Tumor Necrosis Factor Receptor Superfamily, Member 18 Proteine (TNFRSF18)

TNFRSF18 encodes a member of the TNF-receptor superfamily. Zusätzlich bieten wir Ihnen TNFRSF18 Antikörper (340) und TNFRSF18 Kits (19) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
TNFRSF18 21936 O35714
TNFRSF18 8784 Q9Y5U5
TNFRSF18 500598  
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Showing 10 out of 35 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HOST_HEK-293 Cells Human His tag Human GITR, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 92%. Immobilized Human GITR, His Tag (Cat# GIR-H5228) at 2 μg/mL (100 μl/well) can bind Human GITR Ligand, Fc Tag (Cat# GIL-H526a ) with a linear range of 0.8-25 ng/mL. 100 μg Anmelden zum Anzeigen 9 bis 10 Tage
360,00 €
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Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
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Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 46 bis 51 Tage
4.032,65 €
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HOST_Human Cells Human His tag,ECD 100 μg Anmelden zum Anzeigen 18 bis 20 Tage
287,50 €
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HOST_HEK-293 Cells Maus Fc Tag   50 μg Anmelden zum Anzeigen 2 bis 5 Tage
325,00 €
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HOST_HEK-293 Cells Human Fc Tag   50 μg Anmelden zum Anzeigen 2 bis 5 Tage
355,00 €
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HOST_HEK-293 Cells Ratte His tag Rat GITR, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 100 μg Anmelden zum Anzeigen 9 bis 10 Tage
360,00 €
Details
HOST_HEK-293 Cells Rhesusaffen Fc Tag Rhesus macaque GITR, Fc Tag on SDS-PAGE under reducing (R) and no-reducing (NR) conditions. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 100 μg Anmelden zum Anzeigen 9 bis 10 Tage
428,57 €
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HOST_Mammalian Cells Maus Fc Tag,His tag   50 μg Anmelden zum Anzeigen 8 bis 9 Tage
324,76 €
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HOST_Human Cells Ratte Fc Tag 100 μg Anmelden zum Anzeigen 18 bis 20 Tage
450,00 €
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TNFRSF18 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine) , , ,
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Human , , , , ,
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Rat (Rattus) ,
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Am meisten referenzierte TNFRSF18 Proteine

  1. Human TNFRSF18 Protein expressed in HEK-293 Cells - ABIN2181162 : Gurney, Marsters, Huang, Pitti, Mark, Baldwin, Gray, Dowd, Brush, Heldens, Schow, Goddard, Wood, Baker, Godowski, Ashkenazi: Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR. in Current biology : CB 1999 (PubMed)

Weitere Proteine zu Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18) Interaktionspartnern

Mouse (Murine) Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18) Interaktionspartner

  1. anti-GITR mAb shifts Treg populations to enable immune attack on tumors, with clinical implications for molecular markers to modify emerging treatments.

  2. Continuous GITR stimulation through B cell Gitrl (zeige TNFSF18 Proteine) acts protective in a mouse model of atherosclerosis by regulating the balance between regulatory and effector memory CD4 (zeige CD4 Proteine)(+) T cells.

  3. these results indicate that blockade of GITR signaling can ameliorate arthritis progression mainly by modulating the follicular helper T cell response

  4. GITR appears as a potential target for intervention during infection by the parasite Toxoplasma gondii, even though further studies are still necessary to better characterize the immune response triggered by GITR activation during T. gondii infection

  5. our data suggest a critical role for GITR in Treg cell homeostasis and indicate that Ptpn22 (zeige PTPN22 Proteine) independently affects the differentiation status of Treg cells and their homeostatic behavior

  6. These findings provide further support for the continued development of agonist anti-GITR antibodies as an immunotherapeutic strategy for osteosarcoma. We suggest that our proposed immunotherapy could be developed further to improve osteosarcoma treatment

  7. Th9 cells and iTregs are developmentally linked and GITR can subvert tolerogenic conditions to boost Th9 immunity.

  8. GITR is a crucial player in differentiation of thymic regulatory T cells and expansion of regulatory T cells, including both thymic regulatory T cells and peripheral regulatory T cells.

  9. enhanced GITR-triggering mediates its protective, anti-viral effect on the CD8 (zeige CD8A Proteine) T cell compartment by boosting CD4 (zeige CD4 Proteine) T cell help.

  10. A CD4 (zeige CD4 Proteine) T cell-intrinsic role for GITR in sustaining early CD8 (zeige CD8A Proteine) and late humoral responses to collectively promote control of chronic LCMV clone 13 infection.

Human Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18) Interaktionspartner

  1. HTLV-1 infection can modify the expression of main functional transcription factors, FOXP3 (zeige FOXP3 Proteine) and GITR

  2. a novel molecular mechanism by which MBD4 (zeige MBD4 Proteine) inhibits GITR expression in a DNMT1 (zeige DNMT1 Proteine)-dependent manner

  3. Aberrant expression of GITR may contribute to systemic lupus erithematosus pathogenesis. Glucocorticoid may achieve its therapeutic effect partly by inducing GITR expression on Tresps rather than Tregs, which initiates the apoptosis of Tresp cells in SLE patients.

  4. GITR expression can enhance the sensitivity to Bortezomib by inhibiting Bortezomib-induced NF-kappaB (zeige NFKB1 Proteine) activation.

  5. GITR is a crucial player in differentiation of thymic regulatory T cells and expansion of regulatory T cells, including both thymic regulatory T cells and peripheral regulatory T cells.

  6. Data may suggest a key role of regulatory GITR+CD25 (zeige IL2RA Proteine) low/-CD4 (zeige CD4 Proteine)+ T cells subset in the modulation of the abnormal immune response in lupus erythematosus (SLE) patients.

  7. results suggest that the GITR rs3753348 polymorphism may be involved in the development and susceptibility of CWP.

  8. these results show a higher susceptibility to apoptosis in patients' versus controls' T(reg (zeige EXTL3 Proteine)) cells, suggesting that GITR is a T(reg (zeige EXTL3 Proteine))-cell marker that would be primarily involved in T(reg (zeige EXTL3 Proteine))-cell survival rather than in their suppressor function.

  9. Our findings indicate the possible involvement of GITR-GITRL (zeige TNFSF18 Proteine) pathway in the pathogenesis of pSS (zeige CDSN Proteine).

  10. GITR acts as a potential tumor suppressor in MM.

TNFRSF18 Protein Überblick

Protein Überblick

This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Genbezeichner und Symbole assoziert mit TNFRSF18

  • tumor necrosis factor receptor superfamily, member 18 (TNFRSF18)
  • tumor necrosis factor receptor superfamily, member 18 (Tnfrsf18)
  • AITR Protein
  • CD357 Protein
  • Gitr Protein
  • GITR-D Protein
  • TNFRSF18 Protein

Bezeichner auf Proteinebene für TNFRSF18

tumor necrosis factor receptor superfamily member 18 , glucocorticoid-induced TNFR-related , tumor necrosis factor receptor superfamily, member 18 , glucocorticoid-induced TNFR-related protein , TNF receptor superfamily activation-inducible protein , activation-inducible TNFR family receptor

GENE ID SPEZIES
419424 Gallus gallus
516256 Bos taurus
606971 Canis lupus familiaris
699559 Macaca mulatta
741567 Pan troglodytes
21936 Mus musculus
8784 Homo sapiens
500598 Rattus norvegicus
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