Tumor Necrosis Factor (Ligand) Superfamily, Member 18 Proteine (TNFSF18)

The protein encoded by TNFSF18 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. Zusätzlich bieten wir Ihnen Tumor Necrosis Factor (Ligand) Superfamily, Member 18 Antikörper (184) und Tumor Necrosis Factor (Ligand) Superfamily, Member 18 Kits (14) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
TNFSF18 8995 Q9UNG2
TNFSF18 240873 Q7TS55
Ratte TNFSF18 TNFSF18 364031  
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Showing 10 out of 38 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HOST_HEK-293 Cells Human DYKDDDDK Tag Flag-tagged GITRL bound to GITR transfected cells. HEK-293 cells were transiently transfected with a construct encoding human GITR full length. At 48hr after transfection, the transfectants were incubated with 5μg/ml of human FLAG-tagged GITRL  protein and followed by flow cytometric analysis with anti-FLAG M2-FITC. 50 μg Anmelden zum Anzeigen 2 bis 5 Tage
415,00 €
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 26 bis 31 Tage
4.115,41 €
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Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 46 bis 51 Tage
5.743,80 €
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HOST_HEK-293 Human Unkonjugiert   10 μg Anmelden zum Anzeigen 6 bis 8 Tage
129,41 €
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Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 46 bis 51 Tage
4.032,65 €
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HOST_Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 26 bis 31 Tage
4.115,41 €
Details
HOST_Escherichia coli (E. coli) Human Unkonjugiert 100 μg Anmelden zum Anzeigen 11 bis 15 Tage
303,81 €
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HOST_HEK-293 Cells Maus DYKDDDDK Tag   50 μg Anmelden zum Anzeigen 2 bis 5 Tage
395,00 €
Details
HOST_HEK-293 Cells Human Fc Tag Human GITR Ligand, Fc Tag on SDS-PAGE under reducing (R) and no-reducing (NR) conditions. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. Immobilized Human GITR, His Tag (Cat# GIR-H5228) at 2 μg/mL (100 μl/well) can bind Human GITR Ligand, Fc Tag (Cat# GIL-H526a ) with a linear range of 0.8-25 ng/mL. 50 μg Anmelden zum Anzeigen 6 bis 8 Tage
428,57 €
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HOST_Mammalian Cells Human His tag   50 μg Anmelden zum Anzeigen 8 bis 9 Tage
392,86 €
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TNFSF18 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , , , , ,
, , , , , ,
Mouse (Murine) , ,
, , ,

Am meisten referenzierte Tumor Necrosis Factor (Ligand) Superfamily, Member 18 Proteine

  1. Human TNFSF18 Protein expressed in HEK-293 - ABIN2666573 : Azuma: Role of the glucocorticoid-induced TNFR-related protein (GITR)-GITR ligand pathway in innate and adaptive immunity. in Critical reviews in immunology 2010 (PubMed)
    Zeige alle 8 Referenzen für 2666573

  2. Human TNFSF18 Protein expressed in Escherichia coli (E. coli) - ABIN667587 : Gurney, Marsters, Huang, Pitti, Mark, Baldwin, Gray, Dowd, Brush, Heldens, Schow, Goddard, Wood, Baker, Godowski, Ashkenazi: Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR. in Current biology : CB 1999 (PubMed)
    Zeige alle 2 Referenzen für 667587

Weitere Proteine zu Tumor Necrosis Factor (Ligand) Superfamily, Member 18 (TNFSF18) Interaktionspartnern

Human Tumor Necrosis Factor (Ligand) Superfamily, Member 18 (TNFSF18) Interaktionspartner

  1. GITRL levels are significantly elevated in rheumatoid arthritis serum and synovial fluid and are positively correlated with autoantibody production in rheumatoid arthritis, suggesting a role of GITRL in the development of rheumatoid arthritis.

  2. GITRL modulates the activities of p38 MAPK (zeige MAPK14 Proteine) and STAT3 (zeige STAT3 Proteine) to promote Th17 cell differentiation in autoimmune arthritis.

  3. An increase in GITRL may impair the balance of Th17/Treg, and contribute to the pathopoiesis of Hashimoto's thyroiditis.

  4. Our findings indicate the possible involvement of GITR (zeige TNFRSF18 Proteine)-GITRL pathway in the pathogenesis of pSS (zeige CDSN Proteine).

  5. Serum GITRL levels were higher in SLE patients.

  6. Glucocorticoid-induced TNF-related ligand (GITRL) confers pseudoexpression to tumor cells by platelets, which results in GITRL expression by megakaryocytes and their platelet progeny.

  7. observation suggests a link between cytokine-regulated keratinocyte GITRL expression and its role in inflammatory responses in AD

  8. GITRL upregulation induced by IFN-beta (zeige IFNB1 Proteine) on dendritic cells downregulates CTLA-4 (zeige CTLA4 Proteine) on regulatory T (Treg) cells, facilitating proliferation of anergic Treg cells in multiple sclerosis treatment of multiple sclerosis patients.

  9. Although GITR (zeige TNFRSF18 Proteine) transgene costimulation can therapeutically enhance T helper (Th) type 2 cell responses, GITR-GITR (zeige TNFRSF18 Proteine) ligand interactions are not required for development of Th2-mediated resistance or pathology.

  10. GITRL expression on Kupffer cells may mediate acute rejection in liver transplantation

Mouse (Murine) Tumor Necrosis Factor (Ligand) Superfamily, Member 18 (TNFSF18) Interaktionspartner

  1. the upregulation of IFN-beta (zeige IFNB1 Proteine) in DCs induces the up-regulation of coinhibitory molecules B7H1 (zeige CD274 Proteine) and GITRL, which cause an impaired activation of naive Ag-specific T cells

  2. GITRL expressed on macrophages drives cytokine release and T cell activation, resulting in neuropathic pain via GITR (zeige TNFRSF18 Proteine)-dependent actions. The GITRL-GITR (zeige TNFRSF18 Proteine) pathway might represent a novel target for the treatment of neuropathic pain.

  3. Down-regulation of GITRL enhances CD8 (zeige CD8A Proteine) T cell responses to chronic lymphocytic choriomeningitis virus.

  4. Sjogren's syndrome-like autoimmune sialadenitis in MRL-Faslpr mice is associated with expression of glucocorticoid-induced TNF receptor-related protein (GITR) ligand and 4-1BB ligand (zeige TNFSF9 Proteine).

  5. GITRL triggering in endothelial cells increases leukocyte adhesion and transmigration.

  6. The B7H1 (zeige CD274 Proteine) and GITRL molecules may play an important role in TGF-beta (zeige TGFB1 Proteine)-induced Treg expansion of lung cancer microenvironment.

  7. results demonstrate that enhanced GITR (zeige TNFRSF18 Proteine)/GITRL interactions have a pleiotropic role on the regulation of T-cell responses

  8. B cell expression of GITRL induced Treg proliferation, maintaining their numbers above a threshold required for the prevention of autoimmunity.

  9. Findings suggest GITRL could enhance the immune stimulation of DC and might facilitate the potential development of DCs-based anti-tumor therapies.

  10. GITRL-dependent expansion of Treg within the cornea is one mechanism underlying immune privilege in corneal allografts.

Tumor Necrosis Factor (Ligand) Superfamily, Member 18 (TNFSF18) Protein Überblick

Protein Überblick

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells.

Genbezeichner und Symbole assoziert mit TNFSF18

  • tumor necrosis factor (ligand) superfamily, member 18 (TNFSF18)
  • tumor necrosis factor (ligand) superfamily, member 18 (Tnfsf18)
  • AITRL Protein
  • Gitrl Protein
  • hGITRL Protein
  • TL6 Protein

Bezeichner auf Proteinebene für TNFSF18

AITR ligand , GITR ligand , activation-inducible TNF-related ligand , glucocorticoid-induced TNF-related ligand , glucocorticoid-induced TNFR-related protein ligand , tumor necrosis factor ligand superfamily member 18 , glucocorticoid-induced-tumor necrosis factor receptor ligand

GENE ID SPEZIES
8995 Homo sapiens
240873 Mus musculus
364031 Rattus norvegicus
611257 Canis lupus familiaris
Ausgewählte Anbieter für Tumor Necrosis Factor (Ligand) Superfamily, Member 18 Proteine (TNFSF18)
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