Tropomyosin-2 Proteine (TPM2)

TPM2 encodes beta-tropomyosin, a member of the actin filament binding protein family, and mainly expressed in slow, type 1 muscle fibers. Zusätzlich bieten wir Ihnen Tropomyosin-2 Antikörper (69) und Tropomyosin-2 Kits (6) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
TPM2 7169 P07951
TPM2 22004 P58774
TPM2 500450 P58775
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Showing 10 out of 22 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$4,331.68
Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$4,331.68
Details
Escherichia coli (E. coli) Human His tag 10 μg Anmelden zum Anzeigen 15 bis 19 Tage
$319.00
Details
Hefe Kaninchen His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,746.33
Details
Escherichia coli (E. coli) Human His tag Tropomyosin-2 (TPM2) (AA 14-284), (partial) protein (His tag) 50 μg Anmelden zum Anzeigen 13 bis 16 Tage
$242.00
Details
Escherichia coli (E. coli) Human His tag   50 μg Anmelden zum Anzeigen 11 Days
$341.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 10 bis 12 Tage
$785.40
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$405.71
Details
Hefe Yeast His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,365.00
Details
Hefe Hydrozoa His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,643.67
Details

TPM2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, , ,
Mouse (Murine)

Rat (Rattus)

Weitere Proteine zu Tropomyosin-2 (TPM2) Interaktionspartnern

Fruit Fly (Drosophila melanogaster) Tropomyosin-2 (TPM2) Interaktionspartner

  1. Tropomyosin2 dictates fundamental steps of myogenesis prior to regulating contraction in the sarcomere.

Human Tropomyosin-2 (TPM2) Interaktionspartner

  1. Stress fibre formation and up-regulation of alpha-smooth muscle actin (zeige ACTG2 Proteine) (alphaSMA (zeige ACTA2 Proteine)) induced by TGFbeta2 could be reversed by Tpm1 (zeige TPM1 Proteine)/2 knock-down by siRNA.

  2. Promoter variants in HOXA9 (zeige HOXA9 Proteine), TPM1 (zeige TPM1 Proteine), and TPM2, alter promoter expression suggesting that they have a functional role in clubfoot.

  3. TPM2 appears to be commonly silenced by aberrant DNA methylation (zeige HELLS Proteine) in colon cancer. TPM2 loss is associated with RhoA (zeige RHOA Proteine) activation and tumor proliferation.

  4. Despite its reduced affinity for actin in co-sedimentation assay, the Q147P mutant incorporates into the muscle fiber ..Q147P tropomyosin (TPM2)binds to actin in ghost muscle fiber.

  5. tropomyosin 2.1 acts as a suppressor of growth on soft matrices by supporting proper rigidity sensing

  6. Myo1c (zeige MYO1C Proteine) significantly increases the frequency of kinesin-1-driven microtubule-based runs that begin at actin/microtubule intersections. The actin-binding protein (zeige KPTN Proteine) tropomyosin 2 abolishes Myo1c (zeige MYO1C Proteine)-specific effects on both run initiation and run termination.

  7. Changes for CRMP2 (zeige DPYSL2 Proteine), TCP1epsilon, TPM2 and 14-3-3gamma (zeige YWHAG Proteine) were confirmed in experimental tumors and in a series of 28 human SI-NETs.

  8. Patients with TPM2 mutations tended to present with milder symptoms than those with TPM3 (zeige TPM3 Proteine) mutations, DA being present only in the TPM2 group.

  9. in a cohort of 94 patients with congenital myopathy, 2 related female patients and 2 sporadic male patients were found to carry mutations in TPM2 and TPM3 (zeige TPM3 Proteine) genes respectively; clinical presentation and muscle morphological findings differed in the patients

  10. Histopathological phenotype association of muscle fibers expressing Beta-tropomyosin mutational variants that occur in human myopathies.

Mouse (Murine) Tropomyosin-2 (TPM2) Interaktionspartner

  1. Stress fibre formation and up-regulation of alpha-smooth muscle actin (zeige ACTG2 Proteine) (alphaSMA (zeige ACTA2 Proteine)) induced by TGFbeta2 could be reversed by Tpm1 (zeige TPM1 Proteine)/2 knock-down by siRNA.

  2. Trop2 (zeige TACSTD2 Proteine) marks fetal glandular epithelial cells of the stomach, growing as spheroids when cultured ex vivo. In adults, upon injury, Trop2 (zeige TACSTD2 Proteine) expression is reactivated in regenerative cells together with part of a fetal-like genetic program.

  3. Trop-2 (zeige TACSTD2 Proteine) promotes an alpha5beta1 integrin-dependent pro-metastatic signaling pathway in PCa (zeige ENPP1 Proteine) cells and that the altered expression of Trop-2 (zeige TACSTD2 Proteine) may be utilized for early identification of capsule-invading PCa (zeige ENPP1 Proteine).

  4. our findings help to establish a close functional link between Trop2 (zeige TACSTD2 Proteine) and MSCs, and to provide a tool for future investigation of Trop2 (zeige TACSTD2 Proteine) in other types of stem cells

  5. data suggest that Trop2 (zeige TACSTD2 Proteine) regulates cell proliferation and motility and that it does so by regulating the ERK (zeige EPHB2 Proteine) pathway and several critical components of the cell migration apparatus

  6. Trop2 plays a cardioprotective role by promoting cardiac c-kit+ cell proliferation and inhibition of apoptosis in the acute phase of myocardial infarction.

  7. Generated chimeric alpha-/beta-tropomyosin protein to alter pathological consequences in mouse model of familial hypertrophic cardiomyopathy.

  8. Tm-2 (zeige TPM1 Proteine) is up-regulated during osteoclastogenesis, indicating potential cell-specific functions.

  9. Differential expression of RhoGDI-1, cofilin 1 and tropomyosin 2 in calpain-deficient fibroblasts compared with wild-type fibroblasts

Tropomyosin-2 (TPM2) Protein Überblick

Protein Überblick

This gene encodes beta-tropomyosin, a member of the actin filament binding protein family, and mainly expressed in slow, type 1 muscle fibers. Mutations in this gene can alter the expression of other sarcomeric tropomyosin proteins, and cause cap disease, nemaline myopathy and distal arthrogryposis syndromes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit Tropomyosin-2 Proteine (TPM2)

  • Tropomyosin 2 (Tm2)
  • Tropomyosin-2 (EDI_309330)
  • tropomyosin (LOC100101174)
  • tropomyosin 2 (beta) (tpm2)
  • tropomyosin 2 L homeolog (tpm2.L)
  • tropomyosin 2 (beta) (TPM2)
  • tropomyosin 2 (TPM2)
  • tropomyosin 2, beta (Tpm2)
  • tropomyosin 2 (Tpm2)
  • AMCD1 Protein
  • BRT-2 Protein
  • cb836 Protein
  • CG4843 Protein
  • DA1 Protein
  • DA2B Protein
  • Dmel\\CG4843 Protein
  • dro Tm Protein
  • DROTROPI1 Protein
  • fb68h02 Protein
  • Ifm(3)3 Protein
  • Ifm(3)5 Protein
  • Ifm-TmI Protein
  • l(3)nc99Eb Protein
  • mTmI Protein
  • NEM4 Protein
  • Tm Protein
  • Tm1 Protein
  • TM2 Protein
  • Tm127 Protein
  • TmI Protein
  • TmII Protein
  • TMSB Protein
  • Tn-H Protein
  • Tpm-2 Protein
  • tpm2 Protein
  • tpm2a Protein
  • TPM3 Protein
  • tpm4l Protein
  • Trop-2 Protein
  • wu:fb68h02 Protein
  • wu:fj63f03 Protein
  • zgc:86810 Protein

Bezeichner auf Proteinebene für Tropomyosin-2 Proteine (TPM2)

CG4843-PA , CG4843-PB , CG4843-PC , CG4843-PE , CG4843-PF , Tm2-PA , Tm2-PB , Tm2-PC , Tm2-PE , Tm2-PF , Tropomyosin-2 , lethal(3)nc99Eb , tropomyosin , tropomyosin 127 , tropomyosin 2 , tropomyosin I , tropomyosin2 , actotropomyosin , tropomyosin-2 , fj63f03 , tropomyosin beta chain , fast skeletal muscle beta-tropomyosin 2 , tropomyosin 2 a , tropomyosin 2 a (beta) , beta tropomyosin , beta-tropomyosin , tropomyosin 3 , nemaline myopathy type 4

GENE ID SPEZIES
41853 Drosophila melanogaster
5883196 Entamoeba dispar SAW760
100101174 Bombyx mori
415209 Danio rerio
100335131 Xenopus laevis
396430 Gallus gallus
7169 Homo sapiens
481598 Canis lupus familiaris
497015 Bos taurus
22004 Mus musculus
500450 Rattus norvegicus
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