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anti-Troponin T2, Cardiac (TNNT2) Antikörper

The protein encoded by TNNT2 is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Zusätzlich bieten wir Ihnen Cardiac Troponin T2 Kits (69) und Cardiac Troponin T2 Proteine (35) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
TNNT2 7139 P45379
TNNT2 24837 P50753
TNNT2 21956 P50752
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Top anti-Cardiac Troponin T2 Antikörper auf antikoerper-online.de

Showing 10 out of 374 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
Details
Huhn Maus Unkonjugiert IF, IHC (p) 0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
495,00 €
Details
Human Kaninchen Unkonjugiert EIA, WB TNNT2 Antibody (Center) western blot analysis in mouse heart tissue lysates (35 µg/lane). This demonstrates the TNNT2 antibody detected the TNNT2 protein (arrow). 0.4 mL Anmelden zum Anzeigen 7 bis 9 Tage
407,00 €
Details
Cat Maus Unkonjugiert EIA, IHC (p), IP, WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
517,00 €
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Cat Maus Unkonjugiert EIA, IHC (p), IP, WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
517,00 €
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Rind (Kuh) Maus Unkonjugiert EIA, WB   0.2 mg Anmelden zum Anzeigen 7 bis 9 Tage
363,00 €
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Human Maus Unkonjugiert EIA, IHC (p) 0.25 mg Anmelden zum Anzeigen 7 bis 9 Tage
517,00 €
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Human Maus Unkonjugiert IA, WB   0.2 mg Anmelden zum Anzeigen 2 bis 4 Tage
212,00 €
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Human Maus Unkonjugiert EIA, WB 0.2 mg Anmelden zum Anzeigen 7 bis 9 Tage
396,00 €
Details
Human Maus Unkonjugiert EIA, FACS, WB 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
473,00 €
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TNNT2 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

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Am meisten referenzierte anti-Cardiac Troponin T2 Antikörper

  1. Human Polyclonal Cardiac Troponin T2 Primary Antibody für EIA, WB - ABIN951043 : Millat, Chanavat, Créhalet, Rousson: Development of a high resolution melting method for the detection of genetic variations in hypertrophic cardiomyopathy. in Clinica chimica acta; international journal of clinical chemistry 2010 (PubMed)
    Zeige alle 3 Referenzen für ABIN951043

  2. Cow (Bovine) Polyclonal Cardiac Troponin T2 Primary Antibody für WB - ABIN2776953 : Klaassen, Probst, Oechslin, Gerull, Krings, Schuler, Greutmann, Hürlimann, Yegitbasi, Pons, Gramlich, Drenckhahn, Heuser, Berger, Jenni, Thierfelder: Mutations in sarcomere protein genes in left ventricular noncompaction. in Circulation 2008 (PubMed)

  3. Chicken Monoclonal Cardiac Troponin T2 Primary Antibody für IF, IHC (p) - ABIN180606 : Malouf, McMahon, Oakeley, Anderson: A cardiac troponin T epitope conserved across phyla. in The Journal of biological chemistry 1992 (PubMed)

  4. Human Monoclonal Cardiac Troponin T2 Primary Antibody für EIA, FACS - ABIN1105666 : Hershberger, Pinto, Parks, Kushner, Li, Ludwigsen, Cowan, Morales, Parvatiyar, Potter: Clinical and functional characterization of TNNT2 mutations identified in patients with dilated cardiomyopathy. in Circulation. Cardiovascular genetics 2009 (PubMed)

  5. Human Monoclonal Cardiac Troponin T2 Primary Antibody für IA, WB - ABIN265695 : Qiao, Tang, Munske, Dutta, Ivory, Dong: Enhanced fluorescence anisotropy assay for human cardiac troponin I and T detection. in Journal of fluorescence 2011 (PubMed)

Weitere Antikörper gegen Cardiac Troponin T2 Interaktionspartner

Human Troponin T2, Cardiac (TNNT2) Interaktionspartner

  1. Generated is a gene-targeted knock-in murine model of the autosomal dominant Arg141Trp (R141W) mutation in human Tnnt2. Tnnt2 R141W mutation causes a Ca2 (zeige CA2 Antikörper)+ desensitization and mice adapt by increasing Ca2 (zeige CA2 Antikörper)+-transient amplitudes, which impairs Ca2 (zeige CA2 Antikörper)+ handling dynamics, metabolism and responses to beta-adrenergic activation.

  2. A myosin activator improves actin assembly and sarcomere function of human-induced pluripotent stem cell-derived cardiomyocytes with a troponin T point mutation.

  3. Our study supports that mutations in MYH7 (zeige MYH7 Antikörper) and MYBPC3 (zeige MYBPC3 Antikörper) should be the first focus of moleculargenetic analysis in HCM, and that mutations in TNNT2 have a low prevalence in Brazilian population. All mutations detected were missense mutations, whereas two mutations in MYH7 (zeige MYH7 Antikörper) had not been described before.

  4. Dyrk1A modulates SRp55-promoted cTnT exon 5 inclusion

  5. Our results suggest that multiple enzymes are involved in cTnT degradation, and that thrombin (zeige F2 Antikörper) plays an important role.

  6. In patients with clinically stable angina pectoris, slightly elevated hs-cTnT levels may indicate the presence of complex coronary artery disease.

  7. TNNT2 gene mutation is associated with Early-Onset Hypertrophic Cardiomyopathy.

  8. The results showed that MYBPC3 25-bp deletion polymorphism was significantly associated with elevated risk of left ventricular dysfunction (LVD), while TTN 18 bp I/D, TNNT2 5 bp I/D and myospryn K2906N polymorphisms did not show any significant association with LVD.

  9. A novel heterozygous mutation (MYH7 (zeige MYH7 Antikörper), p.Asn885Thr), and a variant of uncertain significance (TNNT2, p.Arg296His) were identified in 2 patients with familial hypertrophic cardiomyopathy.

  10. Discordant elevation of cTnT in the presence of normal CK plasma levels on admission is associated with increased mortality in STEMI patients undergoing primary PCI (zeige SERPINA5 Antikörper).

Pig (Porcine) Troponin T2, Cardiac (TNNT2) Interaktionspartner

  1. We show that the phosphorylation of cTnI and alphaTm vary in the different chambers of the heart, whereas the phosphorylation of MLC2 and cTnT does not.

Cow (Bovine) Troponin T2, Cardiac (TNNT2) Interaktionspartner

  1. Significant changes in thin filament Ca2 (zeige CA2 Antikörper)+-sensitivity, structure and kinetics are brought about through PKC (zeige PKC Antikörper) phosphorylation of cardiac troponin T.

  2. The mu-calpain-mediated proteolytic modification of TnT by removing the NH2-terminal variable region of TnT may act as an acute mechanism to adjust muscle contractility under stress conditions.

Rabbit Troponin T2, Cardiac (TNNT2) Interaktionspartner

  1. Substituting smooth muscle caldesmon for skeletal muscle troponin produces a similar decrease and re-increase in fluorescence, but the apparent rate constant for the increase is >10 times that observed with troponin.

  2. In ischemic myocardium, the expression of cTnT showed prominent focal or flaky depletion in myocardial cytoplasm with no expression detected in interstitium.

Mouse (Murine) Troponin T2, Cardiac (TNNT2) Interaktionspartner

  1. TnTA30V mutation attenuated Ca(2 (zeige CA2 Antikörper)+)-activated maximal tension and length-mediated cross-bridge recruitment against alpha-myosin (zeige MYH6 Antikörper) heavy chain but augmented these parameters against beta-myosin heavy chain (zeige MYH7 Antikörper), suggesting divergent contractile phenotypes.

  2. The shift from cTnT exon 5 inclusion to exclusion during development was delayed in the heart of Ts65Dn mice due to Dyrk1A (zeige DYRK1A Antikörper) overexpression.

  3. for hypertrophic cardiomyopathy (HCM)-causing mutations in TnT (zeige TNNI1 Antikörper), Ca(2 (zeige CA2 Antikörper)+)-sensitisation together with uncoupling in vitro is the usual response and both factors may contribute to the HCM phenotype

  4. cardiomyopathy mutation (R97L) in mouse cardiac troponin T has an effect on the muscle length-mediated recruitment of crossbridges and is modified divergently by alpha- and beta-myosin heavy chain (zeige MYH7 Antikörper)

  5. Data indicate that high-sensitivity troponin T (hs-TnT) levels are influenced by myocardial dysfunction/heart failure (HF) in acute exacerbation of chronic obstructive lung disease (AECOPD), but provide independent prognostic information.

  6. cTnT elevation emerged as a strong, independent predictor of 30-day mortality and remained a modest, but significant, predictor throughout 2 years post transcatheter aortic valve implantation.

  7. MBPC and troponin-I phosphorylation modulate myofilament length-dependent activation

  8. Data indicate that the troponin T Tnnt2(MerCreMer/+) mouse model also provides a useful tool to trace myocardial lineage during development.

  9. TnT (zeige TNNI1 Antikörper) mutation F72L leads to contractile changes that are linked to dilated cardiomyopathy in the presence of MYH6 (zeige MYH6 Antikörper) and hypertrophic cardiomyopathy in the presence of MYH7 (zeige MYH7 Antikörper).

  10. TNT increases slightly during low flux-hemodialysis. High-flux hemodialysis eliminates the biomarker and can mask increases caused by cardiac disease.

Zebrafish Troponin T2, Cardiac (TNNT2) Interaktionspartner

  1. Data showed that CXCR4a was significantly more highly expressed in tnnt2 knocked down mutant at 48 and 60 hpf than controls.

  2. We show that the zebrafish silent heart (sih) mutation affects the gene tnnt2.

  3. Tnnt1 (zeige TNNI1 Antikörper), Tnnt2, and Tnnt3b were conserved in the central tropomyosin (zeige TPM2 Antikörper)- and C-terminal troponin I-binding domains but the N-terminal hypervariable regions were highly extended and rich in glutamic acid in polypeptides of Tnnt1 (zeige TNNI1 Antikörper) and Tnnt2, but not Tnnt3b.

Cardiac Troponin T2 (TNNT2) Antigen-Profil

Protein Überblick

The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined.

Genbezeichner und Symbole assoziert mit TNNT2

  • troponin T type 2 (cardiac) (TNNT2) Antikörper
  • troponin T2, cardiac (Tnnt2) Antikörper
  • troponin T type 2 (cardiac) (Tnnt2) Antikörper
  • troponin T type 2 (cardiac) (tnnt2) Antikörper
  • troponin T2a, cardiac (tnnt2a) Antikörper
  • CMH2 Antikörper
  • CMPD2 Antikörper
  • CT3 Antikörper
  • cTnT Antikörper
  • Ctt Antikörper
  • CTTG Antikörper
  • LVNC6 Antikörper
  • RATCTTG Antikörper
  • RCM3 Antikörper
  • tnnt2 Antikörper
  • Tnnt3 Antikörper
  • Tnt Antikörper
  • TnTC Antikörper

Bezeichner auf Proteinebene für TNNT2

troponin T, cardiac muscle , troponin T2, cardiac , cardiac troponin 2 , cardiac troponin T , troponin T type 2, cardiac , cardiomyopathy, dilated 1D (autosomal dominant) , cardiomyopathy, hypertrophic 2 , Troponin T cardiac , cTnT , cardiac muscle troponin T , cardiac troponin T2 , tnTc , cardiac troponin T form I , tnTC , troponin T, cardiac muscle isoforms , Troponin T, cardiac muscle , troponin T cardiac isoform , cardiac TnT , sih , silent heart

GENE ID SPEZIES
493940 Felis catus
100379561 Cavia porcellus
403532 Canis lupus familiaris
7139 Homo sapiens
24837 Rattus norvegicus
398518 Xenopus laevis
396433 Gallus gallus
100622450 Sus scrofa
286816 Bos taurus
100009428 Oryctolagus cuniculus
21956 Mus musculus
58071 Danio rerio
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