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UHRF1 encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. Zusätzlich bieten wir Ihnen UHRF1 Antikörper (106) und UHRF1 Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.
Results find the overexpression of the anti-apoptotic UHRF1 to coordinate the epigenetic silencing of several tumor suppressor genes in many human haematological and solid cancers causing apoptosis inhibition. [review]
our present data demonstrated that both strands of miR (zeige MLXIP ELISA Kits)-145 (miR (zeige MLXIP ELISA Kits)-145-5p: guide-strand and miR (zeige MLXIP ELISA Kits)-145-3p: passenger-strand) play pivotal roles in bladder cancer cells by regulating UHRF1
The results indicated that globular adiponectin inhibited the prooncogenic effects of leptin (zeige LEP ELISA Kits) via AdipoR2 (zeige ADIPOR2 ELISA Kits)-mediated suppression of UHRF1
Hemi-methylated CpGs DNA recognition activates UHRF1 ubiquitylation towards multiple lysines on the H3 tail adjacent to the UHRF1 histone-binding site.
A histone H3K9-like mimic within LIG1 (zeige LIG1 ELISA Kits) is methylated by G9a (zeige EHMT2 ELISA Kits) and GLP (zeige RCBTB1 ELISA Kits) and avidly binds UHRF1. Interaction with methylated LIG1 (zeige LIG1 ELISA Kits) promotes the recruitment of UHRF1 to DNA replication sites and is required for DNA methylation (zeige HELLS ELISA Kits) maintenance.
Down-regulation of UHRF1 is an important mechanism of PIM1 (zeige PIM1 ELISA Kits)-mediated cellular senescence.
UHRF1 gene expression levels correlates with the major pathological characteristics of transitional cell carcinoma samples and with the clinical outcome of those patients. Determination of UHRF1 gene expression could have a potential to be used as a sensitive molecular marker in patients with urinary bladder cancer.
decreased UHRF1 expression is a key initial event in the suppression of DNMT1 (zeige DNMT1 ELISA Kits)-mediated DNA methylation (zeige HELLS ELISA Kits) and in the consequent induction of senescence via increasing WNT5A (zeige WNT5A ELISA Kits) expression
Our results provide insights into the molecular basis of DNMT1 (zeige DNMT1 ELISA Kits) dysfunction in hereditary sensory and autonomic neuropathies with dementia and hearing loss patients and emphasize the importance of the TS domain in the regulation of DNA methylation (zeige HELLS ELISA Kits) in pluripotent and differentiating cells
results identify UHRF1 as a novel HSP90 (zeige HSP90 ELISA Kits) client protein and shed light on the regulation of UHRF1 stability and function.
UHRF1 ubiquitinates PAF15 at Lys (zeige LYZ ELISA Kits) 15 and Lys (zeige LYZ ELISA Kits) 24 and promotes its binding to PCNA (zeige PCNA ELISA Kits) during late S-phase
Whole genome bisulfite sequencing revealed that blastocysts derived from KO oocytes have a greatly reduced level of CG methylation, suggesting that maternal UHRF1 is essential for maintaining CG methylation, particularly at the imprinting control regions, in preimplantation embryos.
SETDB1 (zeige SETDB1 ELISA Kits) maintains silencing of intracisternal A particle, but in the absence of DNMT1 (zeige DNMT1 ELISA Kits), prolonged binding of NP95 to hemimethylated DNA transiently disrupts SETDB1 (zeige SETDB1 ELISA Kits)-dependent H3K9me3 deposition.
deletion of Uhrf1 lead to global DNA hypomethylation with a strong activation of the intracisternal A particle (IAP (zeige ALPI ELISA Kits)) family of endogenous retroviral elements, accompanied by an increase in 5-hydroxymethylcytosine
Uhrf1 regulation of the Akt (zeige AKT1 ELISA Kits)-mTOR (zeige FRAP1 ELISA Kits) signaling pathway is required for invariant natural killer T cell development.
Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its H3 histone (zeige HIST1H3B ELISA Kits) recognition.
the histone modification status at the DMRs of imprinted genes may dictate whether DNA methylation (zeige HELLS ELISA Kits) could be restored upon UHRF1 re-expression
UHRF1 is strongly up-regulated during liver regeneration independently of BIRC5 (zeige BIRC5 ELISA Kits).
Dnmt1 (zeige DNMT1 ELISA Kits) stability requires UHRF1 phosphorylation and that crosstalk between the proteins is essential for the function of these two important epigenetic regulators during gastrulation
DNA hypomethylation is the mechanism underlying the cell cycle block and small liver phenotype caused by uhrf1 depletion.
an essential role for UHRF1 phosphorylation by cyclin-dependent kinase 2 (zeige CDK2 ELISA Kits)/cyclin A2 (zeige CCNA2 ELISA Kits) during early vertebrate development
These data provide the first evidence that Uhrf1 and Dnmt1 (zeige DNMT1 ELISA Kits) function is required for vertebrate lens development and maintenance.
uhrf1 is required for physiologic liver growth in both embryos and adults
Data show that the expression levels of the 5 epigenetic modifying genes Dnmt1 (zeige DNMT1 ELISA Kits), Dnmt3a (zeige DNMT3A ELISA Kits), Hdac1 (zeige HDAC1 ELISA Kits), Kdm3a (zeige KDM3A ELISA Kits) and Uhrf1 were higher in group pig in highland (TH) than in group Yorkshire in highland (YH).
This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. Multiple transcript variants encoding different isoforms have been found for this gene.
E3 ubiquitin-protein ligase UHRF1
, RING finger protein 106
, inverted CCAAT box-binding protein of 90 kDa
, nuclear protein 95
, nuclear zinc finger protein Np95
, transcription factor ICBP90
, ubiquitin-like PHD and RING finger domain-containing protein 1
, ubiquitin-like, containing PHD and RING finger domains, 1
, ubiquitin-like-containing PHD and RING finger domains protein 1
, liver regeneration-related protein LRRG126
, ubiquitin-like with PHD and ring finger domains 1