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USP14 encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. Zusätzlich bieten wir Ihnen USP14 Proteine (15) und USP14 Kits (5) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 88 products:
Human Polyclonal USP14 Primary Antibody für WB - ABIN1881985
Chen, Qin, Li, Walters, Wilson, Mei, Wilson: The proteasome-associated deubiquitinating enzyme Usp14 is essential for the maintenance of synaptic ubiquitin levels and the development of neuromuscular junctions. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2009
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Human Monoclonal USP14 Primary Antibody für WB - ABIN1882288
Reuter, Medhurst, Waisfisz, Zhi, Herterich, Hoehn, Gross, Joenje, Hoatlin, Mathew, Huber: Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport. in Experimental cell research 2003
Show all 3 Pubmed References
Human Monoclonal USP14 Primary Antibody für IF, ELISA - ABIN563939
Hyrskyluoto, Bruelle, Lundh, Do, Kivinen, Rappou, Reijonen, Waltimo, Petersén, Lindholm, Korhonen: Ubiquitin-specific protease-14 reduces cellular aggregates and protects against mutant huntingtin-induced cell degeneration: involvement of the proteasome and ER stress-activated kinase IRE1?. in Human molecular genetics 2014
Human Polyclonal USP14 Primary Antibody für IHC (p), WB - ABIN388902
Mines, Goodwin, Limbird, Cui, Fan: Deubiquitination of CXCR4 by USP14 is critical for both CXCL12-induced CXCR4 degradation and chemotaxis but not ERK ativation. in The Journal of biological chemistry 2009
These findings suggested that USP14 induces NF-kappaB (zeige NFKB1 Antikörper) activity and ERK1/2 (zeige MAPK1/3 Antikörper) phosphorylation triggered by microbial infection.
Ubiquitin-specific protease 14 regulates cell proliferation and apoptosis in oral squamous cell carcinoma
our report demonstrates significant value in targeting USP14/UCHL5 (zeige UCHL5 Antikörper) with VLX1570 in drug-resistant Waldenstrom macroglobulinemia (WM) and carries a high potential for clinical translation
USP14 promotes prostate cancer progression.
without a ubiquitinated substrate present, Usp14 suppresses multiple proteasomal activities, especially basal ATP consumption and degradation of non-ubiquitinated proteins. These allosteric effects thus reduce ATP hydrolysis by inactive proteasomes and nonspecific proteolysis and enhance proteasomal specificity for ubiquitinated proteins.
USP14 regulates autophagy by negatively controlling K63 ubiquitination of Beclin 1 (zeige BECN1 Antikörper)
USP14 plays an important role in the progression and metastasis of esophageal squamous cell carcinoma.
USP14 participates in CAM-DR of MM through acting as a bridge between Bcl-xl (zeige BCL2L1 Antikörper) apoptotic pathway and Wnt (zeige WNT2 Antikörper)-signaling pathways and may be represented as a good candidate for pursuing clinical trials in MM.
Results show that USP14 mRNA is overexpressed in hepatocellular carcinoma (HCC (zeige FAM126A Antikörper)) tissues and inversely correlates with miR (zeige MLXIP Antikörper)-4782-3p level which binds to USP14 3'UTR (zeige UTS2R Antikörper) to regulate its expression.
Results found USP14 amplification and overexpression in many different cancers. Its overexpression in low-expression cell lines promoted cell proliferation and migration, whereas its downregulation suppressed tumor cell proliferation, increased apoptosis rate, and decreased cell migration and invasion suggesting an oncogenic role in various types of cancer.
USP14's catalytic activity is required for nervous system structure and function and has an ongoing role in NMJ synaptic transmission. USP14 regulation of the ubiquitination status of protein kinases, coordinates NMJ intracellular signaling pathways.
Overexpression of the Usp14 reduces cellular aggregates in mutant Htt-expressing cells mainly via the ubiquitin proteasome system.
USP14 modulates hippocampal short-term plasticity and vesicle number independent of its deubiquitinating activity.
Differences in genetic background were shown to affect ubiquitin expression and dramatically alter the phenotypes caused by USP14 deficiency.
Data indicate that increased levels of phosphorylated tau correlated with the onset of axonal varicosities in the ubiquitin-specific protease 14 (Usp14)-deficient mice.
miR-124 promotes neuronal survival under ischemic conditions via Usp14-dependent REST degradation.
overexpression of HA-USP14 increased TNFalpha (zeige TNF Antikörper)
Oxidative stress increasd USP14 expression, and beta-carotene dose-dependently inhibited increased expression in mouse skeletal muscle myotubes.
This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
deubiquitinating enzyme 14
, tRNA-guanine transglycosylase, 60-kD subunit
, ubiquitin carboxyl-terminal hydrolase 14
, ubiquitin specific protease 14 (tRNA-guanine transglycosylase)
, ubiquitin thioesterase 14
, ubiquitin thiolesterase 14
, ubiquitin-specific processing protease 14
, ubiquitin-specific-processing protease 14
, ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
, ubiquitin domain-containing protein
, dUB-type TGT for deubiquitinating enzyme
, ubiquitin specific protease 14
, universal stress protein
, queuine tRNA-ribosyltransferase
, ubiquitin carboxyl-terminal hydrolase 14-like