anti-Ubiquitin Specific Peptidase 18 (USP18) Antikörper

The protein encoded by USP18 belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. Zusätzlich bieten wir Ihnen USP18 Proteine (4) und USP18 Kits (3) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
USP18 312688  
USP18 11274 Q9UMW8
USP18 24110 Q9WTV6
Direkt bei antikoerper-online bestellen
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Online bestellen
  • orders@antikoerper-online.de

Top anti-USP18 Antikörper auf antikoerper-online.de

Showing 10 out of 30 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB <b>WB Suggested Anti-USP18 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:62500<br><b>Positive Control: </b>Hela cell lysate <b>Sample Type</b>: 2. mouse brain extracts (80ug)<br> <b>Primary Antibody Dilution:</b> 2ug/ml<br> <b>Secondary Antibody</b>: IRDye 800CW goat anti-rabbit from Li-COR Bioscience<br> <b>Secondary Antibody Dilution:</b> 1: 20,000<br> <b>Image Submitted by</b>: Yuzhi Chen<br> University of Arkansas for Medical Science 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Schimpanse Kaninchen Unkonjugiert EIA, WB   0.1 mg Anmelden zum Anzeigen 12 bis 15 Tage
$450.34
Details
Human Kaninchen Unkonjugiert EIA, IF, IHC (p), WB 50 μg Anmelden zum Anzeigen 6 bis 8 Tage
$500.50
Details
Pferd Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$551.83
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC (p), WB IHC-P Image Immunohistochemical analysis of paraffin-embedded human breast cancer, using USP18, antibody at 1:500 dilution. WB Image Sample (30 ug of whole cell lysate) A: IMR32 10% SDS PAGE antibody diluted at 1:1000 100 μL Anmelden zum Anzeigen 1 bis 2 Tage
$358.60
Details
Human Kaninchen Unkonjugiert ELISA, WB Western blot using Affinity Purified anti-UBP43 antibody shows detection of a band ~43 kDa band (arrowhead) believed to be to UBP43 in lysates from HeLa nuclear extracts (lane 1) and whole cell lysates from HeLa (lane 2), A431 (lane 3, Jurkat (Lane 4) and HEK293 (lane 5).  Approximately 18 µg of each lysate was run on a SDS-PAGE and transferred onto nitrocellulose followed by reaction with a 1:500 dilution of anti-UBP43 antibody. Signal was detected using standard techniques. The strong band between the 37kD and 50kD markers is expected to be UBP43. The other bands are probably non-specific. 100 μg Anmelden zum Anzeigen 1 bis 2 Tage
$389.00
Details
Human Kaninchen Unkonjugiert ELISA, WB 50 μg Anmelden zum Anzeigen 2 bis 3 Tage
$446.88
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), WB Immunohistochemistry-Paraffin: USP18 Antibody [NBP1-33675] - Paraffin-embedded Breast ca, using antibody at 1:500 dilution. Western Blot: USP18 Antibody [NBP1-33675] - Analysis of USP18 on IMR32 lysates using NBP1-33675 at a dilution of 1:1000. 30ug whole cell lysate loaded on 10% SDS PAGE gel. 100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$514.63
Details
Human Kaninchen Unkonjugiert IF, IHC (p), ELISA, WB Human Heart (formalin-fixed, paraffin-embedded) stained with USP18 antibody ABIN213754 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$451.00
Details
Human Kaninchen Unkonjugiert IF, IHC, ELISA, WB 0.05 mg Anmelden zum Anzeigen 2 bis 3 Tage
$550.00
Details

USP18 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität
Rat (Rattus)


Human ,
,
,
Mouse (Murine)


Weitere Antikörper gegen USP18 Interaktionspartner

Human Ubiquitin Specific Peptidase 18 (USP18) Interaktionspartner

  1. associates with and deubiquitinates TAK1 (zeige MAP3K7 Antikörper) to protect against hepatic steatosis, insulin (zeige INS Antikörper) resistance, and the inflammatory response

  2. that Ubiquitin-specific peptidase 18 directly bind to BCL2L1 (zeige BCL2L1 Antikörper) and positively regulated its expression in hepatocellular carcinoma cells

  3. These findings add USP18 deficiency to the list of genetic disorders collectively termed type I interferonopathies

  4. We show that IRF-7 (zeige IRF7 Antikörper) siRNA knockdown enhanced LPS (zeige IRF6 Antikörper)-induced IL-10 (zeige IL10 Antikörper) production in human monocyte-derived macrophages, and USP-18 overexpression attenuated LPS (zeige IRF6 Antikörper)-induced production of IL-10 (zeige IL10 Antikörper) in RAW264.7 cells. Quantitative PCR confirmed upregulation of USP18, USP41, IL10 (zeige IL10 Antikörper), and IRF7 (zeige IRF7 Antikörper). An independent cohort confirmed LPS (zeige IRF6 Antikörper) induction of USP41 and IL10 (zeige IL10 Antikörper) genes

  5. results indicated that USP18 modulates the anti-HBV activity of IFN-F via activation of the JAK (zeige JAK3 Antikörper)/STAT (zeige STAT1 Antikörper) signaling pathway in Hepg2.2.15 cells.

  6. USP18's ISG15 (zeige ISG15 Antikörper) specificity is mediated by a small interaction interface.

  7. STAT2 (zeige STAT2 Antikörper) recruits USP18 to the type I IFN receptor subunit IFNAR2 (zeige IFNAR2 Antikörper) via its constitutive membrane-distal STAT2 (zeige STAT2 Antikörper)-binding site.

  8. findings show that multiple inflammatory stimuli can modulate interferon (zeige IFNA Antikörper) stimulated gene expression and thus inhibit hepatocyte interferon (zeige IFNA Antikörper) signaling via USP18 induction

  9. USP18 negatively regulates NF-kappaB (zeige NFKB1 Antikörper) signaling by targeting TAK1 (zeige MAP3K7 Antikörper) and NEMO (zeige IKBKG Antikörper) for deubiquitination through distinct mechanisms.

  10. Data suggest that USP18 (Ubiquitin-like specific protease 18) sensitive cellular functions include activity of the peptide transporters PEPT1 (zeige SLC15A1 Antikörper) and PEPT2 (zeige SLC15A2 Antikörper).

Pig (Porcine) Ubiquitin Specific Peptidase 18 (USP18) Interaktionspartner

  1. These data highlight USP18 as a host restriction factor during innate immune response to porcine respiratory and reproductive syndrome virus.

  2. USP18 is a potential target gene that promotes reduced replication of PRRSV.

  3. Results report identification and cloning of the ISG15 (zeige ISG15 Antikörper) and ISG43 genes in pig.

Mouse (Murine) Ubiquitin Specific Peptidase 18 (USP18) Interaktionspartner

  1. associates with and deubiquitinates TAK1 (zeige NR2C2 Antikörper) to protect against hepatic steatosis, insulin (zeige INS Antikörper) resistance, and the inflammatory response

  2. this study identifies the osteopenia phenotype of mice lacking Usp18, which is known as a negative regulator of type I IFN signaling

  3. USP18 has a protective role in pathological cardiac remodeling in mouse.

  4. USP18's ISG15 (zeige ISG15 Antikörper) specificity is mediated by a small interaction interface.

  5. findings show that multiple inflammatory stimuli can modulate interferon (zeige IFNA Antikörper) stimulated gene expression and thus inhibit hepatocyte interferon (zeige IFNA Antikörper) signaling via USP18 induction

  6. Increased ISGylation was accompanied by enhanced viral resistance without causing detrimental side effects suggesting that USP18 protease inhibition might be a suitable antiviral strategy

  7. USP18 null mice develop leiomyosarcoma recapitulating key features of clinical leiomyosarcomas and patients with reduced-USP18 tumor levels have an unfavorable outcome.

  8. USP18 lack in microglia causes destructive interferonopathy of the mouse brain.

  9. results suggest that increasing ISGylation by specific inhibition of USP18 protease activity could constitute a promising antiviral strategy with only a minimal risk of severe adverse effects

  10. USP18 is crucial for IFN-gamma (zeige IFNG Antikörper)-mediated inhibition of B16 melanoma tumorigenesis and antitumor immunity.

USP18 Antigen-Profil

Protein Überblick

The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon, suggesting a function of this protein in downregulating interferon responses, independent of its isopeptidase activity towards ISG15.

Genbezeichner und Symbole assoziert mit USP18

  • ubiquitin specific peptidase 18 (Usp18) Antikörper
  • ubiquitin specific peptidase 18 (USP18) Antikörper
  • universal stress protein UspA (RR_RS19770) Antikörper
  • 1110058H21Rik Antikörper
  • AW047653 Antikörper
  • bubp43 Antikörper
  • ISG43 Antikörper
  • UBP Antikörper
  • Ubp15 Antikörper
  • UBP43 Antikörper
  • USP18 Antikörper
  • USP41 Antikörper

Bezeichner auf Proteinebene für USP18

ubl carboxyl-terminal hydrolase 18 , ubiquitin specific peptidase 18 , universal stress protein , ubiquitin specific protease 18 , ubiquitin specific peptidase 41 , 43 kDa ISG15-specific protease , ISG15-specific-processing protease , hUBP43 , ubl thioesterase 18 , ubl thiolesterase 18 , interferon-stimulated gene 43 , ubiquitin-specific protease 18 , ubiquitin specific protease 15

GENE ID SPEZIES
312688 Rattus norvegicus
486763 Canis lupus familiaris
515202 Bos taurus
3128094 Haloarcula marismortui ATCC 43049
418167 Gallus gallus
100054488 Equus caballus
100583021 Nomascus leucogenys
11274 Homo sapiens
742929 Pan troglodytes
100171781 Pongo abelii
396777 Sus scrofa
24110 Mus musculus
Ausgewählte Anbieter für anti-USP18 (USP18) Antikörper
Haben Sie etwas anderes gesucht?