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UPK2 encodes one of the proteins of the highly conserved urothelium-specific integral membrane proteins of the asymmetric unit membrane which forms urothelium apical plaques in mammals. Zusätzlich bieten wir Ihnen Uroplakin 2 Antikörper (13) und Uroplakin 2 Kits (2) und viele weitere Produktgruppen zu diesem Protein an.
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Human Uroplakin 2 Protein expressed in Escherichia coli (E. coli) - ABIN1098745
Jenkins, Bitner-Glindzicz, Malcolm, Allison, de Bruyn, Flanagan, Thomas, Belk, Feather, Bingham, Southgate, Woolf: Mutation analyses of Uroplakin II in children with renal tract malformations. in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2006
These results suggest that whereas GATA-3 and uroplakin II may be most useful in the diagnosis of urothelial carcinoma metastasis, p40 may be additionally suited as a prognostic marker.
UPII, GATA3, and p40, when used in combination, are highly sensitive in the differential diagnosis of invasive urothelial carcinoma.
UPII was highly specific/moderately sensitive for urothelial carcinoma. May be a potentially useful marker to identify urothelial lineage and help distinguish UC from prostate cancer or, in conjunction with GATA3 (zeige GATA3 Proteine), from metastatic breast cancer.
UPII demonstrates a significantly higher sensitivity than UPIII (zeige UPK3A Proteine) in conventional and variant urothelial carcinomas
Uroplakin II antibody BC21 demonstrated superior sensitivity and specificity in urothelial carcinoma, compared with uroplakin III (zeige UPK3A Proteine), suggesting an advantage in differential diagnosis of urothelial carcinoma and in the detection of tumors of unknown origin.
combination of prostate stem cell antigen (zeige PSCA Proteine) enhancer and uroplakin II promoter is feasible in constructing bladder cancer-specific vectors
study offers no definitive support for uroplakin II mutations causing human renal tract malformations
The despites a lower level of expression, UPII maintain its plaque association in urothelial preneoplastic lesions.
Bladder-specific autoimmune response sufficient to induce inflammation and interstitial cystitis occurs in mice following immunization with recombinant murine UPK2.
The UPII knockout abolished plaque formation, indicating that both uroplakin heterodimers (UPIa (zeige UPK1A Proteine)/II and UPIb (zeige UPK1B Proteine)/III or IIIb) are required for plaque assembly.
HNF4 (zeige HNF4A Proteine) positively regulates pUPII gene promoter activity.
This gene encodes one of the proteins of the highly conserved urothelium-specific integral membrane proteins of the asymmetric unit membrane which forms urothelium apical plaques in mammals. The asymmetric unit membrane is believed to strengthen the urothelium by preventing cell rupture during bladder distention. The encoded protein is expressed in the peripheral blood of bladder cancer patients with transitional cell carcinomas.
, uroplakin II