Tryptophan 2,3-Dioxygenase Proteine (TDO2)

TDO2 encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Zusätzlich bieten wir Ihnen Tryptophan 2,3-Dioxygenase Antikörper (51) und Tryptophan 2,3-Dioxygenase Kits (21) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
TDO2 6999 P48775
TDO2 56720 P48776
TDO2 64206 P21643
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Showing 10 out of 15 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HOST_Escherichia coli (E. coli) Human Unkonjugiert 0.05 mg Anmelden zum Anzeigen 6 bis 8 Tage
407,27 €
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HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 26 bis 31 Tage
4.115,41 €
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HOST_Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 26 bis 31 Tage
4.115,41 €
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HOST_Escherichia coli (E. coli) Human His tag 10 μg Anmelden zum Anzeigen 11 bis 15 Tage
303,81 €
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HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Bioactivity measured with Activity Assay Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
748,00 €
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HOST_Escherichia coli (E. coli) Moskito His tag   50 μg Anmelden zum Anzeigen 2 bis 5 Tage
455,00 €
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Hefe Xenopus tropicalis His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.976,98 €
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Hefe Xenopus laevis His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.976,98 €
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.976,98 €
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TDO2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine)

Rat (Rattus)

Weitere Proteine zu Tryptophan 2,3-Dioxygenase (TDO2) Interaktionspartnern

Human Tryptophan 2,3-Dioxygenase (TDO2) Interaktionspartner

  1. the potent antimicrobial as well as immunoregulatory effects of TDO (zeige DLX3 Proteine) were substantially impaired under hypoxic conditions that pathophysiologically occur in vivo. This might be detrimental for the appropriate host immune response towards relevant pathogens.

  2. High TDO2 expression is associated with Colorectal Cancer.

  3. Crystal tryptophan 2,3-dioxygenase structure revealed eight residues playing critical roles in L-tryptophan oxidation.

  4. IL-1beta (zeige IL1B Proteine) is suggested to stimulate tryptophan catabolism and production of IL-6 (zeige IL6 Proteine) and IL-8 (zeige IL8 Proteine) by increasing TDO (zeige DLX3 Proteine) expression in endometriosis.

  5. Identification of 12 polymorphisms in the human TDO2 promoter region, 2 of them corresponding to previously unknown single-nucleotide polymorphisms and 3 of them located in putative glucocorticoid-responsive elements.

  6. TDO (zeige DLX3 Proteine) is highly expressed in the brains of Alzheimer disease patients.

  7. The data suggest that TDO (zeige DLX3 Proteine) uses a ring-opening mechanism during N-formylkynurenine formation, rather than Criegee or dioxetane mechanisms as previously proposed.

  8. subtle differences between the TDO (zeige DLX3 Proteine) and IDO (zeige IDO1 Proteine) reactions

  9. Polymorphism of tryptophan 2,3 dioxygenase gene is associated with autism.

  10. We found that astrocytes, neurons, and microglia expressed IDO (zeige IDO1 Proteine) but only microglia were able to produce detectable amounts of quinolinic acid. However, astrocytes and neurons had the ability to catabolize quinolinic acid.

Mouse (Murine) Tryptophan 2,3-Dioxygenase (TDO2) Interaktionspartner

  1. both TDO and IDO (zeige IDO1 Proteine) biosynthesize nicotinamide from D-tryptophan and L-tryptophan in mice

  2. Data indicate that tryptophan 2,3-dioxygenase (Tdo2) may play an important role during mouse decidualization and be regulated by estrogen, progesterone, and cAMP.

  3. These findings demonstrate a direct molecular link between Trp (zeige TYRP1 Proteine) metabolism and neurogenesis and anxiety-related behavior under physiological conditions.

  4. Endometrial expression of TDO in epithelial and stromal cells is regulated by HOXA10 (zeige HOXA10 Proteine). Expression level of TDO influences infiltration of T-cells into endometrial stroma and thus may influence embryo viability.

  5. These findings indicate that TDO might be required at a late-stage of granule cell development, such as during axonal and dendritic growth, synaptogenesis and its maturation.

  6. No relationship was found between alcohol consumption, Tdo2 activity, and single nucleotide substitution in intron 6 of the Tdo2 gene assoiated with predisposition to alcoholism in humans.

  7. Our findings indicate that TDO and its novel variants may play an important role in not only the liver but also in local areas in developing and adult brain.

Tryptophan 2,3-Dioxygenase (TDO2) Protein Überblick

Protein Überblick

This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism.

Genbezeichner und Symbole assoziert mit TDO2

  • tryptophan 2,3-dioxygenase b (tdo2b)
  • tryptophan 2,3-dioxygenase (tdo2)
  • tryptophan 2,3-dioxygenase (TDO2)
  • tryptophan 2,3-dioxygenase (MADE_02822)
  • tryptophan 2,3-dioxygenase (CtCNB1_3657)
  • tryptophan 2,3-dioxygenase a (tdo2a)
  • tryptophan 2,3-dioxygenase (CNC04830)
  • tryptophan 2,3-dioxygenase (tdo)
  • tryptophan 2,3-dioxygenase (Mrub_2119)
  • tryptophan 2,3-dioxygenase (Deipr_2235)
  • tryptophan 2,3-dioxygenase (Acav_1166)
  • tryptophan 2,3-dioxygenase (Mesop_4278)
  • tryptophan 2,3-dioxygenase (Tdo2)
  • tryptophan 2,3-dioxygenase (TDO)
  • AA407491 Protein
  • chky Protein
  • DDBDRAFT_0190495 Protein
  • DDBDRAFT_0231363 Protein
  • DDB_0190495 Protein
  • DDB_0231363 Protein
  • fb62b10 Protein
  • fi30d08 Protein
  • Tdo Protein
  • tdo2 Protein
  • tdo2l Protein
  • TO Protein
  • TPH2 Protein
  • TRPO Protein
  • wu:fb62b10 Protein
  • wu:fi30d08 Protein
  • zgc:63488 Protein
  • zgc:103693 Protein

Bezeichner auf Proteinebene für TDO2

TDO-B , TO-B , TRPO-B , tryptamin 2,3-dioxygenase B , tryptophan 2,3-dioxygenase B , tryptophan 2,3-dioxygenase, like , tryptophan oxygenase B , tryptophan pyrrolase B , tryptophanase B , TDO , TO , TRPO , tryptamin 2,3-dioxygenase , tryptophan oxygenase , tryptophan pyrrolase , tryptophanase , tryptophan 2,3-dioxygenase , TDO-A , TO-A , TRPO-A , tryptamin 2,3-dioxygenase A , tryptophan 2,3-dioxygenase A , tryptophan oxygenase A , tryptophan pyrrolase A , tryptophanase A , tdo variant1 , tdo variant2 , tryptophan-2,3-dioxygenase , tryptophan-23-dioxygenase

GENE ID SPEZIES
334082 Danio rerio
548450 Xenopus (Silurana) tropicalis
699739 Macaca mulatta
736252 Pan troglodytes
4456236 Ralstonia eutropha H16
4649802 Gramella forsetii KT0803
6776077 Alteromonas macleodii 'Deep ecotype'
8562285 Comamonas testosteroni CNB-2
100008541 Danio rerio
3256592 Cryptococcus neoformans var. neoformans JEC21
8617171 Dictyostelium discoideum AX4
8880228 Meiothermus ruber DSM 1279
10265555 Deinococcus proteolyticus MRP
10306071 Acidovorax avenae subsp. avenae ATCC 19860
10828127 Mesorhizobium opportunistum WSM2075
6999 Homo sapiens
475476 Canis lupus familiaris
56720 Mus musculus
64206 Rattus norvegicus
530397 Bos taurus
100344083 Oryctolagus cuniculus
100727713 Cavia porcellus
100301559 Sus scrofa
422409 Gallus gallus
495495 Xenopus laevis
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