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U2AF1 belongs to the splicing factor SR family of genes. Zusätzlich bieten wir Ihnen U2AF1 Antikörper (47) und U2AF1 Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.
The U2AF35(S34F) mutation alters interaction with CFIm59 (zeige CPSF7 ELISA Kits), leading to increased use of a distal cleavage and polyadenylation site in the ATG7 (zeige ATG7 ELISA Kits) pre-mRNA, decreasing levels of ATG7 (zeige ATG7 ELISA Kits) protein and defective autophagy, ultimately leading to transformation.
data support the impact of genes from the Abcg1-U2af1 region as modifiers of Tc1-dependent memory and locomotor phenotypes in Tc1 mouse model of Down syndrome.
findings support the hypothesis that mutant U2AF1 alters downstream gene isoform expression, thereby contributing to abnormal hematopoiesis in patients with MDS (zeige MECOM ELISA Kits)
this study establishes definitely the contribution of the Abcg1 (zeige ABCG1 ELISA Kits)-U2af1 orthologous region to the DS etiology and suggests new modulatory pathways for learning and memory.
infer that U2AF1 S34 mutations characterize a distinct subgroup of myelodysplastic syndrome
Alternative splicing of U2AF1 reveals a shared repression mechanism for duplicated exons controlled by SRF3.
Our results provide mechanistic explanations of the magnitude of splicing changes observed in U2AF1-mutant cells and why tumors harboring U2AF1 mutations always retain an expressed copy of the wild-type allele
Mutations in ASXL1 (zeige ASXL1 ELISA Kits), U2AF1, and SF3B1 are common in Chinese patients with myelodysplastic syndromes.
in primary myelofibrosis, anemia was significantly associated with U2AF1 mutation; study confirms previous observation regarding the association of mutant U2AF1 with anemia supporting its role in hematopoiesis and in the pathogenesis of PMF (zeige PRB1 ELISA Kits)-associated anemia
In multivariate analysis, U2AF1 and TP53 (zeige TP53 ELISA Kits) mutations retained independent prognostic significance across 93 cases of acute myeloid leukemia (zeige BCL11A ELISA Kits)
The mutational status of the SRSF2 (zeige SRSF2 ELISA Kits), U2AF1 and ZRSR2 (zeige ZRSR2 ELISA Kits) did not affect the response rate or survival in MDS (zeige PAFAH1B1 ELISA Kits) patients who had received first-line decitabine treatment.
A mutant U2AF1 (S34F) found in a variety of cancer types results in delayed splicing and disruption of kinetic competition during transcription.
The S34F mutation alters U2AF1 function in the context of specific RNA sequences, leading to aberrant alternative splicing of target genes, some of which may be relevant for myelodysplastic syndromes pathogenesis.
This gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. Alternatively spliced transcript variants encoding different isoforms have been identified.
U2 small nuclear RNA auxiliary factor 1
, RNA recognition motif-containing protein RRM
, RNA-binding region RNP-1 domain-containing protein
, U2 snRNP auxiliary factor small subunit
, U2(RNU2) small nuclear RNA auxiliary factor 1
, U2 auxiliary factor 35 kDa subunit
, U2 small nuclear ribonucleoprotein auxiliary factor (U2AF),35 kDa
, splicing factor U2AF 35 kDa subunit
, U2 small nuclear RNA auxillary factor 1
, U2 small nuclear ribonucleoprotein auxillary factor, 35-KD subunit
, U2(RNU2) small nuclear RNA auxiliary factor binding protein
, splicing factor U2AF 35kDa subunit
, U2snRNP auxiliary factor small subunit
, uncharacterized protein LOC687575
, U2(RNU2) small nuclear RNA auxillary factor 1