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TNFRSF18 encodes a member of the TNF-receptor superfamily. Zusätzlich bieten wir Ihnen TNFRSF18 Antikörper (326) und TNFRSF18 Kits (19) und viele weitere Produktgruppen zu diesem Protein an.
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Human TNFRSF18 Protein expressed in HEK-293 Cells - ABIN2181162
Gurney, Marsters, Huang, Pitti, Mark, Baldwin, Gray, Dowd, Brush, Heldens, Schow, Goddard, Wood, Baker, Godowski, Ashkenazi: Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR. in Current biology : CB 1999
Continuous GITR stimulation through B cell Gitrl (zeige TNFSF18 Proteine) acts protective in a mouse model of atherosclerosis by regulating the balance between regulatory and effector memory CD4 (zeige CD4 Proteine)(+) T cells.
these results indicate that blockade of GITR signaling can ameliorate arthritis progression mainly by modulating the follicular helper T cell response
GITR appears as a potential target for intervention during infection by the parasite Toxoplasma gondii, even though further studies are still necessary to better characterize the immune response triggered by GITR activation during T. gondii infection
our data suggest a critical role for GITR in Treg cell homeostasis and indicate that Ptpn22 (zeige PTPN22 Proteine) independently affects the differentiation status of Treg cells and their homeostatic behavior
These findings provide further support for the continued development of agonist anti-GITR antibodies as an immunotherapeutic strategy for osteosarcoma. We suggest that our proposed immunotherapy could be developed further to improve osteosarcoma treatment
Th9 cells and iTregs are developmentally linked and GITR can subvert tolerogenic conditions to boost Th9 immunity.
GITR is a crucial player in differentiation of thymic regulatory T cells and expansion of regulatory T cells, including both thymic regulatory T cells and peripheral regulatory T cells.
enhanced GITR-triggering mediates its protective, anti-viral effect on the CD8 (zeige CD8A Proteine) T cell compartment by boosting CD4 (zeige CD4 Proteine) T cell help.
A CD4 (zeige CD4 Proteine) T cell-intrinsic role for GITR in sustaining early CD8 (zeige CD8A Proteine) and late humoral responses to collectively promote control of chronic LCMV clone 13 infection.
GITRL (zeige TNFSF18 Proteine) expressed on macrophages drives cytokine release and T cell activation, resulting in neuropathic pain via GITR-dependent actions. The GITRL (zeige TNFSF18 Proteine)-GITR pathway might represent a novel target for the treatment of neuropathic pain.
Aberrant expression of GITR may contribute to systemic lupus erithematosus pathogenesis. Glucocorticoid may achieve its therapeutic effect partly by inducing GITR expression on Tresps rather than Tregs, which initiates the apoptosis of Tresp cells in SLE patients.
GITR expression can enhance the sensitivity to Bortezomib by inhibiting Bortezomib-induced NF-kappaB (zeige NFKB1 Proteine) activation.
Data may suggest a key role of regulatory GITR+CD25 (zeige IL2RA Proteine) low/-CD4 (zeige CD4 Proteine)+ T cells subset in the modulation of the abnormal immune response in lupus erythematosus (SLE) patients.
results suggest that the GITR rs3753348 polymorphism may be involved in the development and susceptibility of CWP.
these results show a higher susceptibility to apoptosis in patients' versus controls' T(reg (zeige EXTL3 Proteine)) cells, suggesting that GITR is a T(reg (zeige EXTL3 Proteine))-cell marker that would be primarily involved in T(reg (zeige EXTL3 Proteine))-cell survival rather than in their suppressor function.
Our findings indicate the possible involvement of GITR-GITRL (zeige TNFSF18 Proteine) pathway in the pathogenesis of pSS (zeige CDSN Proteine).
GITR acts as a potential tumor suppressor in MM.
Data indicate that the mRNAs of CTLA-4 (zeige CTLA4 Proteine) and GITR genes were expressed at lower levels in CVID (zeige TNFRSF13B Proteine) patients compared to control group.
GITR is pathologically expressed on Treg cells in systemic lupus erythematosus.
This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
tumor necrosis factor receptor superfamily member 18
, glucocorticoid-induced TNFR-related
, tumor necrosis factor receptor superfamily, member 18
, glucocorticoid-induced TNFR-related protein
, TNF receptor superfamily activation-inducible protein
, activation-inducible TNFR family receptor