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UBE2S encodes a member of the ubiquitin-conjugating enzyme family. Zusätzlich bieten wir Ihnen UBE2S Antikörper (150) und UBE2S Proteine (18) und viele weitere Produktgruppen zu diesem Protein an.
High UBE2S expression is associated with drug resistance in glioblastoma.
RNF8- and Ube2S-dependent Lys11-linkage ubiquitin conjugation plays an important role in regulating DNA damage-induced transcriptional silencing, distinct from the role of Lys63-linkage ubiquitin in the recruitment of DNA damage repair proteins 53BP1 and BRCA1.
Data indicate that UBE2S and APC3 co-regulate the expression level of P21 at G2/M check point via the ubiquitin-proteasome system.
UBE2S is highly expressed in breast cancer
The anaphase-promoting complex/cyclosome C activity in human cells is tuned by the combinatorial use of three E2 ubiquitin-conjugating enzymes, namely UBE2C (zeige UBE2C ELISA Kits), UBE2S, and UBE2D.
Study identified APC (zeige APC ELISA Kits)/C substrates, including the kinase Nek2A (zeige NEK2 ELISA Kits), that require Ube2S for degradation. The reconstitution of Nek2A (zeige NEK2 ELISA Kits)-ubiquitylation revealed that Ube2S does not simply extend a conjugate but instead branches multiple K11-linked chains off the assemblies produced by Ube2C (zeige UBE2C ELISA Kits).
E2-EPF is overexpressed in cervical cancer and associates with tumor growth
These findings reveal deregulation of the oxygen-sensing pathway impinging on the positive feedback mechanism of HIF1-mediated regulation of E2-EPF in papillary renal cell carcinoma.
Linkage-specific ubiquitin chain formation by Ube2S is the result of substrate-assisted catalysis.
K11 specificity is determined by an E2 enzyme, UBE2S/E2-EPF, that elongates ubiquitin chains after the substrates are pre-ubiquitinated by UbcH10 (zeige UBE2C ELISA Kits) or UbcH5 (zeige UBE2D1 ELISA Kits).
Besides its role in fine-tuning the precise level of Sox2 (zeige SOX2 ELISA Kits), Ube2s reinforces the self-renewing and pluripotent state of embryonic stem cells.
alongside their canonical function in protein degradation, Ube2C (zeige UBE2C ELISA Kits) and -S also control the extrusion of the first polar body.
This gene encodes a member of the ubiquitin-conjugating enzyme family. The encoded protein is able to form a thiol ester linkage with ubiquitin in a ubiquitin activating enzyme-dependent manner, a characteristic property of ubiquitin carrier proteins.
ubiquitin-conjugating enzyme E2S
, ubiquitin-conjugating enzyme E2 S
, ubiquitin-conjugating enzyme e2S
, ubiquitin carrier protein S
, ubiquitin-conjugating enzyme E2-24 kD
, ubiquitin-conjugating enzyme E2-24 kDa
, ubiquitin-conjugating enzyme E2-EPF5
, ubiquitin-protein ligase S
, ubiquitin carrier protein
, Ubiquitin carrier protein S-B
, Ubiquitin-protein ligase S-B
, ubiquitin-conjugating enzyme E2 S-B
, ubiquitin-conjugating enzyme E2S, gene 1