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The protein encoded by TRIM24 mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. Zusätzlich bieten wir Ihnen TRIM24 Proteine (8) und TRIM24 Kits (2) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 118 products:
Human Polyclonal TRIM24 Primary Antibody für IP, WB - ABIN251037
Levin, Panchabhai, Shen, Kornblau, Qiu, Baggerly: Different changes in protein and phosphoprotein levels result from serum starvation of high-grade glioma and adenocarcinoma cell lines. in Journal of proteome research 2010
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Human Polyclonal TRIM24 Primary Antibody für ICC, IF - ABIN251036
Allton, Jain, Herz, Tsai, Jung, Qin, Bergmann, Johnson, Barton: Trim24 targets endogenous p53 for degradation. in Proceedings of the National Academy of Sciences of the United States of America 2009
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Human Monoclonal TRIM24 Primary Antibody für IF, IHC (p) - ABIN563797
Kikuchi, Okumura, Tsukiyama, Watanabe, Miyajima, Tanaka, Imamura, Hatakeyama: TRIM24 mediates ligand-dependent activation of androgen receptor and is repressed by a bromodomain-containing protein, BRD7, in prostate cancer cells. in Biochimica et biophysica acta 2009
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Human Polyclonal TRIM24 Primary Antibody für ICC, IF - ABIN4359700
Theurillat, Udeshi, Errington, Svinkina, Baca, Pop, Wild, Blattner, Groner, Rubin, Moch, Privé, Carr, Garraway: Prostate cancer. Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer. in Science (New York, N.Y.) 2014
Human Polyclonal TRIM24 Primary Antibody für IHC (p), IHC - ABIN268590
Thénot, Henriquet, Rochefort, Cavaillès: Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1. in The Journal of biological chemistry 1997
This study concluded that reduced TRIM24 protein is associated with poor survival in esophageal squamous cell cancer (ESCC) patients, suggesting TRIM24 protein is a potential prognostic biomarker for ESCC.
Data suggest that, in cardiomyocytes, TRIM32 attenuates activation of SRF signaling and hypertrophy due to dysbindin; TRIM24 promotes these effects. TRIM32 promotes dysbindin degradation; TRIM24 protects dysbindin from degradation. (TRIM = tripartite motif-containing protein; SRF = serum response factor)
hypothesis of "synergistic modification induced recognition" is then proposed to link histone modification and TRIM24 binding
Report provides evidence for an oncogenic role for TRIM24 as a transcriptional activator and mediator of hormone-refractory prostate cancer cell growth in SPOP (zeige SPOP Antikörper) mutant and castration-resistant prostate cells.
TRIM24 expression is positively correlated with Acetylated H3 lysine 23 levels, and high levels of both TRIM24 and Acetylated H3 lysine 23 predict shorter overall survival of breast cancer patients.
TRIM24 regulate resistance to Gefitinib via Akt (zeige AKT1 Antikörper) pathway in non-small cell lung cancer cells.
TRIM24 is overexpressed in human bladder cancer and facilitates bladder cancer growth and invasion, possibly through NF-kappaB (zeige NFKB1 Antikörper) and AKT (zeige AKT1 Antikörper) signaling pathways.
functions as an oncogene (zeige RAB1A Antikörper) in colorectal carcinogenesis
A role for TRIM24 in breast tumorigenesis through reprogramming of glucose metabolism in human mammary epithelial cells, further supporting TRIM24 as a viable therapeutic target in breast cancer.
our study shows that TRIM24 is overexpressed in human gastric cancer and accelerates cell growth as well as induce chemoresistance
Maintenance of pluripotency is regulated by a network of transcription factors coordinated by Oct4 (zeige POU5F1 Antikörper), Sox2 (zeige SOX2 Antikörper), and Nanog (zeige NANOG Antikörper); Trim24 significantly improved efficiency of cellular reprogramming, demonstrating its direct functionality in establishing pluripotency.
data identify a previously unappreciated Trim24-dependent requirement for IL-1R expression on TH2 cells and an important nonredundant role for T-cell-intrinsic Trim24 in TH2-mediated allergy and antihelminth immunity
Trim24 repressed VL30-class endogenous retroviruses retrotransposons
These results identify Trim24 as a novel negative regulator of the IFN/STAT (zeige STAT1 Antikörper) pathway and suggest that this repression through Rara (zeige RARA Antikörper) inhibition may prevent liver cancer.
Somatic hepatocyte-specific inactivation of TRIM24, TRIM28 (zeige TRIM28 Antikörper), or TRIM33 (zeige TRIM33 Antikörper) all promote hepatocellular carcinoma in a cell-autonomous manner in mice.
TRIM24 regulates AR-mediated transcription in collaboration with TIP60 (zeige KAT5 Antikörper) and BRD7 (zeige BRD7 Antikörper).
TIF1alpha-chromatin association is direct and involves DNA and nucleosome interactions mediated by the bromodomain
These studies indicate that TIF1alpha is a factor that modulates the expression of a set of genes during the first wave of genome activation in the mouse embryo.
The results not only provide genetic evidence that Trim24 and Rara (zeige RARA Antikörper) co-regulate hepatocarcinogenesis in an antagonistic manner but also suggest that aberrant activation of Rara (zeige RARA Antikörper) is deleterious to liver homeostasis.
TIF1alpha-null mutant pathological phenotype supports the hypothesis that aging is promoted by increased activity of the vitamin D signaling pathway
The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.
tripartite motif-containing 24
, transcriptional intermediary factor 1 alpha
, tripartite motif containing 24
, E3 ubiquitin-protein ligase TRIM24
, RING finger protein 82
, transcription intermediary factor 1-alpha
, transcriptional intermediary factor 1
, E3 ubiquitin-protein ligase Trim24
, transcriptional intermediary factor 1, alpha
, tripartite motif-containing protein 24