anti-Ubiquitin Associated and SH3 Domain Containing, A (UBASH3A) Antikörper

UBASH3A encodes one of two family members belonging to the T-cell ubiquitin ligand (TULA) family. Zusätzlich bieten wir Ihnen Ubiquitin Associated and SH3 Domain Containing, A Proteine (6) und und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
UBASH3A 53347 P57075
UBASH3A 328795 Q3V3E1
UBASH3A 309666  
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Showing 10 out of 82 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
Details
Human Ziege Unkonjugiert IHC, ELISA, WB ABIN190877 (2.5µg/ml) staining of paraffin embedded Human Spleen. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. 100 μg Anmelden zum Anzeigen 3 bis 4 Tage
349,82 €
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Human Ziege Unkonjugiert IHC (p), IHC, ELISA ABIN252907 (2.5ug/ml) staining of paraffin embedded Human Spleen. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. 0.1 mg Anmelden zum Anzeigen 2 bis 4 Tage
311,00 €
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Fledermaus Ziege Unkonjugiert IHC (p), ELISA Human Spleen (formalin-fixed, paraffin-embedded) stained with UBASH3A antibody ABIN290205 at 2.5 ug/ml followed by biotinylated anti-goat IgG secondary antibody ABIN481715, alkaline phosphatase-streptavidin and chromogen. 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
501,70 €
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Rind (Kuh) Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
653,02 €
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Human Ziege Unkonjugiert ELISA, IHC, WB   100 μg Anmelden zum Anzeigen 3 bis 4 Tage
349,82 €
Details
Human Kaninchen Unkonjugiert ELISA, WB   100 μg Anmelden zum Anzeigen 6 bis 8 Tage
342,86 €
Details
Human Ziege Unkonjugiert ELISA, WB 0.1 mg Anmelden zum Anzeigen 6 bis 8 Tage
505,48 €
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Human Ziege Unkonjugiert IHC (p), ELISA, WB 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
501,70 €
Details
Human Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 11 bis 14 Tage
600,64 €
Details

UBASH3A Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
Human ,
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Mouse (Murine)


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Rat (Rattus)


Am meisten referenzierte anti-Ubiquitin Associated and SH3 Domain Containing, A Antikörper

  1. Human Polyclonal UBASH3A Primary Antibody für IHC (p), IHC - ABIN252907 : Kowanetz, Crosetto, Haglund, Schmidt, Heldin, Dikic: Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases. in The Journal of biological chemistry 2004 (PubMed)

Weitere Antikörper gegen Ubiquitin Associated and SH3 Domain Containing, A Interaktionspartner

Human Ubiquitin Associated and SH3 Domain Containing, A (UBASH3A) Interaktionspartner

  1. UBASH3A attenuates the NF-kappaB signal transduction upon T-cell receptor (TCR) stimulation by specifically suppressing the activation of the IkappaB kinase complex. UBASH3A interacts with TAK1 and NEMO, suggesting that UBASH3A regulates the NF-kappaB signaling pathway by an ubiquitin-dependent mechanism. T1D risk alleles at rs11203203 and rs80054410 increase UBASH3A expression in CD4(+) T cells upon TCR stimulation.

  2. A negative correlation was found between UBASH3A mRNA expression and systemic lupus erythematosus.

  3. Findings suggest that UBASH3A gene might contribute to systemic lupus erythematosus susceptibility and influence the clinical phenotype of the disease.

  4. Addition of PTPN22 (zeige PTPN22 Antikörper) and UBASH3A SNPs to HLA-DR,DQ genotyping can improve type 1 diabetes risk prediction.

  5. Results suggest that UBASH3a gene plays a role in the susceptibility to systemic lupus erythematosus and UBASH3a can be considered as a common genetic factor in autoimmune diseases.

  6. ubiquitin associated and SH3 domain containing A appears to be an independent predictor of islet autoimmunity and type 1 diabetes in children, including those free of family history of T1D but carrying the HLA-DR3/4,DQB1*0302 genotype

  7. The UBASH3A promoter is activated by serum depletion according to promoter reporter assays in HEK (zeige EPHA3 Antikörper) 293 cells.

  8. Sts-1 (zeige STS1 Antikörper) and Sts-2 bind to Cbl (zeige CBL Antikörper) and inhibit endocytosis of receptor tyrosine kinases

  9. TULA inhibits both clathrin-dependent and clathrin-independent endocytic pathways by functionally sequestering dynamin (zeige DNM1 Antikörper) via the SH3 domain (zeige ITSN1 Antikörper) of TULA binding proline-rich sequences in dynamin (zeige DNM1 Antikörper)

  10. TULA enhances the apoptotic effect of AIF (zeige AIFM1 Antikörper) by facilitating the interactions of AIF (zeige AIFM1 Antikörper) with its apoptotic co-factors

Mouse (Murine) Ubiquitin Associated and SH3 Domain Containing, A (UBASH3A) Interaktionspartner

  1. Herein, the authors demonstrate that mice lacking Sts (zeige STS Antikörper) expression are significantly resistant to infection by the live vaccine strain of Francisella tularensis.

  2. Sts-1 (zeige STS1 Antikörper) and Sts-2 are not required for the immune control of murine herpesvirus 68 in a normal course of gammaherpesvirus infection.

  3. Biochemical analysis identified STS-1 (zeige STS1 Antikörper) and STS-2 as direct phosphatases of FLT3 (zeige FLT3 Antikörper) and c-KIT (zeige KIT Antikörper).

  4. The lack of TULA facilitates T-cell responses to TCR/CD3 (zeige CD3E Antikörper) stimulation, thus exacerbating T-cell-dependent inflammation.

  5. Skeletal analysis of mice that do not express TULA or TULA-2 (zeige STS1 Antikörper) proteins (DKO mice) revealed that there was a decrease in bone volume due to increased osteoclast numbers and function.

  6. Sts-2 is a phosphatase that negatively regulates zeta-associated protein (ZAP)-70 (zeige ZAP70 Antikörper) and T cell receptor signaling pathways.

  7. Sts-2(phosphoglycerate mutase) adopts the conformation of an active phosphatase whose activity is fundamentally different from that of Sts-1 (zeige STS1 Antikörper) despite the strong structural homology.

  8. the crystal structure of Sts-2(PGM (zeige Vcan Antikörper)) in the phosphorylated active form and bound to VO(3)

  9. The Sts-1,2 proteins target tyrosine phosphorylated, ubiquitinated proteins within TCR signaling pathways.

Ubiquitin Associated and SH3 Domain Containing, A (UBASH3A) Antigen-Profil

Protein Überblick

This gene encodes one of two family members belonging to the T-cell ubiquitin ligand (TULA) family. Both family members can negatively regulate T-cell signaling. This family member can facilitate growth factor withdrawal-induced apoptosis in T cells, which may occur via its interaction with AIF, an apoptosis-inducing factor. Alternative splicing of this gene results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit UBASH3A

  • ubiquitin associated and SH3 domain containing, A (UBASH3A) Antikörper
  • ubiquitin associated and SH3 domain containing A (UBASH3A) Antikörper
  • ubiquitin associated and SH3 domain containing, A (Ubash3a) Antikörper
  • 5830413C03Rik Antikörper
  • C330001M22 Antikörper
  • CLIP4 Antikörper
  • Sts-2 Antikörper
  • TULA Antikörper
  • TULA-1 Antikörper
  • UBASH3A Antikörper

Bezeichner auf Proteinebene für UBASH3A

ubiquitin associated and SH3 domain containing, A , T-cell ubiquitin ligand 1 , T-cell ubiquitin ligand protein , cbl-interacting protein 4 , suppressor of T-cell receptor signaling 2 , ubiquitin-associated and SH3 domain-containing protein A

GENE ID SPEZIES
418535 Gallus gallus
474125 Pan troglodytes
53347 Homo sapiens
487779 Canis lupus familiaris
514555 Bos taurus
328795 Mus musculus
309666 Rattus norvegicus
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