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UBASH3A encodes one of two family members belonging to the T-cell ubiquitin ligand (TULA) family. Zusätzlich bieten wir Ihnen Ubiquitin Associated and SH3 Domain Containing, A Proteine (6) und und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal UBASH3A Primary Antibody für IHC (p), IHC - ABIN252907
Kowanetz, Crosetto, Haglund, Schmidt, Heldin, Dikic: Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases. in The Journal of biological chemistry 2004
UBASH3A attenuates the NF-kappaB signal transduction upon T-cell receptor (TCR) stimulation by specifically suppressing the activation of the IkappaB kinase complex. UBASH3A interacts with TAK1 and NEMO, suggesting that UBASH3A regulates the NF-kappaB signaling pathway by an ubiquitin-dependent mechanism. T1D risk alleles at rs11203203 and rs80054410 increase UBASH3A expression in CD4(+) T cells upon TCR stimulation.
A negative correlation was found between UBASH3A mRNA expression and systemic lupus erythematosus.
Findings suggest that UBASH3A gene might contribute to systemic lupus erythematosus susceptibility and influence the clinical phenotype of the disease.
Addition of PTPN22 (zeige PTPN22 Antikörper) and UBASH3A SNPs to HLA-DR,DQ genotyping can improve type 1 diabetes risk prediction.
Results suggest that UBASH3a gene plays a role in the susceptibility to systemic lupus erythematosus and UBASH3a can be considered as a common genetic factor in autoimmune diseases.
ubiquitin associated and SH3 domain containing A appears to be an independent predictor of islet autoimmunity and type 1 diabetes in children, including those free of family history of T1D but carrying the HLA-DR3/4,DQB1*0302 genotype
The UBASH3A promoter is activated by serum depletion according to promoter reporter assays in HEK (zeige EPHA3 Antikörper) 293 cells.
Sts-1 (zeige STS1 Antikörper) and Sts-2 bind to Cbl (zeige CBL Antikörper) and inhibit endocytosis of receptor tyrosine kinases
TULA inhibits both clathrin-dependent and clathrin-independent endocytic pathways by functionally sequestering dynamin (zeige DNM1 Antikörper) via the SH3 domain (zeige ITSN1 Antikörper) of TULA binding proline-rich sequences in dynamin (zeige DNM1 Antikörper)
TULA enhances the apoptotic effect of AIF (zeige AIFM1 Antikörper) by facilitating the interactions of AIF (zeige AIFM1 Antikörper) with its apoptotic co-factors
Herein, the authors demonstrate that mice lacking Sts (zeige STS Antikörper) expression are significantly resistant to infection by the live vaccine strain of Francisella tularensis.
Sts-1 (zeige STS1 Antikörper) and Sts-2 are not required for the immune control of murine herpesvirus 68 in a normal course of gammaherpesvirus infection.
Biochemical analysis identified STS-1 (zeige STS1 Antikörper) and STS-2 as direct phosphatases of FLT3 (zeige FLT3 Antikörper) and c-KIT (zeige KIT Antikörper).
The lack of TULA facilitates T-cell responses to TCR/CD3 (zeige CD3E Antikörper) stimulation, thus exacerbating T-cell-dependent inflammation.
Skeletal analysis of mice that do not express TULA or TULA-2 (zeige STS1 Antikörper) proteins (DKO mice) revealed that there was a decrease in bone volume due to increased osteoclast numbers and function.
Sts-2 is a phosphatase that negatively regulates zeta-associated protein (ZAP)-70 (zeige ZAP70 Antikörper) and T cell receptor signaling pathways.
Sts-2(phosphoglycerate mutase) adopts the conformation of an active phosphatase whose activity is fundamentally different from that of Sts-1 (zeige STS1 Antikörper) despite the strong structural homology.
the crystal structure of Sts-2(PGM (zeige Vcan Antikörper)) in the phosphorylated active form and bound to VO(3)
The Sts-1,2 proteins target tyrosine phosphorylated, ubiquitinated proteins within TCR signaling pathways.
This gene encodes one of two family members belonging to the T-cell ubiquitin ligand (TULA) family. Both family members can negatively regulate T-cell signaling. This family member can facilitate growth factor withdrawal-induced apoptosis in T cells, which may occur via its interaction with AIF, an apoptosis-inducing factor. Alternative splicing of this gene results in multiple transcript variants.
ubiquitin associated and SH3 domain containing, A
, T-cell ubiquitin ligand 1
, T-cell ubiquitin ligand protein
, cbl-interacting protein 4
, suppressor of T-cell receptor signaling 2
, ubiquitin-associated and SH3 domain-containing protein A