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The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1\; MIM 601912) is required for numerous biologic processes. Zusätzlich bieten wir Ihnen ULP1 Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.
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The present study examined dynamic changes in SENP3 expression in the cerebral cortex and in its cellular localization.
The p53 (zeige TP53 Antikörper)-independent tumor suppressive functions of p19(Arf (zeige CDKN2A Antikörper)) may be mediated by its ability to antagonize Senp3, thereby inducing cell cycle arrest by abnormally elevating the cellular levels of SUMOylated proteins.
SENP3 knockdown reduced cadmium-induced caspase 3 (zeige CASP3 Antikörper) cleavage and cell death in PC12 cells, while SENP3 overexpression enhanced cell death.
Our data identified SUMOylation as a previously undescribed post-translational modification of STAT3 (zeige STAT3 Antikörper) and SENP3 as a critical positive modulator of tobacco- or cytokine-induced STAT3 (zeige STAT3 Antikörper) activation.
The data demonstrate that SUMO2 (zeige SUMO2 Antikörper) conjugation and SENP3-driven deSUMOylation of PELP1 (zeige PELP1 Antikörper) is instrumental for ordered progression of ribosome maturation, and they provide molecular insight into the dynamics of ribosome maturation.
our findings for the first time specifically supported that SUMO-specific protease 3 might play an important role in the regulation of epithelial ovarian cancer progression and could serve as a potential biomarker for prognosis as well as provide a promising therapeutic target against epithelial ovarian cancer
In early-onset pre-eclampsia, enhanced deSUMOylation of HIF1A (zeige HIF1A Antikörper) by SENP3 may in part contribute to increased HIF1A (zeige HIF1A Antikörper) activity and stability found in this pathology.
High SENP3 expression is associated with stomach neoplasms.
SENP3, which is increased in gastric cancer cells, potentiates the transcriptional activity of FOXC2 (zeige FOXC2 Antikörper) through de-SUMOylation, in favor of the induction of specific mesenchymal gene expression in gastric cancer metastasis.
Evidence show that mTOR (zeige FRAP1 Antikörper)-mediated phosphorylation of SENP3 facilitates the interaction with NPM1 (zeige NPM1 Antikörper), thereby promoting nucleolar targeting.
SENP3 is associated with MLL1/MLL2 (zeige MLL2 Antikörper) complexes and catalyzes deSUMOylation of RbBP5 (zeige RBBP5 Antikörper).
ROS (zeige ROS1 Antikörper) induced SENP3 redistribution from the nucleoli to the nucleoplasm.
The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1\; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP3, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006
SUMO-1-specific protease 3
, SUMO/sentrin specific protease 3
, sentrin-specific protease 3
, sentrin/SUMO-specific protease SENP3
, smt3-specific isopeptidase 1
, sentrin/SUMO-specific protease 3
, SUMO/sentrin specific peptidase 3