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Ubiquitin Specific Peptidase 1 Proteine (USP1)

USP1 encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. Zusätzlich bieten wir Ihnen USP1 Antikörper (95) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
USP1 7398 O94782
Maus USP1 USP1 230484 Q8BJQ2
USP1 313387 Q569C3
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Showing 6 out of 6 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 66 Days
10.536,00 €
Details
HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
Details
Hefe Fungus His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.056,83 €
Details
Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
4.096,19 €
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
748,00 €
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HOST_Escherichia coli (E. coli) Ratte T7 tag,His tag   100 μg Anmelden zum Anzeigen 13 bis 17 Tage
670,48 €
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USP1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Rat (Rattus) ,
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Weitere Proteine zu Ubiquitin Specific Peptidase 1 (USP1) Interaktionspartnern

Human Ubiquitin Specific Peptidase 1 (USP1) Interaktionspartner

  1. High USP1 expression is associated with glioma.

  2. USP1-UAF1 (zeige WDR48 Proteine) complex promotes homologous recombination repair via multiple mechanisms: through FANCD2 deubiquitination, as well as by interacting with RAD51AP1 (zeige RAD51AP1 Proteine).

  3. The results suggest that silencing USP1 inhibits cell proliferation and invasion in U2OS cells. Therefore, USP1 may provide a novel therapeutic target for the treatment of osteosarcoma.

  4. Translational regulation of the mRNA encoding USP1 is involved in the DNA damage response as a determinant of cisplatin resistance.

  5. Ubiquitination-specific proteases 1 (USP1)-mediated protein stabilization promotes glioblastoma (GBM) stem-like cells maintenance and treatment resistance, thereby providing a rationale for USP1 inhibition as a potential therapeutic approach against GBM.

  6. analysis of the function and regulation of the USP1-UAF1 (zeige WDR48 Proteine) complex

  7. USP1, p21 and Spartan are translesion DNA synthesis regulators. (Review)

  8. No correlation was observed between the protein level of ubiquitin-specific protease 1 (USP1) and ubiquitinated PCNA (zeige PCNA Proteine) in BAF180 (zeige PBRM1 Proteine) expressing cells

  9. USP1 phosphorylation at S313 is not critical for PCNA (zeige PCNA Proteine) deubiquitination, neither for binding to UAF1 (zeige WDR48 Proteine) in a cellular environment.

  10. Coimmunoprecipitation experiments indicated that human papillomavirus type 31 E1 assembles into a ternary complex with UAF1 (zeige WDR48 Proteine) and any one of these three USPs: USP1, USP12 (zeige USP12 Proteine) and USP46 (zeige USP46 Proteine).

Mouse (Murine) Ubiquitin Specific Peptidase 1 (USP1) Interaktionspartner

  1. our results strongly suggest that Usp1 is involved in the regulation of centrosome duplication, at least in part via ID1 (zeige ID1 Proteine), and Usp1 may exert its oncogenic activity, partially through inducing centrosome abnormality.

  2. Data suggest Usp1 down-regulation by autocleavage is critical for Usp1 to exert role in DNA interstrand crosslink repair; Usp1 role is de-ubiquitination of Fancd2 (Fanconi anemia complementation group D2) and Pcna (proliferating cell nuclear antigen (zeige PCNA Proteine)).

  3. Homozygous Uaf1 (zeige WDR48 Proteine)(-/-) embryos died at embryonic day 7.5 (E7.5). These mutant embryos were small and developmentally retarded.

  4. Autocleaved Usp1 remains a deubiquitylase because its fragments remain associated with Uaf1, an enhancer of Usp1 activity, until the C-terminal fragment is selectively destroyed by the Arg/N-end rule pathway.

  5. Bone marrow from Fancd2-/- mice and Usp1-/- mice exhibited marked hematopoietic defects.

  6. mouse Usp1 functions downstream in the Fanconi anemia pathway, and its deubiquitination is required for Fancd2 nuclear foci assembly

USP1 Protein Überblick

Protein Überblick

This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. The protein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice variants have been characterized.

Genbezeichner und Symbole assoziert mit USP1

  • ubiquitin specific peptidase 1 (USP1)
  • ubiquitin specific peptidase 1 (usp1)
  • ubiquitin specific peptidase 1 (Usp1)
  • UBP Protein
  • usp1-a Protein

Bezeichner auf Proteinebene für USP1

ubiquitin carboxyl-terminal hydrolase 1 , ubiquitin specific protease 1 , ubiquitin specific peptidase 1 , ubiquitin carboxyl-terminal hydrolase 1-like , deubiquitinating enzyme 1 , hUBP , ubiquitin carboxyl terminal hydrolase 1 , ubiquitin specific processing protease 1 , ubiquitin thioesterase 1 , ubiquitin thiolesterase 1 , ubiquitin-specific-processing protease 1 , ubiquitin specific peptdiase 1

GENE ID SPEZIES
100070397 Equus caballus
447465 Xenopus laevis
456901 Pan troglodytes
695157 Macaca mulatta
100443075 Pongo abelii
7398 Homo sapiens
230484 Mus musculus
313387 Rattus norvegicus
424685 Gallus gallus
479549 Canis lupus familiaris
100523071 Sus scrofa
516328 Bos taurus
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