anti-Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 (UHRF1) Antikörper

UHRF1 encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. Zusätzlich bieten wir Ihnen UHRF1 Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
UHRF1 29128 Q96T88
UHRF1 18140 Q8VDF2
UHRF1 316129 Q7TPK1
Direkt bei antikoerper-online bestellen
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Online bestellen
  • orders@antikoerper-online.de

Top anti-UHRF1 Antikörper auf antikoerper-online.de

Showing 10 out of 107 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-UHRF1 Antibody  Positive Control: Lane 1: 60ug HCT116 lysate Lane 2: 60ug HCT116 lysate + siRNA  Primary Antibody Dilution :  1:1000 Secondary Antibody : Anti rabbit-HRP  Secondry Antibody Dilution :  1:5,000 Submitted by: Chinweike Ukomadu, Brigham and Women's Hospital, Boston WB Suggested Anti-UHRF1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: Human Stomach 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert IHC (p), WB Western blot analysis of UHRF1 expression in MCF-7 whole cell lysates (lane 1) and U2OS whole cell lysates (lane 2). UHRF1 at 90KD was detected using rabbit anti- UHRF1 Antigen Affinity purified polyclonal antibody at0.5 μg/mL. The blot was developed using chemiluminescence (ECL) method 100 μg Anmelden zum Anzeigen 4 bis 6 Tage
$240.00
Details
Human Kaninchen Unkonjugiert FACS, IF, WB Western blot analysis of UHRF1 Antibody (Center) (ABIN652792) in Hela cell line lysates (35 µg/lane). UHRF1 (arrow) was detected using the purified polyclonal antibody. UHRF1 Antibody (Center) (ABIN652792) flow cytometry analysis of Hela cells (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Maus Unkonjugiert IF, WB Immunofluorescence of monoclonal antibody to UHRF1 on HeLa cell (antibody concentration 10 µg/mL). UHRF1 monoclonal antibody (M01), clone 3A11 Western Blot analysis of UHRF1 expression in HeLa NE. 0.1 mg Anmelden zum Anzeigen 8 bis 11 Tage
$450.00
Details
Human Kaninchen Unkonjugiert WB Western blot analysis of UHRF1 expression in HeLa (A), HCT116 (B), HEK293 (C) whole cell lysates. 200 μL Anmelden zum Anzeigen 13 bis 14 Tage
$487.50
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), IP, WB Detection of Human NP95//UHRF1 by Western Blot and Immunoprecipitation.  Samples: Whole cell lysate (5, 15 and 50 mcg for WB, 1 mg for IP, 20% of IP loaded) from HeLa cells.  Antibodies: Affinity purified rabbit anti-NP95//UHRF1 antibody ABIN261674 used for WB at 0.04 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 3 mcg/mg lysate.  NP95//UHRF1 was also immunoprecipitated by another rabbit anti-NP95//UHRF1 antibody, which recognizes a downstream epitope.   Detection: Chemiluminescence with exposure times of 3 minutes (A) and 10 seconds (B). Immunohistochemistry-Paraffin: UHRF1 Antibody [ABIN2616747] - FFPE section of human lung carcinoma. Antibody: Affinity purified rabbit anti-NP95/UHRF1 used at a dilution of 1:200 (1ug/ml). Detection: DAB 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$486.94
Details
Human Kaninchen Unkonjugiert ChIP, IF, IP, IHC, WB 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$335.00
Details
Human Maus Unkonjugiert ICC, IF, IP, IHC, WB Uhrf1 antibody (mAb) tested by immunofluorescence. Formaldehyde fixed HeLa cells stained with Uhrf1 antibody at a 0.5 µg/ml dilution. 100 μg Anmelden zum Anzeigen 1 bis 2 Tage
$495.83
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC (p), WB WB Image Sample (30 ug of whole cell lysate) A: HeLa 7.5% SDS PAGE antibody diluted at 1:2000 IHC-P Image Immunohistochemical analysis of paraffin-embedded BT483 xenograft, using UHRF1, antibody at 1:250 dilution. 100 μL Anmelden zum Anzeigen 1 bis 2 Tage
$358.60
Details

UHRF1 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
Human ,
, ,
,
, , , , ,
Mouse (Murine)
, , ,
,
Rat (Rattus)
,

Am meisten referenzierte anti-UHRF1 Antikörper

  1. Human Polyclonal UHRF1 Primary Antibody für ICC, IF - ABIN261674 : Ma, Chen, Guo, Wang, Sowa, Zheng, Hu, Zeng, Guo, Diao, Lan, Harper, Shi, Xu, Shi: M phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability. in Proceedings of the National Academy of Sciences of the United States of America 2012 (PubMed)
    Show all 2 Pubmed References

  2. Human Monoclonal UHRF1 Primary Antibody für ICC, IF - ABIN2668962 : Hopfner, Mousli, Jeltsch, Voulgaris, Lutz, Marin, Bellocq, Oudet, Bronner: ICBP90, a novel human CCAAT binding protein, involved in the regulation of topoisomerase IIalpha expression. in Cancer research 2000 (PubMed)
    Show all 2 Pubmed References

  3. Human Monoclonal UHRF1 Primary Antibody für IF, ELISA - ABIN565416 : Mistry, Gibson, Yun, Sarras, Tamblyn, McPherson: Interplay between Np95 and Eme1 in the DNA damage response. in Biochemical and biophysical research communications 2008 (PubMed)
    Show all 2 Pubmed References

  4. Human Monoclonal UHRF1 Primary Antibody für FM, WB - ABIN968794 : Hopfner, Mousli, Garnier, Redon, du Manoir, Chatton, Ghyselinck, Oudet, Bronner: Genomic structure and chromosomal mapping of the gene coding for ICBP90, a protein involved in the regulation of the topoisomerase IIalpha gene expression. in Gene 2001 (PubMed)
    Show all 2 Pubmed References

Weitere Antikörper gegen UHRF1 Interaktionspartner

Human Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 (UHRF1) Interaktionspartner

  1. Hemi-methylated CpGs DNA recognition activates UHRF1 ubiquitylation towards multiple lysines on the H3 tail adjacent to the UHRF1 histone-binding site.

  2. A histone H3K9-like mimic within LIG1 (zeige LIG1 Antikörper) is methylated by G9a (zeige EHMT2 Antikörper) and GLP (zeige RCBTB1 Antikörper) and avidly binds UHRF1. Interaction with methylated LIG1 (zeige LIG1 Antikörper) promotes the recruitment of UHRF1 to DNA replication sites and is required for DNA methylation (zeige HELLS Antikörper) maintenance.

  3. Down-regulation of UHRF1 is an important mechanism of PIM1 (zeige PIM1 Antikörper)-mediated cellular senescence.

  4. UHRF1 gene expression levels correlates with the major pathological characteristics of transitional cell carcinoma samples and with the clinical outcome of those patients. Determination of UHRF1 gene expression could have a potential to be used as a sensitive molecular marker in patients with urinary bladder cancer.

  5. decreased UHRF1 expression is a key initial event in the suppression of DNMT1 (zeige DNMT1 Antikörper)-mediated DNA methylation (zeige HELLS Antikörper) and in the consequent induction of senescence via increasing WNT5A (zeige WNT5A Antikörper) expression

  6. Our results provide insights into the molecular basis of DNMT1 (zeige DNMT1 Antikörper) dysfunction in hereditary sensory and autonomic neuropathies with dementia and hearing loss patients and emphasize the importance of the TS domain in the regulation of DNA methylation (zeige HELLS Antikörper) in pluripotent and differentiating cells

  7. results identify UHRF1 as a novel HSP90 (zeige HSP90 Antikörper) client protein and shed light on the regulation of UHRF1 stability and function.

  8. Down-regulation of UHRF1 by RNAi inhibited proliferation and clonogenic ability of medullobastoma cell lines with cell cycle arrest in G1/G2-phase. Cells transfected with lenti-shUHRF1 showed increased p16 (zeige CDKN2A Antikörper) expression and location shift of CDK4 (zeige CDK4 Antikörper) in medulloblastoma cells.

  9. Our study uncovered that UHRF1 overexpressed in cervical squamous cell carcinoma and silent UHRF1 gene can reduce tumorigenicity of the CaSki cells by decreasing its proliferation capacity and making it stagnate at G0 and G1 phases as well as accelerating its apoptosis

  10. The overexpression of UHRF1 was correlated with the stage and grade of gastric cancer and is associated with the genotype distribution of MiR (zeige MLXIP Antikörper)-146a rs2910164.

Pig (Porcine) Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 (UHRF1) Interaktionspartner

  1. Data show that the expression levels of the 5 epigenetic modifying genes Dnmt1 (zeige DNMT1 Antikörper), Dnmt3a (zeige DNMT3A Antikörper), Hdac1 (zeige HDAC1 Antikörper), Kdm3a (zeige KDM3A Antikörper) and Uhrf1 were higher in group pig in highland (TH) than in group Yorkshire in highland (YH).

Zebrafish Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 (UHRF1) Interaktionspartner

  1. Dnmt1 (zeige DNMT1 Antikörper) stability requires UHRF1 phosphorylation and that crosstalk between the proteins is essential for the function of these two important epigenetic regulators during gastrulation

  2. DNA hypomethylation is the mechanism underlying the cell cycle block and small liver phenotype caused by uhrf1 depletion.

  3. an essential role for UHRF1 phosphorylation by cyclin-dependent kinase 2 (zeige CDK2 Antikörper)/cyclin A2 (zeige CCNA2 Antikörper) during early vertebrate development

  4. These data provide the first evidence that Uhrf1 and Dnmt1 (zeige DNMT1 Antikörper) function is required for vertebrate lens development and maintenance.

  5. uhrf1 is required for physiologic liver growth in both embryos and adults

Mouse (Murine) Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 (UHRF1) Interaktionspartner

  1. Whole genome bisulfite sequencing revealed that blastocysts derived from KO oocytes have a greatly reduced level of CG methylation, suggesting that maternal UHRF1 is essential for maintaining CG methylation, particularly at the imprinting control regions, in preimplantation embryos.

  2. SETDB1 (zeige SETDB1 Antikörper) maintains silencing of intracisternal A particle, but in the absence of DNMT1 (zeige DNMT1 Antikörper), prolonged binding of NP95 to hemimethylated DNA transiently disrupts SETDB1 (zeige SETDB1 Antikörper)-dependent H3K9me3 deposition.

  3. deletion of Uhrf1 lead to global DNA hypomethylation with a strong activation of the intracisternal A particle (IAP (zeige ALPI Antikörper)) family of endogenous retroviral elements, accompanied by an increase in 5-hydroxymethylcytosine

  4. Our results provide insights into the molecular basis of DNMT1 (zeige DNMT1 Antikörper) dysfunction in hereditary sensory and autonomic neuropathies with dementia and hearing loss patients and emphasize the importance of the TS domain in the regulation of DNA methylation (zeige HELLS Antikörper) in pluripotent and differentiating cells

  5. results identify UHRF1 as a novel HSP90 (zeige HSP90 Antikörper) client protein and shed light on the regulation of UHRF1 stability and function.

  6. Uhrf1 regulation of the Akt (zeige AKT1 Antikörper)-mTOR (zeige FRAP1 Antikörper) signaling pathway is required for invariant natural killer T cell development.

  7. Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its H3 histone (zeige HIST1H3B Antikörper) recognition.

  8. the histone modification status at the DMRs of imprinted genes may dictate whether DNA methylation (zeige HELLS Antikörper) could be restored upon UHRF1 re-expression

  9. UHRF1 is strongly up-regulated during liver regeneration independently of BIRC5 (zeige BIRC5 Antikörper).

  10. report identifies PARP1 (zeige PARP1 Antikörper) as a novel modulator of two UHRF1-regulated heterochromatin-associated events: the accumulation of H4K20me3 and the clearance of DNMT1 (zeige DNMT1 Antikörper)

UHRF1 Antigen-Profil

Protein Überblick

This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. Multiple transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit UHRF1

  • ubiquitin like with PHD and ring finger domains 1 (UHRF1) Antikörper
  • ubiquitin-like, containing PHD and RING finger domains, 1 (Uhrf1) Antikörper
  • ubiquitin-like with PHD and ring finger domains 1 (Uhrf1) Antikörper
  • ubiquitin-like with PHD and ring finger domains 1 (uhrf1) Antikörper
  • ubiquitin like with PHD and ring finger domains 1 (Uhrf1) Antikörper
  • AL022808 Antikörper
  • fb97f09 Antikörper
  • hNP95 Antikörper
  • hUHRF1 Antikörper
  • ICBP90 Antikörper
  • NP95 Antikörper
  • RNF106 Antikörper
  • UHRF1 Antikörper
  • wu:fb97f09 Antikörper
  • zgc:63539 Antikörper

Bezeichner auf Proteinebene für UHRF1

E3 ubiquitin-protein ligase UHRF1 , RING finger protein 106 , huNp95 , inverted CCAAT box-binding protein of 90 kDa , nuclear protein 95 , nuclear zinc finger protein Np95 , transcription factor ICBP90 , ubiquitin-like PHD and RING finger domain-containing protein 1 , ubiquitin-like, containing PHD and RING finger domains, 1 , ubiquitin-like-containing PHD and RING finger domains protein 1 , mUhrf1 , liver regeneration-related protein LRRG126 , ubiquitin-like with PHD and ring finger domains 1

GENE ID SPEZIES
29128 Homo sapiens
18140 Mus musculus
316129 Rattus norvegicus
406350 Danio rerio
420154 Gallus gallus
455613 Pan troglodytes
530411 Bos taurus
611463 Canis lupus familiaris
100062347 Equus caballus
100511003 Sus scrofa
100719542 Cavia porcellus
Ausgewählte Anbieter für anti-UHRF1 (UHRF1) Antikörper
Haben Sie etwas anderes gesucht?