anti-Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22) Antikörper

PTPN22 encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. Zusätzlich bieten wir Ihnen PTPN22 Proteine (6) und PTPN22 Kits (1) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
PTPN22 19260 P29352
PTPN22 26191 Q9Y2R2
PTPN22 295338  
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Top anti-PTPN22 Antikörper auf antikoerper-online.de

Showing 10 out of 65 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert WB 100 μg Anmelden zum Anzeigen 4 bis 6 Tage
$240.00
Details
Human Kaninchen Unkonjugiert EIA, WB Western blot analysis in NCI-H460 cell line lysates (35ug/lane) using PTPN22  Antibody (C-term). This demonstrates the PTPN22 antibody detected the PTPN22 protein (arrow). 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Hund Kaninchen Unkonjugiert WB Host: Rabbit Target Name: PTPN22 Sample Type: Thyroid Tumor lysates Antibody Dilution: 1.0ug/ml 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Ziege Unkonjugiert IHC (p) Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Anmelden zum Anzeigen 6 bis 8 Tage
$368.50
Details
Human Maus Unkonjugiert EIA, IHC (p), WB 50 μg Anmelden zum Anzeigen 6 bis 8 Tage
$412.50
Details
Human Maus Unkonjugiert WB Western Blot analysis of PTPN22 expression in transfected 293T cell line by PTPN22 MaxPab polyclonal antibody.<br><br>Lane1:PTPN22 transfected lysate(82.72 KDa).<br>Lane2:Non-transfected lysate.<br> 50 μL Anmelden zum Anzeigen 11 bis 12 Tage
$440.00
Details
Human Kaninchen Unkonjugiert WB PTPN22 Antibody (C-term)  western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the PTPN22 antibody detected the PTPN22 protein (arrow). 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Ziege Unkonjugiert IHC (p) Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Thyroid: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$451.00
Details
Human Kaninchen Unkonjugiert IHC, WB 100 μL Anmelden zum Anzeigen 16 Days
$334.02
Details
Human Maus Unkonjugiert WB Western blot analysis of PTPN22 over-expressed 293 cell line, cotransfected with PTPN22 Validated Chimera RNAi used as specificity and loading control. Western Blot analysis of PTPN22 expression in transfected 293T cell line by PTPN22 monoclonal antibody (M01), clone 4F6. Lane 1: PTPN22 transfected lysate(85.1 KDa). Lane 2: Non-transfected lysate. 0.1 mg Anmelden zum Anzeigen 8 bis 11 Tage
$450.00
Details

PTPN22 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
Mouse (Murine) ,


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Rat (Rattus) ,


Am meisten referenzierte anti-PTPN22 Antikörper

  1. Human Polyclonal PTPN22 Primary Antibody für WB - ABIN525622 : Cao, Yang, Colby, Hogan, Hu, Jennette, Berg, Zhang, Jennette, Falk, Preston: High basal activity of the PTPN22 gain-of-function variant blunts leukocyte responsiveness negatively affecting IL-10 production in ANCA vasculitis. in PLoS ONE 2012 (PubMed)

Weitere Antikörper gegen PTPN22 Interaktionspartner

Mouse (Murine) Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22) Interaktionspartner

  1. Our findings, for the first time, illustrate the indirect impact of the 619 Arg > Trp (zeige TYRP1 Antikörper) polymorphic PTPN22 on T cells activation, mediated by polymorphic effects on macrophages and indicate a possible role of PTPN22 in cytoskeleton re-arrangement.

  2. PTPN22 has dual roles in T-cell clonal expansion and effector function; whereas it promotes antigen-driven responses during acute infection by positively regulating interferon (zeige IFNA Antikörper) signaling in T cells, PTPN22 inhibits homeostatic-driven proliferation.

  3. PTPN22 colocalized with its substrates at the leading edge of cells migrating on surfaces coated with the LFA-1 (zeige ITGAL Antikörper) ligand intercellular adhesion molecule-1 (ICAM-1 (zeige ICAM1 Antikörper)).

  4. in the absence of PAG, Csk becomes more associated with alternative partners; i.e., phosphatase PTPN22 and Dok adaptors. Combining PAG deficiency with PTPN22 or Dok adaptor deficiency further enhances effector T cell responses. Unlike PAG, Cbl ubiquitin ligases inhibit the activation of naive, but not of effector, T cells.

  5. PTPN22 is dispensable for dendritic cell antigen processing and promotion of T-cell activation by dendritic cells.

  6. collective murine and human data provide an alternative model for how the PTPN22 C1858T variant promotes self-reactivity into the naive B cell repertoire and, consequently, is likely to increase the probability of triggering autoimmune B cell responses in at-risk individuals

  7. PTPN22 deficiency resulted in pronounced colitis, increased NLRP3 (zeige NLRP3 Antikörper) phosphorylation, but reduced levels of mature IL-1beta (zeige IL1B Antikörper).

  8. We show that PTPN22 deficiency enhanced T-cell receptor-mediated signaling in SKG Ptpn22-/- thymocytes and that the early stages of thymus positive selection were partially restored in SKG Ptpn22-/- mice.

  9. this study shows that neutrophil effector functions are reduced in Ptpn22-/- neutrophils, and that Ptpn22-/- mice are protected from immune complex-mediated arthritis

  10. report demonstrates enhanced T1D in a mouse modeling human PTPN22(R620W) and the utility of CRISPR-Cas9 for direct genetic alternation of NOD mice.

Human Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22) Interaktionspartner

  1. PTPN22 single nucleotide polymorphism is associated with type 1 diabetes in Iran

  2. Relationship with insulin (zeige INS Antikörper)-dependent diabetes mellitus was found only in polymorphism R620W

  3. PTPN22 colocalized with its substrates at the leading edge of cells migrating on surfaces coated with the LFA-1 (zeige ITGAL Antikörper) ligand intercellular adhesion molecule-1 (ICAM-1 (zeige ICAM1 Antikörper)).

  4. collective murine and human data provide an alternative model for how the PTPN22 C1858T variant promotes self-reactivity into the naive B cell repertoire and, consequently, is likely to increase the probability of triggering autoimmune B cell responses in at-risk individuals

  5. The associations observed between PTPN22 (C1858T) and the risk of endometriosis suggest this polymorphism might be a useful susceptibility marker for this disease.

  6. PTPN22 deficiency resulted in pronounced colitis, increased NLRP3 (zeige NLRP3 Antikörper) phosphorylation, but reduced levels of mature IL-1beta (zeige IL1B Antikörper).

  7. the coding regions of 17 genes involved in the regulation of the immune response were determined by massive parallel sequencing. The analysis revealed 39 nonsynonymous SNPs that lead to amino acid substitutions, including the following informative genetic markers: PTPN22 c.1858C>T (rs2476601), TLR4 (zeige TLR4 Antikörper) c.896A>G (rs4986790) and TLR4 (zeige TLR4 Antikörper) c.1196C>T (rs4986791), IL7R (zeige IL7R Antikörper) c.197T>C (rs1494555) and IL7R (zeige IL7R Antikörper) c.412G>A (rs1494558).

  8. PTPN22 variants are associated with ANCA-associated vasculitis risk.

  9. C1858T polymorphism of protein tyrosine phosphatase (zeige ACP1 Antikörper) non-receptor type 22 characterizes a subset of type 1 diabetic patients with higher levels of C-peptide at diagnosis and lower insulin (zeige INS Antikörper) requirement at 6 months from diagnosis.

  10. The presence of PTPN22 1858C-->T polymorphism with HLA shared epitope and autoantibodies increases risk of rheumaotid arthritis development and erosive disease.

PTPN22 Antigen-Profil

Protein Überblick

This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Genbezeichner und Symbole assoziert mit PTPN22

  • protein tyrosine phosphatase, non-receptor type 22 (lymphoid) (Ptpn22) Antikörper
  • protein tyrosine phosphatase, non-receptor type 22 (PTPN22) Antikörper
  • protein tyrosine phosphatase, non-receptor type 22 (Ptpn22) Antikörper
  • 70zpep Antikörper
  • LYP Antikörper
  • LYP1 Antikörper
  • LYP2 Antikörper
  • PEP Antikörper
  • PTPN8 Antikörper

Bezeichner auf Proteinebene für PTPN22

PEST domain-enriched tyrosine phosphatase , hematopoietic cell protein-tyrosine phosphatase 70Z-PEP , protein tyrosine phosphatase, non-receptor type 8 , tyrosine-protein phosphatase non-receptor type 22 , PEST-domain phosphatase , lymphoid phosphatase , lymphoid-specific protein tyrosine phosphatase

GENE ID SPEZIES
19260 Mus musculus
26191 Homo sapiens
295338 Rattus norvegicus
Ausgewählte Anbieter für anti-PTPN22 (PTPN22) Antikörper
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