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Unc5c product belongs to the UNC-5 family of netrin receptors. Zusätzlich bieten wir Ihnen Unc5c Kits (10) und Unc5c Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 96 products:
Human Polyclonal Unc5c Primary Antibody für ICC, IF - ABIN450081
Shin, Nagasaka, Jung, Matsubara, Kim, Carethers, Boland, Goel: Epigenetic and genetic alterations in Netrin-1 receptors UNC5C and DCC in human colon cancer. in Gastroenterology 2007
we identified ENC1 (zeige ENC1 Antikörper) and UNC5C as genes with convergent genetic, epigenetic, and transcriptomic evidence supporting a potential role in the dissociation of cognition and neuropathology in an aging population.
the results suggest that UNC5C methylation may be an earlier event in the development of colorectal cancer, which was negatively correlated with protein expression.
7 of these 8 variants do not cause increased colorectal cancer risk, including UNC5C c.1882_1883delinsAA (p.A628K).
Data show that overexpression of wild-type netrin receptor UNC5C (UNC5C) causes low-grade death, which is intensified by an Alzheimer Disease-linked mutation T835M, and mediated by amyloid beta precursor protein (APP (zeige APP Antikörper)).
identify the V-2 domain of netrin-1 (zeige NTN1 Antikörper) to be important for its interaction with the Ig1/Ig2 domains of UNC5H2 (zeige UNC5B Antikörper)
we have identified novel frequent somatic mutations of UNC5C in muscle-invasive bladder cancers.
T835M (rs137875858) in the UNC5C wa (zeige CA3 Antikörper)s associated with late-onset Alzheimer disease and increased cell death in HEK293 cells.
UNC5C mutations are very rare in familial and sporadic colorectal carcinomas.
TNM (zeige ODZ1 Antikörper) stage 1 hepatocellular carcinoma (HCC (zeige FAM126A Antikörper)) presented UNC5C methylation, indicating that the UNC5C gene has been methylated from the early stages of HCC (zeige FAM126A Antikörper).
knockdown of DSCAM (zeige DSCAM Antikörper) inhibits netrin-induced tyrosine phosphorylation of UNC5C and Fyn (zeige FYN Antikörper) as well as the interaction of UNC5C with Fyn (zeige FYN Antikörper). The double knockdown of both receptors abolishes the induction of Fyn (zeige FYN Antikörper) tyrosine phosphorylation by netrin-1 (zeige NTN1 Antikörper)
Here, we report that dissociation of UNC5C and polymerized TUBB3 (zeige TUBB3 Antikörper), the highly dynamic beta-tubulin (zeige TUBB Antikörper) isoform in neurons, is essential for netrin-1 (zeige NTN1 Antikörper)/UNC5C-promoted axon repulsion. These results not only provide a working model of direct modulation of MTs (zeige NEU2 Antikörper) by guidance cues in growth cone navigation but also help us to understand molecular mechanisms underlying developmental brain disorders associated with TUBB3 (zeige TUBB3 Antikörper) mutations.
UNC5C expression levels increased from the 4-cell stage to the blastocyst stage in fertilized murine embryos. Repression of UNC5C in the anterior nucleus stage inhibited development to the blastocyst stage.
UNC5c expression is enriched in CA3 (zeige CA3 Antikörper) hippocampal neurons, but UNC5c is not expressed in microglia or perpheral blood mononuclear cells.
Unc5C and DCC (zeige DCC Antikörper) act downstream of Ctip2 (zeige BCL11B Antikörper) and Satb2 (zeige SATB2 Antikörper) and contribute to corpus callosum formation.
unc5c haploinsufficiency results in diminished amphetamine-induced locomotion in male and female mice. This phenotype is identical to that produced by dcc (zeige DCC Antikörper) haploinsufficiency and is observed after adolescence.
this study suggested that Unc5c plays a broad role in dorsal guidance of axons in the developing hindbrain.
These results support an important role for UNC5C in spinal accessory motor neuron development.
repression of Unc5c expression by Rhox5 may, in part, mediate the pro-survival function of Rhox5 in the testis
The netrin-1 receptor UNC5c, a proapoptotic molecule that is inhibited by RHOX5, was also regulated in vivo, and is thus a candidate to be downstream of RHOX5 in a prosurvival germ-cell pathway.
Cows with higher conception rates carried the A+169G polymorphism in the 3' untranslated region of UNC5C (zeige UNC5B Antikörper), which transcripts were expressed at higher levels than those carrying the G polymorphism, which might cause poor preimplantation embryo development.
This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin\; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region.
unc-5 homolog C (C. elegans)
, netrin receptor UNC5C-like
, netrin receptor UNC5C
, protein unc-5 homolog 3
, protein unc-5 homolog C
, unc-5 homolog 3
, unc5 (C.elegans homolog) c
, UNC-5 homolog 3
, rostral cerebellar malformation protein
, unc5 homolog 3
, UNC5-like protein 3