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TSSC4 is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Zusätzlich bieten wir Ihnen TSSC4 Antikörper (8) und TSSC4 Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.
TSSC4 gene, located in the center of the 11p15 imprinted region, escapes genomic imprinting.
imprinting status of four cattle genes (Tssc4,Nap1l4 (zeige NAP1L4 ELISA Kits), Phlda2 (zeige PHLDA2 ELISA Kits) and Osbpl5 (zeige OSBPL5 ELISA Kits)) in seven types of tissues, were assessed in cattle.
The orthologous gene pair, Tssc4/TSSC4, shows difference in imprinting between mouse and human. Mouse Tssc4 gene is imprinted, with preferential expression from the maternal allele in placenta, whereas, human TSSC4 gene is not imprinted.
This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene is located among several imprinted genes\; however, this gene, as well as the pan-hematopoietic expression gene (PHEMX), escapes imprinting. This gene may play a role in malignancies and disease that involve this region.
, tumor-suppressing STF cDNA 4 protein
, tumor-suppressing subchromosomal transferable fragment candidate gene 4 protein
, tumor-suppressing subchromosomal transferable fragment 4