMT5 (zeige PRMT5 ELISA Kits)-dependent methylation of the androgen receptor (zeige AR ELISA Kits).
NOTCH (zeige NOTCH1 ELISA Kits) pathway inhibition antagonizes the growth and invasion of transmembrane protease serine 2 (TMPRSS2 (zeige TMPRSS2 ELISA Kits))-transforming protein ERG (ERG) (T2E) -positive prostate cancer cells.
findings have identified critical molecular mechanisms involving ERK (zeige EPHB2 ELISA Kits)-mediated ERG activation that could be exploited for therapeutic intervention in ERG-positive prostate cancers.
Detection of Gene Rearrangements in Circulating Tumor Cells: Examples of ALK (zeige ALK ELISA Kits)-, ROS1 (zeige ROS1 ELISA Kits)-, RET (zeige RET ELISA Kits)-Rearrangements in Non-Small-Cell Lung Cancer and ERG-Rearrangements in Prostate Cancer.(
The TMPRSS2 (zeige TMPRSS2 ELISA Kits)-ERG gene fusion is the most frequently observed genetic aberration in Prostate cancer.
Loss of ERG is associated with prostate tumors.
fli1 (zeige FLI1 ELISA Kits), and etsrp, demonstrated that erg (zeige KCNH2 ELISA Kits) and fli1 (zeige FLI1 ELISA Kits) act cooperatively and are required for angiogenesis possibly via direct regulation of an endothelial cell junction molecule, VE-cadherin (zeige CDH5 ELISA Kits)
A combination of gain-of-function and loss-of-function studies suggested a redundant yet specific role for erg (zeige KCNH2 ELISA Kits) in both angioblast specification/proliferation and early angiogenesis, and a synergistic interaction with the critical ETS (zeige ETS1 ELISA Kits) factor etsrp.
This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
v-ets erythroblastosis virus E26 oncogene like
, Ether-a-go-go-related gene potassium channel 1
, Potassium voltage-gated channel subfamily H member 2
, v-ets erythroblastosis virus E26 oncogene homolog (avian)
, v-ets erythroblastosis virus E26 oncogene homolog
, erg gene (erg_E)
, vascular ETS factor
, transcriptional regulator ERG
, avian erythroblastosis virus E-26 (v-ets) oncogene related
, TMPRSS2/ERG fusion
, transcriptional regulator ERG (transforming protein ERG)
, v-ets avian erythroblastosis virus E26 oncogene related
, transcriptional regulator Erg